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CUL2 [cytosol]
Stable Identifier
R-GGA-416982
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
CUL2, A0A8V0XHD8
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Gallus gallus)
Cellular responses to stress (Gallus gallus)
Cellular response to hypoxia (Gallus gallus)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Gallus gallus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Gallus gallus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
CUL2 [cytosol] (Gallus gallus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Gallus gallus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
CUL2 [cytosol] (Gallus gallus)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Gallus gallus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Gallus gallus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
CUL2 [cytosol] (Gallus gallus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Gallus gallus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
CUL2 [cytosol] (Gallus gallus)
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Gallus gallus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
CUL2 [cytosol] (Gallus gallus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Gallus gallus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
CUL2 [cytosol] (Gallus gallus)
Proteasome proteolyzes ub-HIF-alpha (Gallus gallus)
VBC complex (with or without LIMD1) [cytosol] (Gallus gallus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
CUL2 [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
CUL2 [cytosol] (Gallus gallus)
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Gallus gallus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
CUL2 [cytosol] (Gallus gallus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Gallus gallus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
CUL2 [cytosol] (Gallus gallus)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Gallus gallus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
CUL2 [cytosol] (Gallus gallus)
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
Class I MHC mediated antigen processing & presentation (Gallus gallus)
Antigen processing: Ubiquitination & Proteasome degradation (Gallus gallus)
Interaction of E3 with substrate and E2-Ub complex (Gallus gallus)
Ag-substrate:E3:E2:Ub [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
CUL2 [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
CUL2 [cytosol] (Gallus gallus)
Polyubiquitination of substrate (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
CUL2 [cytosol] (Gallus gallus)
E3:K48-polyubiquitinated substrate [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
CUL2 [cytosol] (Gallus gallus)
E3:Ub:substrate [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
CUL2 [cytosol] (Gallus gallus)
Release of E3 from polyubiquitinated substrate (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
CUL2 [cytosol] (Gallus gallus)
E3:K48-polyubiquitinated substrate [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
CUL2 [cytosol] (Gallus gallus)
Transfer of Ub from E2 to substrate and release of E2 (Gallus gallus)
Ag-substrate:E3:E2:Ub [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
CUL2 [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
CUL2 [cytosol] (Gallus gallus)
E3:Ub:substrate [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
CUL2 [cytosol] (Gallus gallus)
Metabolism of proteins (Gallus gallus)
Post-translational protein modification (Gallus gallus)
Neddylation (Gallus gallus)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Gallus gallus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Gallus gallus)
CRL E3 ubiquitin ligases [cytosol] (Gallus gallus)
CRL2 E3 ubiquitin ligase [cytosol] (Gallus gallus)
CUL2 [cytosol] (Gallus gallus)
CRL E3 ubiquitin ligases [cytosol] (Gallus gallus)
CRL2 E3 ubiquitin ligase [cytosol] (Gallus gallus)
CUL2 [cytosol] (Gallus gallus)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Gallus gallus)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Gallus gallus)
CRL2 E3 ubiquitin ligase [cytosol] (Gallus gallus)
CUL2 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:A0A8V0XHD8
Gene Names
CUL2
Reference Genes
ENSEMBL:ENSGALG00010004507.1
UCSC:A0A8V0XHD8 CUL2
Other Identifiers
420467
GO:0005634
GO:0005654
GO:0006511
GO:0030163
GO:0031461
GO:0031462
GO:0031625
GO:0031981
GO:0060090
GO:0140627
GO:0160072
GT_A_87_P035556
GT_A_87_P205783
GT_A_87_P232573
Gga.7042.1.S1_a_at
GgaAffx.4436.1.S1_at
Participates
as a component of
CRL2 E3 ubiquitin ligase [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
Other forms of this molecule
CUL2 [cytosol]
CUL2 [nucleoplasm]
Inferred From
CUL2 [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSGALG00010004507
,
ENSGALP00010006120
,
ENSGALT00010010515
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