Reactome | H3-VII [nucleoplasm]

H3-VII [nucleoplasm]

Stable Identifier

R-GGA-427407

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

nucleoplasm

Synonyms

Me2K10-HIST2H3A, P84229

Locations in the PathwayBrowser

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Gene expression (Transcription) (Gallus gallus)

- Epigenetic regulation of gene expression (Gallus gallus)
  - Negative epigenetic regulation of rRNA expression (Gallus gallus)
    - NoRC negatively regulates rRNA expression (Gallus gallus)
      - MBD2 binds methylcytosine in chromatin (Gallus gallus)
        
        Chromatin (H3K9me2, 5mC):MBD2 [nucleoplasm] (Gallus gallus)
        
        Chromatin with H3K9me2, 5mC [nucleoplasm] (Gallus gallus)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Gallus gallus)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Gallus gallus)
        
        H3-VII [nucleoplasm] (Gallus gallus)
        
        Chromatin with H3K9me2, 5mC [nucleoplasm] (Gallus gallus)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Gallus gallus)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Gallus gallus)
        
        H3-VII [nucleoplasm] (Gallus gallus)
- RNA Polymerase I Transcription (Gallus gallus)
  - RNA Polymerase I Promoter Clearance (Gallus gallus)
    - RNA Polymerase I Promoter Escape (Gallus gallus)
      - Elongation of pre-rRNA transcript (Gallus gallus)
        
        Chromatin (H3K9me2):CBX3 [nucleoplasm] (Gallus gallus)
        
        Chromatin (H3K9me2) [nucleoplasm] (Gallus gallus)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Gallus gallus)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Gallus gallus)
        
        H3-VII [nucleoplasm] (Gallus gallus)
    - RNA Polymerase I Promoter Opening (Gallus gallus)
      - UBF-1 Binds rDNA Promoter (Gallus gallus)
        
        Chromatin (H3K9me2, 5mC):MBD2 [nucleoplasm] (Gallus gallus)
        
        Chromatin with H3K9me2, 5mC [nucleoplasm] (Gallus gallus)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Gallus gallus)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Gallus gallus)
        
        H3-VII [nucleoplasm] (Gallus gallus)

Signal Transduction (Gallus gallus)

- Signaling by Nuclear Receptors (Gallus gallus)
  - ESR-mediated signaling (Gallus gallus)
    - Estrogen-dependent gene expression (Gallus gallus)
      - KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Gallus gallus)
        
        MYC gene, BCL2 gene: H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG:KDM1A [nucleoplasm] (Gallus gallus)
        
        MYC gene, BLC2 gene:H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Gallus gallus)
        
        Nucleosome with H3K9me2 and HIST1H2AC: [nucleoplasm] (Gallus gallus)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Gallus gallus)
        
        H3-VII [nucleoplasm] (Gallus gallus)
      - KDM1A is recruited to MYC and BCL2 genes (Gallus gallus)
        
        MYC gene, BCL2 gene: H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG:KDM1A [nucleoplasm] (Gallus gallus)
        
        MYC gene, BLC2 gene:H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Gallus gallus)
        
        Nucleosome with H3K9me2 and HIST1H2AC: [nucleoplasm] (Gallus gallus)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Gallus gallus)
        
        H3-VII [nucleoplasm] (Gallus gallus)
        
        MYC gene, BLC2 gene:H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Gallus gallus)
        
        Nucleosome with H3K9me2 and HIST1H2AC: [nucleoplasm] (Gallus gallus)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Gallus gallus)
        
        H3-VII [nucleoplasm] (Gallus gallus)

External Reference Information

External Reference

UniProt:P84229

Gene Names

H3-VII

Reference Genes

ENSEMBL:ENSGALG00010012169

KEGG:gga:100857439 H3-VII

KEGG:gga:100858681 H3-VII

KEGG:gga:417953 H3-VII

KEGG:gga:768333 H3-VII

KEGG:gga:769809 H3-VII

KEGG:gga:769852 H3-VII

KEGG:gga:770022 H3-VII

UCSC:P84229 H3-VII

Other Identifiers

100857439

100858681

121106438

121110383

417953

768333

769852

770022

GO:0000786

GO:0003677

GO:0005198

GO:0005634

GO:0005694

GO:0030527

GO:0046982

GT_A_87_P004039

GT_A_87_P052531

GT_A_87_P052571

GT_A_87_P052609

GT_A_87_P086856

GT_A_87_P086861

GT_A_87_P106898

GT_A_87_P106904

GT_A_87_P106928

GT_A_87_P106998

Gga.5576.1.S1_a_at

Gga.6103.1.S1_at

Gga.6103.1.S1_x_at

GgaAffx.23665.1.S1_at

GgaAffx.23665.1.S1_x_at

GgaAffx.23666.1.A1_at

GgaAffx.23666.1.S1_at

Participates

as a member of

Histone H3 dimethylated at lysine-9 [nucleoplasm] (Gallus gallus)

Other forms of this molecule

H3-VII [nucleoplasm]

H3-VII [extracellular region]

H3-VII [nucleoplasm]

phospho-H3-VII [nucleoplasm]

H3-VII [nucleoplasm]

Inferred From

Me2K10-HIST2H3A [nucleoplasm] (Homo sapiens)

Modified Residues

Name

N6,N6-dimethyl-L-lysine at 10 (in Homo sapiens)

Coordinate

PsiMod Name

N6,N6-dimethyl-L-lysine [MOD:00084]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6,N6-dimethyl-L-lysine.

Cross References

ENSEMBL

ENSGALP00010017063, ENSGALT00010029191, ENSGALT00010032659, ENSGALP00010019354, ENSGALP00010017073, ENSGALT00010029395, ENSGALP00010017166, ENSGALP00010017077, ENSGALP00010016931, ENSGALT00010029400, ENSGALT00010029379, ENSGALG00010013592, ENSGALG00010012266, ENSGALG00010012277, ENSGALT00010029534, ENSGALG00010012169, ENSGALG00010012338

PRO

P84229

PDB

7BY0, 3C9K, 1TZY, 2HIO, 7BXT, 1HIO, 1HQ3, 2ARO, 1EQZ