Reactome | CBX8 [nucleoplasm]

CBX8 [nucleoplasm]

Stable Identifier

R-GGA-389117

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

nucleoplasm

Synonyms

CBX8, A0A8V1AIW2

Locations in the PathwayBrowser

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Gene expression (Transcription) (Gallus gallus)

- RNA Polymerase II Transcription (Gallus gallus)
  - Generic Transcription Pathway (Gallus gallus)
    - Transcriptional regulation by RUNX1 (Gallus gallus)
      - RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Gallus gallus)
        
        RUNX1 binds PRC1 complexes (Gallus gallus)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Gallus gallus)
        
        PRC1.4 [nucleoplasm] (Gallus gallus)
        
        CBX2,CBX4,CBX8 [nucleoplasm] (Gallus gallus)
        
        CBX8 [nucleoplasm] (Gallus gallus)
        
        RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Gallus gallus)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Gallus gallus)
        
        PRC1.4 [nucleoplasm] (Gallus gallus)
        
        CBX2,CBX4,CBX8 [nucleoplasm] (Gallus gallus)
        
        CBX8 [nucleoplasm] (Gallus gallus)

Signal Transduction (Gallus gallus)

- Intracellular signaling by second messengers (Gallus gallus)
  - PIP3 activates AKT signaling (Gallus gallus)
    - PTEN Regulation (Gallus gallus)
      - Regulation of PTEN gene transcription (Gallus gallus)
        
        MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Gallus gallus)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Gallus gallus)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Gallus gallus)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Gallus gallus)
        
        PRC1.4 [nucleoplasm] (Gallus gallus)
        
        CBX2,CBX4,CBX8 [nucleoplasm] (Gallus gallus)
        
        CBX8 [nucleoplasm] (Gallus gallus)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Gallus gallus)
        
        PRC1.4 [nucleoplasm] (Gallus gallus)
        
        CBX2,CBX4,CBX8 [nucleoplasm] (Gallus gallus)
        
        CBX8 [nucleoplasm] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A8V1AIW2

Gene Names

CBX8

Reference Genes

BioGPS Gene:422084 CBX8

ENSEMBL:ENSGALG00010029231.1

KEGG:gga:422084 CBX8

Monarch:422084 CBX8

NCBI Gene:422084 CBX8

UCSC:A0A8V1AIW2 CBX8

Reference Transcript

RefSeq:XM_015295594.4 CBX8

Other Identifiers

422084

GO:0000122

GO:0000785

GO:0000792

GO:0003682

GO:0003723

GO:0003727

GO:0005634

GO:0005654

GO:0006325

GO:0006355

GO:0031519

GO:0035102

GO:0042393

GO:0061628

GO:0097027

GO:0098772

GT_A_87_P067676

Gga.15502.1.A1_at

GgaAffx.22142.2.S1_s_at

GgaAffx.4422.1.S1_at

Participates

as a component of

as a member of

CBX2,CBX4,CBX8 [nucleoplasm] (Gallus gallus)

Inferred From

CBX8 [nucleoplasm] (Homo sapiens)

Cross References

ENSEMBL

ENSGALP00010043337, ENSGALG00010029231, ENSGALT00010070646