Reactome | JUN [nucleoplasm]

JUN [nucleoplasm]

Stable Identifier

R-GGA-450250

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

nucleoplasm

Synonyms

JUN, A0A8V1A1J7

Locations in the PathwayBrowser

Expand all

Immune System (Gallus gallus)

- Cytokine Signaling in Immune system (Gallus gallus)
  - Signaling by Interleukins (Gallus gallus)
    - Interleukin-17 signaling (Gallus gallus)
      - MAP kinase activation (Gallus gallus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
        
        Activation of the AP-1 family of transcription factors (Gallus gallus)
        
        Activated JNKs phosphorylate c-JUN (Gallus gallus)
        
        JUN [nucleoplasm] (Gallus gallus)
- Innate Immune System (Gallus gallus)
  - Fc epsilon receptor (FCERI) signaling (Gallus gallus)
    - FCERI mediated MAPK activation (Gallus gallus)
      - Activated JNKs phosphorylate c-JUN (Gallus gallus)
        
        JUN [nucleoplasm] (Gallus gallus)
  - Toll-like Receptor Cascades (Gallus gallus)
    - Toll Like Receptor 10 (TLR10) Cascade (Gallus gallus)
      - MyD88 cascade initiated on plasma membrane (Gallus gallus)
        
        MAP kinase activation (Gallus gallus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
        
        Activation of the AP-1 family of transcription factors (Gallus gallus)
        
        Activated JNKs phosphorylate c-JUN (Gallus gallus)
        
        JUN [nucleoplasm] (Gallus gallus)
    - Toll Like Receptor 2 (TLR2) Cascade (Gallus gallus)
      - Toll Like Receptor TLR1:TLR2 Cascade (Gallus gallus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
        
        MAP kinase activation (Gallus gallus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
        
        Activation of the AP-1 family of transcription factors (Gallus gallus)
        
        Activated JNKs phosphorylate c-JUN (Gallus gallus)
        
        JUN [nucleoplasm] (Gallus gallus)
      - Toll Like Receptor TLR6:TLR2 Cascade (Gallus gallus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
        
        MAP kinase activation (Gallus gallus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
        
        Activation of the AP-1 family of transcription factors (Gallus gallus)
        
        Activated JNKs phosphorylate c-JUN (Gallus gallus)
        
        JUN [nucleoplasm] (Gallus gallus)
    - Toll Like Receptor 3 (TLR3) Cascade (Gallus gallus)
      - MAP kinase activation (Gallus gallus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
        
        Activation of the AP-1 family of transcription factors (Gallus gallus)
        
        Activated JNKs phosphorylate c-JUN (Gallus gallus)
        
        JUN [nucleoplasm] (Gallus gallus)
    - Toll Like Receptor 4 (TLR4) Cascade (Gallus gallus)
      - MyD88-independent TLR4 cascade (Gallus gallus)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Gallus gallus)
        
        MAP kinase activation (Gallus gallus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
        
        Activation of the AP-1 family of transcription factors (Gallus gallus)
        
        Activated JNKs phosphorylate c-JUN (Gallus gallus)
        
        JUN [nucleoplasm] (Gallus gallus)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
        
        MAP kinase activation (Gallus gallus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
        
        Activation of the AP-1 family of transcription factors (Gallus gallus)
        
        Activated JNKs phosphorylate c-JUN (Gallus gallus)
        
        JUN [nucleoplasm] (Gallus gallus)
    - Toll Like Receptor 5 (TLR5) Cascade (Gallus gallus)
      - MyD88 cascade initiated on plasma membrane (Gallus gallus)
        
        MAP kinase activation (Gallus gallus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
        
        Activation of the AP-1 family of transcription factors (Gallus gallus)
        
        Activated JNKs phosphorylate c-JUN (Gallus gallus)
        
        JUN [nucleoplasm] (Gallus gallus)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Gallus gallus)
      - MyD88 dependent cascade initiated on endosome (Gallus gallus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Gallus gallus)
        
        MAP kinase activation (Gallus gallus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
        
        Activation of the AP-1 family of transcription factors (Gallus gallus)
        
        Activated JNKs phosphorylate c-JUN (Gallus gallus)
        
        JUN [nucleoplasm] (Gallus gallus)
    - Toll Like Receptor 9 (TLR9) Cascade (Gallus gallus)
      - MyD88 dependent cascade initiated on endosome (Gallus gallus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Gallus gallus)
        
        MAP kinase activation (Gallus gallus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
        
        Activation of the AP-1 family of transcription factors (Gallus gallus)
        
        Activated JNKs phosphorylate c-JUN (Gallus gallus)
        
        JUN [nucleoplasm] (Gallus gallus)

Signal Transduction (Gallus gallus)

- Signaling by Nuclear Receptors (Gallus gallus)
  - ESR-mediated signaling (Gallus gallus)
    - Estrogen-dependent gene expression (Gallus gallus)
      - Binding of AP1 transcriptional activator complexes to CCND1 promoter (Gallus gallus)
        
        CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3:ESTG:ESR1 dimer:JUN:ATF2:POUF21:ESTG:ESR1 dimer:JUN:FOS [nucleoplasm] (Gallus gallus)
        
        ESTG:ESR1 dimer:JUN:FOS [nucleoplasm] (Gallus gallus)
        
        FOS:JUN [nucleoplasm] (Gallus gallus)
        
        JUN [nucleoplasm] (Gallus gallus)
        
        ESTG:ESR1 dimer:JUN:FOS [nucleoplasm] (Gallus gallus)
        
        FOS:JUN [nucleoplasm] (Gallus gallus)
        
        JUN [nucleoplasm] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A8V1A1J7

Gene Names

JUN

Reference Genes

BioGPS Gene:424673 JUN

ENSEMBL:ENSGALG00010026886.1

KEGG:gga:424673 JUN

Monarch:424673 JUN

NCBI Gene:424673 JUN

UCSC:A0A8V1A1J7 JUN

Reference Transcript

RefSeq:NM_001031289.2 JUN

Other Identifiers

424673

GO:0000122

GO:0000785

GO:0000791

GO:0000976

GO:0000978

GO:0000981

GO:0001227

GO:0001228

GO:0001525

GO:0001774

GO:0001889

GO:0001938

GO:0002376

GO:0003151

GO:0003677

GO:0003682

GO:0003700

GO:0005096

GO:0005634

GO:0005654

GO:0005667

GO:0006355

GO:0006357

GO:0006915

GO:0007179

GO:0007254

GO:0008283

GO:0008285

GO:0009410

GO:0010634

GO:0017053

GO:0019046

GO:0019899

GO:0030154

GO:0030224

GO:0031103

GO:0031625

GO:0034976

GO:0035026

GO:0035497

GO:0035976

GO:0035994

GO:0042127

GO:0042802

GO:0043065

GO:0043066

GO:0043524

GO:0043922

GO:0043923

GO:0044389

GO:0045892

GO:0045893

GO:0045944

GO:0048146

GO:0048545

GO:0048856

GO:0051726

GO:0060395

GO:0061029

GO:0061629

GO:0070374

GO:0070412

GO:0071277

GO:0072740

GO:0090575

GO:0098772

GO:0140296

GO:1902895

GO:1904707

GO:1990837

GO:2000144

GT_A_87_P009238

GT_A_87_P054341

GT_Sp_Chicken_CN220440_2474

Gga.1473.1.S1_at

Participates

as an input of

Activated JNKs phosphorylate c-JUN (Gallus gallus)

as a component of

FOS:JUN [nucleoplasm] (Gallus gallus)

Other forms of this molecule

phospho-JUN [nucleoplasm]

Inferred From

JUN [nucleoplasm] (Homo sapiens)

Cross References

ENSEMBL

ENSGALT00010065247, ENSGALP00010039729, ENSGALG00010026886

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