Reactome | CHRM2 [plasma membrane]

CHRM2 [plasma membrane]

Stable Identifier

R-GGA-390654

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

plasma membrane

Synonyms

CHRM2, P30372

Locations in the PathwayBrowser

Expand all

Signal Transduction (Gallus gallus)

- Signaling by GPCR (Gallus gallus)
  - GPCR downstream signalling (Gallus gallus)
    - G alpha (i) signalling events (Gallus gallus)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Gallus gallus)
        
        CHRM2,CHRM4 [plasma membrane] (Gallus gallus)
        
        CHRM2 [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Gallus gallus)
        
        CHRM2,CHRM4 [plasma membrane] (Gallus gallus)
        
        CHRM2 [plasma membrane] (Gallus gallus)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Gallus gallus)
        
        CHRM2,CHRM4 [plasma membrane] (Gallus gallus)
        
        CHRM2 [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Gallus gallus)
        
        CHRM2,CHRM4 [plasma membrane] (Gallus gallus)
        
        CHRM2 [plasma membrane] (Gallus gallus)
      - The Ligand:GPCR:Gi complex dissociates (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Gallus gallus)
        
        CHRM2,CHRM4 [plasma membrane] (Gallus gallus)
        
        CHRM2 [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Gallus gallus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Gallus gallus)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Gallus gallus)
        
        CHRM2,CHRM4 [plasma membrane] (Gallus gallus)
        
        CHRM2 [plasma membrane] (Gallus gallus)
  - GPCR ligand binding (Gallus gallus)
    - Class A/1 (Rhodopsin-like receptors) (Gallus gallus)
      - Amine ligand-binding receptors (Gallus gallus)
        
        Muscarinic acetylcholine receptors (Gallus gallus)
        
        CHRM2 binds CHRM2 antagonists (Gallus gallus)
        
        CHRM2 [plasma membrane] (Gallus gallus)
        
        CHRM2:CHRM2 antagonists [plasma membrane] (Gallus gallus)
        
        CHRM2 [plasma membrane] (Gallus gallus)
        
        CHRM2,4 bind acetylcholine (Gallus gallus)
        
        CHRM2,CHRM4 [plasma membrane] (Gallus gallus)
        
        CHRM2 [plasma membrane] (Gallus gallus)
        
        CHRM2,CHRM4:AcCho [plasma membrane] (Gallus gallus)
        
        CHRM2,CHRM4 [plasma membrane] (Gallus gallus)
        
        CHRM2 [plasma membrane] (Gallus gallus)

External Reference Information

External Reference

UniProt:P30372

Gene Names

CHRM2

Reference Genes

BioGPS Gene:418126 CHRM2

ENSEMBL:ENSGALG00000012894

ENSEMBL:ENSGALG00000055458 CHRM2

ENSEMBL:ENSGALG00010013994.1 CHRM2

KEGG Gene (Gallus gallus):418126 CHRM2

Monarch:418126 CHRM2

NCBI Gene:418126 CHRM2

Reference Transcript

Other Identifiers

418126

GO:0003012

GO:0003013

GO:0004930

GO:0004993

GO:0005886

GO:0006940

GO:0007165

GO:0007186

GO:0007187

GO:0007197

GO:0007213

GO:0007268

GO:0008016

GO:0009615

GO:0016020

GO:0016907

GO:0023052

GO:0030425

GO:0045202

GO:0045211

GO:0060089

GO:0098664

GO:0098793

GO:0098981

GO:0099171

GO:1990763

GT_A_87_P022406

Gga.10240.1.S1_at

Participates

as an input of

CHRM2 binds CHRM2 antagonists (Gallus gallus)

as a component of

CHRM2:CHRM2 antagonists [plasma membrane] (Gallus gallus)

as a member of

CHRM2,CHRM4 [plasma membrane] (Gallus gallus)

Inferred From

CHRM2 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001025936.1, XP_015141117.1, XP_015141126.1, XP_015141131.1

OpenTargets

ENSG00000181072

Ensembl

ENSGALP00010019783, ENSGALT00010033570, ENSGALG00010013994, ENSGALP00010019773, ENSGALP00010019779, ENSGALT00010033599, ENSGALT00010033593, ENSGALP00010019786, ENSGALT00010033573, ENSGALT00010033550, ENSGALT00010033578, ENSGALT00010033586, ENSGALT00010033559, ENSGALP00010019775, ENSGALP00010019790, ENSGALP00010019778, ENSGALP00010019788, ENSGALP00010019781, ENSGALP00010019777, ENSGALT00010033565, ENSGALT00010033554

PRO

P30372