Reactome | GRIN2B [plasma membrane]

GRIN2B [plasma membrane]

Stable Identifier

R-GGA-419558

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

plasma membrane

Synonyms

F1NMB0

Locations in the PathwayBrowser

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Neuronal System (Gallus gallus)

- Protein-protein interactions at synapses (Gallus gallus)
  - Synaptic adhesion-like molecules (Gallus gallus)
    - SALM2 associate with AMPA and NMDA receptors (Gallus gallus)
      - AMPA, NMDA receptors [plasma membrane] (Gallus gallus)
        
        NMDA receptor complex [plasma membrane] (Gallus gallus)
        
        NMDA receptor [plasma membrane] (Gallus gallus)
        
        NR2 subunits [plasma membrane] (Gallus gallus)
        
        GRIN2B [plasma membrane] (Gallus gallus)
      - SALM2:AMPA, NMDA receptors [plasma membrane] (Gallus gallus)
        
        AMPA, NMDA receptors [plasma membrane] (Gallus gallus)
        
        NMDA receptor complex [plasma membrane] (Gallus gallus)
        
        NMDA receptor [plasma membrane] (Gallus gallus)
        
        NR2 subunits [plasma membrane] (Gallus gallus)
        
        GRIN2B [plasma membrane] (Gallus gallus)
- Transmission across Chemical Synapses (Gallus gallus)
  - Neurotransmitter receptors and postsynaptic signal transmission (Gallus gallus)
    - Activation of NMDA receptors and postsynaptic events (Gallus gallus)
      - Unblocking of NMDA receptors, glutamate binding and activation (Gallus gallus)
        
        Ca2+ influx into the post-synaptic cell (Gallus gallus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2 NMDA receptors [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B di-heterotetramer [plasma membrane] (Gallus gallus)
        
        GRIN2B [plasma membrane] (Gallus gallus)
        
        Membrane depolarization upon activation of Ca impermeable AMPA receptors (Gallus gallus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Gallus gallus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B di-heterotetramer [plasma membrane] (Gallus gallus)
        
        GRIN2B [plasma membrane] (Gallus gallus)

Signal Transduction (Gallus gallus)

- MAPK family signaling cascades (Gallus gallus)
  - MAPK1/MAPK3 signaling (Gallus gallus)
    - RAF/MAP kinase cascade (Gallus gallus)
      - RAS GEFs promote RAS nucleotide exchange (Gallus gallus)
        
        RAS GEFs [plasma membrane] (Gallus gallus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Gallus gallus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Gallus gallus)
        
        GRIN1:GRIN2B di-heterotetramer [plasma membrane] (Gallus gallus)
        
        GRIN2B [plasma membrane] (Gallus gallus)

External Reference Information

External Reference

UniProt:F1NMB0

Reference Genes

BioGPS Gene:417965

ENSEMBL:ENSGALG00010011090.1

Monarch:417965

NCBI Gene:417965

UCSC:F1NMB0

Reference Transcript

Other Identifiers

417965

GO:0004972

GO:0005216

GO:0005886

GO:0006811

GO:0015276

GO:0016020

GO:0016594

GO:0017146

GO:0022849

GO:0038023

GO:0045471

GO:0055085

GO:0097553

GO:0098655

GO:0099507

GT_A_87_P107108

GT_A_87_P265163

GgaAffx.7496.1.S1_at

Participates

as a member of

NR2 subunits [plasma membrane] (Gallus gallus)

as a component of

GRIN1:GRIN2B di-heterotetramer [plasma membrane] (Gallus gallus)

Other forms of this molecule

phospho-p-Y1252,Y1336,Y1474-GRIN2B [plasma membrane]

GRIN2B [endoplasmic reticulum membrane]

Inferred From

GRIN2B [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_040524352.1, XP_040516439.1, XP_046770889.1, XP_046764771.1

ENSEMBL

ENSGALP00010015120, ENSGALG00010011090, ENSGALT00010026543

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