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phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]
Stable Identifier
R-GGA-5672665
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
plasma membrane
Synonyms
P05625
Locations in the PathwayBrowser
Expand all
Signal Transduction (Gallus gallus)
MAPK family signaling cascades (Gallus gallus)
MAPK1/MAPK3 signaling (Gallus gallus)
RAF/MAP kinase cascade (Gallus gallus)
MAP2K and MAPK activation (Gallus gallus)
Dissociation of RAS:RAF complex (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Gallus gallus)
p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Gallus gallus)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Gallus gallus)
Dual mechanism MAPK inhibitors bind MAPKs (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Gallus gallus)
MAP2Ks and MAPKs bind to the activated RAF complex (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Gallus gallus)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Gallus gallus)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Gallus gallus)
MAP2Ks phosphorylate MAPKs (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Gallus gallus)
RAF phosphorylates MAP2K dimer (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Gallus gallus)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Gallus gallus)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Gallus gallus)
Negative regulation of MAPK pathway (Gallus gallus)
Negative feedback regulation of MAPK pathway (Gallus gallus)
Activated MAPK phosphorylates RAF1 (Gallus gallus)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Gallus gallus)
PEBP1 binds activated RAF1 (Gallus gallus)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Gallus gallus)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Gallus gallus)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Gallus gallus)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Gallus gallus)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Gallus gallus)
RAF activation (Gallus gallus)
Phosphorylation of RAF (Gallus gallus)
RAF activating kinases [plasma membrane] (Gallus gallus)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Gallus gallus)
External Reference Information
External Reference
UniProt:P05625
Reference Genes
BioGPS Gene:396245
ENSEMBL:ENSGALG00000004998
ENSEMBL:ENSGALG00010027930.1
ENSEMBL:ENSGALG00015026065
KEGG Gene (Gallus gallus):396245
Monarch:396245
NCBI Gene:396245
Reference Transcript
RefSeq:XM_015293012.1
RefSeq:XM_015293009.1
RefSeq:NM_205307.2
RefSeq:XM_015293013.1
RefSeq:XM_015293010.1
RefSeq:XM_015293011.1
Other Identifiers
396245
GO:0000165
GO:0000166
GO:0003824
GO:0004672
GO:0004674
GO:0004709
GO:0005524
GO:0005737
GO:0005739
GO:0005829
GO:0005886
GO:0006468
GO:0007165
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0036211
GO:0043226
GO:0046872
GO:0106310
GO:0140096
GT_A_87_P131613
GT_A_87_P194458
Gga.685.1.S1_at
Gga.685.1.S2_at
Participates
as an input of
Activated MAPK phosphorylates RAF1 (Gallus gallus)
as a candidate of
RAF activating kinases [plasma membrane] (Gallus gallus)
as a component of
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Gallus gallus)
as a member of
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
Other forms of this molecule
phospho-p-S338,Y340,Y341-RAF1 [cytosol]
phospho-p-S338,Y341,T491,S494,S621 RAF1 [cytosol]
phospho-p-S621-RAF1 [cytosol]
phospho-p-Y-RAF1 [cytosol]
RAF1 [cytosol]
phospho-p-S259,S621-RAF1 [cytosol]
phospho-p-Y341,T491,S494,S621 RAF1 [plasma membrane]
phospho-p-S621-RAF1 [plasma membrane]
phospho-hyperphosphorylated RAF1 [plasma membrane]
phospho-p-S338-RAF1 [cytosol]
Inferred From
p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 621 (in Homo sapiens)
Coordinate
621
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O4'-phospho-L-tyrosine at 341 (in Homo sapiens)
Coordinate
341
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O-phospho-L-serine at 338 (in Homo sapiens)
Coordinate
338
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 491 (in Homo sapiens)
Coordinate
491
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 494 (in Homo sapiens)
Coordinate
494
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_015148496.1
,
XP_015148495.1
,
NP_990638.1
,
XP_015148498.1
,
XP_015148497.1
,
XP_015148499.1
IntEnz
2.7.11.1
Ensembl
ENSGALT00010067703
,
ENSGALG00010027930
,
ENSGALP00010041446
PRO
P05625
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