Reactome | uroporphyrinogen III => coproporphyrinogen III + 4 CO2

uroporphyrinogen III => coproporphyrinogen III + 4 CO2

Stable Identifier

R-GGA-421515

Type

Reaction [transition]

Species

Gallus gallus

Compartment

cytosol

ReviewStatus

5/5

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uroporphyrinogen III => coproporphyrinogen III + 4 CO2

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Cytosolic UROD (uroporphyrinogen decarboxylase) catalyzes the reaction of uroporphyrinogen III to form coproporphyrinogen III and four molecules of CO2. Chicken UROD is known only as the inferred product of a gene discovered by analysis of the chicken genomic DNA sequence. Its dimerization to form an active enzyme and its catalytic activity are inferred from the properties of its better-studied human counterpart.

Literature References

PubMed ID	Title	Journal	Year
17360334	A porphomethene inhibitor of uroporphyrinogen decarboxylase causes porphyria cutanea tarda Phillips, JD, Bergonia, HA, Reilly, CA, Franklin, MR, Kushner, JP	Proc. Natl. Acad. Sci. U.S.A.	2007
	The Metabolic and Molecular Bases of Inherited Diseases Valle, D		2001