Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
APC [cytosol]
Stable Identifier
R-GGA-5246690
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
K63polyUb-APC, A0A1D5PC88
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Gallus gallus)
Post-translational protein modification (Gallus gallus)
Deubiquitination (Gallus gallus)
Ovarian tumor domain proteases (Gallus gallus)
ZRANB1 binds APC (Gallus gallus)
APC [cytosol] (Gallus gallus)
ZRANB1:K63polyUb-APC [cytosol] (Gallus gallus)
APC [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Signaling by WNT (Gallus gallus)
Degradation of beta-catenin by the destruction complex (Gallus gallus)
AXIN is phosphorylated in the destruction complex (Gallus gallus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Gallus gallus)
APC [cytosol] (Gallus gallus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Gallus gallus)
APC [cytosol] (Gallus gallus)
Association of beta-catenin with the destruction complex (Gallus gallus)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Gallus gallus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Gallus gallus)
APC [cytosol] (Gallus gallus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Gallus gallus)
APC [cytosol] (Gallus gallus)
Beta-catenin phosphorylation cascade (Gallus gallus)
Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Gallus gallus)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Gallus gallus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Gallus gallus)
APC [cytosol] (Gallus gallus)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Gallus gallus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Gallus gallus)
APC [cytosol] (Gallus gallus)
Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 (Gallus gallus)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Gallus gallus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Gallus gallus)
APC [cytosol] (Gallus gallus)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Gallus gallus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Gallus gallus)
APC [cytosol] (Gallus gallus)
Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Gallus gallus)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Gallus gallus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Gallus gallus)
APC [cytosol] (Gallus gallus)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Gallus gallus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Gallus gallus)
APC [cytosol] (Gallus gallus)
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Gallus gallus)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Gallus gallus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Gallus gallus)
APC [cytosol] (Gallus gallus)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Gallus gallus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Gallus gallus)
APC [cytosol] (Gallus gallus)
Phosphorylation of APC component of the destruction complex (Gallus gallus)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Gallus gallus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Gallus gallus)
APC [cytosol] (Gallus gallus)
ZRANB1 binds APC (Gallus gallus)
APC [cytosol] (Gallus gallus)
ZRANB1:K63polyUb-APC [cytosol] (Gallus gallus)
APC [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:A0A1D5PC88
Gene Names
APC
Reference Genes
ENSEMBL:ENSGALG00000000220
ENSEMBL:ENSGALG00010008333.1 APC
Reference Transcript
RefSeq:XM_004949281.2 APC
Other Identifiers
415607
GO:0000278
GO:0000281
GO:0000776
GO:0000910
GO:0001708
GO:0005515
GO:0005634
GO:0005694
GO:0005737
GO:0005794
GO:0005813
GO:0005815
GO:0005856
GO:0005874
GO:0005881
GO:0005886
GO:0005912
GO:0005923
GO:0006974
GO:0007010
GO:0007018
GO:0007026
GO:0007059
GO:0007094
GO:0007389
GO:0007399
GO:0008013
GO:0008017
GO:0008092
GO:0008285
GO:0008286
GO:0012501
GO:0016043
GO:0016055
GO:0016328
GO:0016342
GO:0016477
GO:0019887
GO:0019901
GO:0023052
GO:0030027
GO:0030154
GO:0030163
GO:0030178
GO:0030335
GO:0030877
GO:0031274
GO:0031625
GO:0032587
GO:0032886
GO:0043065
GO:0043226
GO:0043231
GO:0045295
GO:0045595
GO:0045732
GO:0048471
GO:0048856
GO:0048870
GO:0051010
GO:0051988
GO:0060632
GO:0065003
GO:0070840
GO:0071944
GO:0090090
GO:0098772
GO:0140014
GO:1902807
GO:1904781
GO:2000134
GT_A_87_P035507
GT_A_87_P092831
Gga.10382.1.S1_s_at
GgaAffx.137.1.S1_at
GgaAffx.25327.1.S1_at
Participates
as an input of
ZRANB1 binds APC (Gallus gallus)
as a component of
ZRANB1:K63polyUb-APC [cytosol] (Gallus gallus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Gallus gallus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Gallus gallus)
Other forms of this molecule
phospho-APC [cytosol]
APC [nucleoplasm]
APC [cytosol]
APC [cytosol]
APC [cytosol]
Inferred From
K63polyUb-APC [cytosol]
(Homo sapiens)
Modified Residues
Name
ubiquitinylated lysine (K63polyUb [cytosol]) at unknown position
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
XP_004949338.1
OpenTargets
ENSG00000134982
Ensembl
ENSGALT00010019940
,
ENSGALP00010011489
,
ENSGALG00010008333
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text