Reactome | SH2D2A [cytosol]

SH2D2A [cytosol]

Stable Identifier

R-GGA-4420125

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

SH2D2A, A0A8V1A3U3

Locations in the PathwayBrowser

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Signal Transduction (Gallus gallus)

- Signaling by Receptor Tyrosine Kinases (Gallus gallus)
  - Signaling by VEGF (Gallus gallus)
    - VEGFA-VEGFR2 Pathway (Gallus gallus)
      - AXL autophosphorylates on Y779 and Y821 (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:AXL [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Gallus gallus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Gallus gallus)
        
        SH2D2A [cytosol] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Gallus gallus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Gallus gallus)
        
        SH2D2A [cytosol] (Gallus gallus)
      - Phosphorylation of SRC-1 (Gallus gallus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1 [plasma membrane] (Gallus gallus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Gallus gallus)
        
        SH2D2A [cytosol] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Gallus gallus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Gallus gallus)
        
        SH2D2A [cytosol] (Gallus gallus)
      - SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Gallus gallus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Gallus gallus)
        
        SH2D2A [cytosol] (Gallus gallus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1 [plasma membrane] (Gallus gallus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Gallus gallus)
        
        SH2D2A [cytosol] (Gallus gallus)
      - VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K/VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Gallus gallus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Gallus gallus)
        
        SH2D2A [cytosol] (Gallus gallus)
      - p-6Y-VEGFR2 binds SH2D2A (Gallus gallus)
        
        SH2D2A [cytosol] (Gallus gallus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Gallus gallus)
        
        SH2D2A [cytosol] (Gallus gallus)
      - p-AXL binds PI3K (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Gallus gallus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Gallus gallus)
        
        SH2D2A [cytosol] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Gallus gallus)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Gallus gallus)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Gallus gallus)
        
        SH2D2A [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A8V1A3U3

Gene Names

SH2D2A

Reference Genes

BioGPS Gene:425978 SH2D2A

ENSEMBL:ENSGALG00010027341.1

KEGG:gga:425978 SH2D2A

Monarch:425978 SH2D2A

NCBI Gene:425978 SH2D2A

UCSC:A0A8V1A3U3 SH2D2A

Reference Transcript

RefSeq:XM_015298430.4 SH2D2A

Other Identifiers

425978

GO:0005737

GT_Sp_ENSGALT00000029995_1141

GT_Sp_ENSGALT00000029995_1142

Gga.3320.1.A1_at

GgaAffx.8430.1.S1_at

Participates

as an input of

p-6Y-VEGFR2 binds SH2D2A (Gallus gallus)

as a component of

VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Gallus gallus)

Inferred From

SH2D2A [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_015153916.2

ENSEMBL

ENSGALT00010066289, ENSGALG00010027341, ENSGALP00010040555