Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
phospho-p-S446,T599,S602,S729 BRAF [plasma membrane]
Stable Identifier
R-GGA-5672679
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
plasma membrane
Synonyms
Q04982
Locations in the PathwayBrowser
Expand all
Signal Transduction (Gallus gallus)
MAPK family signaling cascades (Gallus gallus)
MAPK1/MAPK3 signaling (Gallus gallus)
RAF/MAP kinase cascade (Gallus gallus)
MAP2K and MAPK activation (Gallus gallus)
Dissociation of RAS:RAF complex (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S446,T599,S602,S729 BRAF [plasma membrane] (Gallus gallus)
p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S446,T599,S602,S729 BRAF [plasma membrane] (Gallus gallus)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S446,T599,S602,S729 BRAF [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S446,T599,S602,S729 BRAF [plasma membrane] (Gallus gallus)
Dual mechanism MAPK inhibitors bind MAPKs (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S446,T599,S602,S729 BRAF [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S446,T599,S602,S729 BRAF [plasma membrane] (Gallus gallus)
MAP2Ks and MAPKs bind to the activated RAF complex (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S446,T599,S602,S729 BRAF [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S446,T599,S602,S729 BRAF [plasma membrane] (Gallus gallus)
MAP2Ks phosphorylate MAPKs (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S446,T599,S602,S729 BRAF [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S446,T599,S602,S729 BRAF [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S446,T599,S602,S729 BRAF [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S446,T599,S602,S729 BRAF [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S446,T599,S602,S729 BRAF [plasma membrane] (Gallus gallus)
RAF phosphorylates MAP2K dimer (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S446,T599,S602,S729 BRAF [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S446,T599,S602,S729 BRAF [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S446,T599,S602,S729 BRAF [plasma membrane] (Gallus gallus)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S446,T599,S602,S729 BRAF [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S446,T599,S602,S729 BRAF [plasma membrane] (Gallus gallus)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S446,T599,S602,S729 BRAF [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S446,T599,S602,S729 BRAF [plasma membrane] (Gallus gallus)
Negative regulation of MAPK pathway (Gallus gallus)
Negative feedback regulation of MAPK pathway (Gallus gallus)
Activated MAPKs phosphorylate BRAF (Gallus gallus)
phospho-p-S446,T599,S602,S729 BRAF [plasma membrane] (Gallus gallus)
RAF activation (Gallus gallus)
Phosphorylation of RAF (Gallus gallus)
RAF activating kinases [plasma membrane] (Gallus gallus)
phospho-p-S446,T599,S602,S729 BRAF [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S446,T599,S602,S729 BRAF [plasma membrane] (Gallus gallus)
External Reference Information
External Reference
UniProt:Q04982
Reference Genes
BioGPS Gene:396239
ENSEMBL:ENSGALG00000012865
KEGG Gene (Gallus gallus):396239
Monarch:396239
NCBI Gene:396239
Reference Transcript
RefSeq:XM_015284532.1
RefSeq:NM_205302.1
Participates
as an input of
Activated MAPKs phosphorylate BRAF (Gallus gallus)
as a candidate of
RAF activating kinases [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
Other forms of this molecule
BRAF [cytosol]
phospho-hyperphosphorylated BRAF [plasma membrane]
phospho-p-S365,S446,S729 BRAF [cytosol]
phospho-p-S446,S729-BRAF [cytosol]
phospho-p-S446,T599,S602,S729 BRAF [cytosol]
Inferred From
p-S446,T599,S602,S729 BRAF [plasma membrane]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 446 (in Homo sapiens)
Coordinate
446
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 729 (in Homo sapiens)
Coordinate
729
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 599 (in Homo sapiens)
Coordinate
599
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 602 (in Homo sapiens)
Coordinate
602
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_990633.1
,
XP_015140018.1
PRO
Q04982
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text