Phosphorylation of ephexin1

Stable Identifier
R-GGA-3928596
Type
Reaction [transition]
Species
Gallus gallus
Compartment
General
SVG |   | PPTX  | SBGN
Phosphorylation of ephexin1

Activation of EPHAs leads to phosphorylation of ephexin1 (NGEF) on conserved tyrosine (Y) 179 (Y87 in isoform3) by Src family kinases (SFKs). This phosphorylation preferentially activates NGEF’s GDP/GTP exchange activity specifically towards RHOA but not RAC1 and CDC42, thus switching the substrate preference of NGEF and leading to actin cytoskeletal changes that result in growth cone collapse (Sahin et al. 2005, Knoll and Drescher 2004).

Literature References
PubMed ID Title Journal Year
15254079 Src family kinases are involved in EphA receptor-mediated retinal axon guidance

Knöll, B, Drescher, U

J. Neurosci. 2004
15848799 Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse

Sahin, M, Greer, PL, Lin, MZ, Poucher, H, Eberhart, J, Schmidt, S, Wright, TM, Shamah, SM, O'connell, S, Cowan, CW, Hu, L, Goldberg, JL, Debant, A, Corfas, G, Krull, CE, Greenberg, ME

Neuron 2005
Participants
Orthologous Events
Authored
Reviewed
Created