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ERCC8 [nucleoplasm]
Stable Identifier
R-GGA-52835
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
nucleoplasm
Synonyms
ERCC8, A0A8V0YGC8
Locations in the PathwayBrowser
Expand all
DNA Repair (Gallus gallus)
Nucleotide Excision Repair (Gallus gallus)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Gallus gallus)
Dual incision in TC-NER (Gallus gallus)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Gallus gallus)
TC-NER incision complex [nucleoplasm] (Gallus gallus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Gallus gallus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Gallus gallus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8 [nucleoplasm] (Gallus gallus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Gallus gallus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8 [nucleoplasm] (Gallus gallus)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Gallus gallus)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Gallus gallus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8 [nucleoplasm] (Gallus gallus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Gallus gallus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8 [nucleoplasm] (Gallus gallus)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Gallus gallus)
TC-NER pre-incision complex [nucleoplasm] (Gallus gallus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8 [nucleoplasm] (Gallus gallus)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Gallus gallus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8 [nucleoplasm] (Gallus gallus)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Gallus gallus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Gallus gallus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8 [nucleoplasm] (Gallus gallus)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Gallus gallus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8 [nucleoplasm] (Gallus gallus)
ERCC5 and RPA bind TC-NER site (Gallus gallus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Gallus gallus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Gallus gallus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8 [nucleoplasm] (Gallus gallus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Gallus gallus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8 [nucleoplasm] (Gallus gallus)
Formation of TC-NER Pre-Incision Complex (Gallus gallus)
Assembly of the pre-incision complex in TC-NER (Gallus gallus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8 [nucleoplasm] (Gallus gallus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Gallus gallus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8 [nucleoplasm] (Gallus gallus)
ERCC8 (CSA) binds stalled RNA Pol II (Gallus gallus)
ERCC8:DDB1:CUL4:RBX1:COP9 Signalosome [nucleoplasm] (Gallus gallus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8 [nucleoplasm] (Gallus gallus)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8 [nucleoplasm] (Gallus gallus)
ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Gallus gallus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8 [nucleoplasm] (Gallus gallus)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8 [nucleoplasm] (Gallus gallus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8 [nucleoplasm] (Gallus gallus)
UVSSA:USP7 deubiquitinates ERCC6 (Gallus gallus)
TC-NER pre-incision complex [nucleoplasm] (Gallus gallus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8 [nucleoplasm] (Gallus gallus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Gallus gallus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8 [nucleoplasm] (Gallus gallus)
Gap-filling DNA repair synthesis and ligation in TC-NER (Gallus gallus)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Gallus gallus)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Gallus gallus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8 [nucleoplasm] (Gallus gallus)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Gallus gallus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8 [nucleoplasm] (Gallus gallus)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Gallus gallus)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Gallus gallus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8 [nucleoplasm] (Gallus gallus)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Gallus gallus)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
ERCC8 [nucleoplasm] (Gallus gallus)
Metabolism of proteins (Gallus gallus)
Post-translational protein modification (Gallus gallus)
Neddylation (Gallus gallus)
CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Gallus gallus)
CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm] (Gallus gallus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Gallus gallus)
DCAF protein [nucleoplasm] (Gallus gallus)
ERCC8 [nucleoplasm] (Gallus gallus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Gallus gallus)
DCAF protein [nucleoplasm] (Gallus gallus)
ERCC8 [nucleoplasm] (Gallus gallus)
COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Gallus gallus)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Gallus gallus)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Gallus gallus)
DCAF protein [nucleoplasm] (Gallus gallus)
ERCC8 [nucleoplasm] (Gallus gallus)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Gallus gallus)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Gallus gallus)
DCAF protein [nucleoplasm] (Gallus gallus)
ERCC8 [nucleoplasm] (Gallus gallus)
External Reference Information
External Reference
UniProt:A0A8V0YGC8
Gene Names
ERCC8
Reference Genes
ENSEMBL:ENSGALG00010012669.1
UCSC:A0A8V0YGC8 ERCC8
Other Identifiers
427153
GO:0000012
GO:0000109
GO:0000209
GO:0005515
GO:0005634
GO:0005694
GO:0006281
GO:0006283
GO:0006974
GO:0006979
GO:0009411
GO:0009416
GO:0010165
GO:0016363
GO:0016567
GO:0030163
GO:0031464
GO:0032991
GO:0043161
GO:0051865
GO:0060090
GO:0080008
GO:0090262
GO:0090734
GO:0097680
GO:1990756
GT_A_87_P024073
Gga.11058.1.S1_at
Participates
as a member of
DCAF protein [nucleoplasm] (Gallus gallus)
as a component of
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Gallus gallus)
Inferred From
ERCC8 [nucleoplasm]
(Homo sapiens)
Cross References
ENSEMBL
ENSGALT00010030301
,
ENSGALG00010012669
,
ENSGALP00010017575
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