LPS binding to Toll like receptor 4 results in dimerization of the TLR4 associated with LY96

Stable Identifier
R-GGA-434058
Type
Reaction [binding]
Species
Gallus gallus
Compartment
plasma membrane
ReviewStatus
5/5
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LPS binding to Toll like receptor 4 results in dimerization of the TLR4 associated with LY96
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In mammals, LPS stimulation results in the formation of TLR4:LY96 complex (Park et al. 2009). Chicken TLR4:LY96 complex was also shown to mediate responsiveness to LPS (Keestra et al 2008). However, the authors suggested that differences in amino acid composition may results in the species-specific interaction between chTLR4 and chLY96.
Literature References
PubMed ID Title Journal Year
19627256 Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins

Carpenter, S, O'Neill, LA

Biochem J 2009
18768894 Unique properties of the chicken TLR4/MD-2 complex: selective lipopolysaccharide activation of the MyD88-dependent pathway

Keestra, AM, van Putten, JP

J Immunol 2008
15373971 Ligand-dependent Toll-like receptor 4 (TLR4)-oligomerization is directly linked with TLR4-signaling

Saitoh, S, Akashi, S, Yamada, T, Tanimura, N, Matsumoto, F, Fukase, K, Kusumoto, S, Kosugi, A, Miyake, K

J Endotoxin Res 2004
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Authored
Shamovsky, V  (2010-05-18)
Reviewed
D'Eustachio, P  (2010-10-16)
Created
Shamovsky, V  (2009-08-27)
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