Phosphorylation of MKK3/MKK6 by activated TAK1

Stable Identifier
R-GGA-437984
Type
Reaction [transition]
Species
Gallus gallus
Compartment
ReviewStatus
5/5
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MKK3 and MKK6 are two closely related dual-specificity protein kinases that activate p38 MAP kinase. MKK3 and MKK6 both phosphorylate and activate p38 MAP kinase at its activation site Thr-Gly-Tyr but do not phosphorylate or activate Erk1/2 or SAPK/JNK. MKK3 and MKK6 are both activated by different forms of cellular stress and inflammatory cytokines. Activation of MKK3 and MKK6 occurs through phosphorylation of serine and threonine residues at the typical Ser-Xaa-Ala-Xaa-Thr motif in their activation loop. Residues involved in activation of these protein kinases correspond to human sites Ser189 and Thr193 for MKK3 and Ser207 and Thr211 for MKK6.

Since there is no data for chicken MKK6, this hypothetical chicken protein is annotated in the chicken p38 pathway as homolog of well characterized human MKK6.

Literature References
PubMed ID Title Journal Year
15837794 Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes

Kracht, M, Wolter, S, Resch, K, Dittrich-Breiholz, O, Wirth, D, Thiefes, A, Mushinski, JF, Luckow, B, Schneider, H, Graue, N, Dörrie, A, Hoffmann, E

J Biol Chem 2005
8533096 Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction

Nishida, E, Shibuya, H, Shirakabe, K, Ueno, N, Oishi, I, Matsumoto, K, Yamaguchi, K, Irie, K, Taniguchi, T

Science 1995
16186825 Essential function for the kinase TAK1 in innate and adaptive immune responses

Kawai, T, Takeuchi, O, Sanjo, H, Takeda, K, Ninomiya-Tsuji, J, Sato, S, Yamamoto, M, Akira, S, Matsumoto, K

Nat Immunol 2005
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of Activated chicken TAK1 complexes [cytosol]

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