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phospho-MAP3K8 [cytosol]
Stable Identifier
R-GGA-389738
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
p-S400-MAP3K8, E1C848
Locations in the PathwayBrowser
Expand all
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
Regulation of T cell activation by CD28 family (Gallus gallus)
Co-stimulation by CD28 (Gallus gallus)
CD28 dependent PI3K/Akt signaling (Gallus gallus)
AKT interacts and phosphorylates Cot (Gallus gallus)
phospho-MAP3K8 [cytosol] (Gallus gallus)
p-S400-Cot phosphorylates NIK (Gallus gallus)
phospho-MAP3K8 [cytosol] (Gallus gallus)
Cytokine Signaling in Immune system (Gallus gallus)
Signaling by Interleukins (Gallus gallus)
Interleukin-1 family signaling (Gallus gallus)
Interleukin-1 signaling (Gallus gallus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Gallus gallus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Gallus gallus)
NFKB1:p-S400-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-MAP3K8 [cytosol] (Gallus gallus)
Interleukin-17 signaling (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Gallus gallus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Gallus gallus)
NFKB1:p-S400-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-MAP3K8 [cytosol] (Gallus gallus)
Innate Immune System (Gallus gallus)
Toll-like Receptor Cascades (Gallus gallus)
Toll Like Receptor 10 (TLR10) Cascade (Gallus gallus)
MyD88 cascade initiated on plasma membrane (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Gallus gallus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Gallus gallus)
NFKB1:p-S400-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-MAP3K8 [cytosol] (Gallus gallus)
Toll Like Receptor 2 (TLR2) Cascade (Gallus gallus)
Toll Like Receptor TLR1:TLR2 Cascade (Gallus gallus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Gallus gallus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Gallus gallus)
NFKB1:p-S400-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-MAP3K8 [cytosol] (Gallus gallus)
Toll Like Receptor TLR6:TLR2 Cascade (Gallus gallus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Gallus gallus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Gallus gallus)
NFKB1:p-S400-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-MAP3K8 [cytosol] (Gallus gallus)
Toll Like Receptor 3 (TLR3) Cascade (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Gallus gallus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Gallus gallus)
NFKB1:p-S400-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-MAP3K8 [cytosol] (Gallus gallus)
Toll Like Receptor 4 (TLR4) Cascade (Gallus gallus)
MyD88-independent TLR4 cascade (Gallus gallus)
TRIF (TICAM1)-mediated TLR4 signaling (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Gallus gallus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Gallus gallus)
NFKB1:p-S400-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-MAP3K8 [cytosol] (Gallus gallus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Gallus gallus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Gallus gallus)
NFKB1:p-S400-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-MAP3K8 [cytosol] (Gallus gallus)
Toll Like Receptor 5 (TLR5) Cascade (Gallus gallus)
MyD88 cascade initiated on plasma membrane (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Gallus gallus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Gallus gallus)
NFKB1:p-S400-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-MAP3K8 [cytosol] (Gallus gallus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Gallus gallus)
MyD88 dependent cascade initiated on endosome (Gallus gallus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Gallus gallus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Gallus gallus)
NFKB1:p-S400-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-MAP3K8 [cytosol] (Gallus gallus)
Toll Like Receptor 9 (TLR9) Cascade (Gallus gallus)
MyD88 dependent cascade initiated on endosome (Gallus gallus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Gallus gallus)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Gallus gallus)
NFKB1:p-S400-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-MAP3K8 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:E1C848
Gene Names
MAP3K8
Reference Genes
BioGPS Gene:420479 MAP3K8
ENSEMBL:ENSGALG00010004987.1
KEGG:gga:420479 MAP3K8
Monarch:420479 MAP3K8
NCBI Gene:420479 MAP3K8
UCSC:E1C848 MAP3K8
Reference Transcript
RefSeq:XM_040665361.2 MAP3K8
RefSeq:XM_015282086.4 MAP3K8
RefSeq:XM_040665363.2 MAP3K8
RefSeq:XM_418581.8 MAP3K8
RefSeq:XM_015282087.4 MAP3K8
Other Identifiers
420479
GO:0000165
GO:0000166
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004709
GO:0005524
GO:0005737
GO:0005829
GO:0006468
GO:0016301
GO:0016740
GO:0046872
GO:0050729
GO:0140096
GT_A_87_P101211
Gga.8861.1.S1_at
GgaAffx.4586.1.S1_at
Participates
as an output of
AKT interacts and phosphorylates Cot (Gallus gallus)
as a component of
NFKB1:p-S400-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
Other forms of this molecule
MAP3K8 [cytosol]
phospho-MAP3K8 [cytosol]
Inferred From
p-S400-MAP3K8 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 400 (in Homo sapiens)
Coordinate
400
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_040521295.1
,
XP_418581.3
,
XP_015137573.1
,
XP_015137572.1
,
XP_040521297.1
ENSEMBL
ENSGALG00010004987
,
ENSGALP00010006560
,
ENSGALT00010011710
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