Reactome | ADCY2 [plasma membrane]

ADCY2 [plasma membrane]

Stable Identifier

R-GGA-379052

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

plasma membrane

Synonyms

E1BX91

Locations in the PathwayBrowser

Expand all

Neuronal System (Gallus gallus)

- Transmission across Chemical Synapses (Gallus gallus)
  - Neurotransmitter receptors and postsynaptic signal transmission (Gallus gallus)
    - GABA receptor activation (Gallus gallus)
      - GABA B receptor activation (Gallus gallus)
        
        Activation of GABAB receptors (Gallus gallus)
        
        Adenylate cyclase inhibitory pathway (Gallus gallus)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Gallus gallus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Gallus gallus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        ADCY2 [plasma membrane] (Gallus gallus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Gallus gallus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        ADCY2 [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Gallus gallus)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        ADCY2 [plasma membrane] (Gallus gallus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Gallus gallus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        ADCY2 [plasma membrane] (Gallus gallus)
        
        Dissociation of the Gi alpha:G olf complex (Gallus gallus)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        ADCY2 [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        ADCY2 [plasma membrane] (Gallus gallus)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Gallus gallus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Gallus gallus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        ADCY2 [plasma membrane] (Gallus gallus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        ADCY2 [plasma membrane] (Gallus gallus)

Signal Transduction (Gallus gallus)

- Intracellular signaling by second messengers (Gallus gallus)
  - DAG and IP3 signaling (Gallus gallus)
    - CaM pathway (Gallus gallus)
      - Calmodulin induced events (Gallus gallus)
        
        PKA-mediated phosphorylation of CREB (Gallus gallus)
        
        PKA activation (Gallus gallus)
        
        Adenylate cyclase produces cAMP (Gallus gallus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        ADCY2 [plasma membrane] (Gallus gallus)
- Signaling by GPCR (Gallus gallus)
  - GPCR downstream signalling (Gallus gallus)
    - G alpha (i) signalling events (Gallus gallus)
      - Opioid Signalling (Gallus gallus)
        
        G-protein mediated events (Gallus gallus)
        
        Adenylate cyclase activating pathway (Gallus gallus)
        
        Adenylate cyclase converts ATP into cyclic AMP (Gallus gallus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        ADCY2 [plasma membrane] (Gallus gallus)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        ADCY2 [plasma membrane] (Gallus gallus)
        
        Adenylaye cyclase increases the GTPase activity of G alpha-olf (Gallus gallus)
        
        G alpha-olf:GDP:Adenylate cyclase (active) complex [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        ADCY2 [plasma membrane] (Gallus gallus)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        ADCY2 [plasma membrane] (Gallus gallus)
        
        Galpha-olf:GTP binds to adenylate cyclase and activates it (Gallus gallus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        ADCY2 [plasma membrane] (Gallus gallus)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        ADCY2 [plasma membrane] (Gallus gallus)
        
        The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Gallus gallus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        ADCY2 [plasma membrane] (Gallus gallus)
        
        G alpha-olf:GDP:Adenylate cyclase (active) complex [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        ADCY2 [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase inhibitory pathway (Gallus gallus)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Gallus gallus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Gallus gallus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        ADCY2 [plasma membrane] (Gallus gallus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Gallus gallus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        ADCY2 [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Gallus gallus)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        ADCY2 [plasma membrane] (Gallus gallus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Gallus gallus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        ADCY2 [plasma membrane] (Gallus gallus)
        
        Dissociation of the Gi alpha:G olf complex (Gallus gallus)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        ADCY2 [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        ADCY2 [plasma membrane] (Gallus gallus)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Gallus gallus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Gallus gallus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        ADCY2 [plasma membrane] (Gallus gallus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        ADCY2 [plasma membrane] (Gallus gallus)
        
        PLC beta mediated events (Gallus gallus)
        
        Ca-dependent events (Gallus gallus)
        
        CaM pathway (Gallus gallus)
        
        Calmodulin induced events (Gallus gallus)
        
        PKA-mediated phosphorylation of CREB (Gallus gallus)
        
        PKA activation (Gallus gallus)
        
        Adenylate cyclase produces cAMP (Gallus gallus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        ADCY2 [plasma membrane] (Gallus gallus)
    - G alpha (z) signalling events (Gallus gallus)
      - G alpha (z) inhibits adenylate cyclase (Gallus gallus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        ADCY2 [plasma membrane] (Gallus gallus)
        
        G-protein alpha (z):GTP:Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Gallus gallus)
        
        Adenylate cyclase [plasma membrane] (Gallus gallus)
        
        ADCY2 [plasma membrane] (Gallus gallus)
- Signaling by Hedgehog (Gallus gallus)
  - Hedgehog 'off' state (Gallus gallus)
    - GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Gallus gallus)
      - adenylate cyclases:Mg2+ [plasma membrane] (Gallus gallus)
        
        adenylate cyclases [plasma membrane] (Gallus gallus)
        
        ADCY2 [plasma membrane] (Gallus gallus)

External Reference Information

External Reference

UniProt:E1BX91

Reference Genes

BioGPS Gene:420935

ENSEMBL:ENSGALG00010000808.1

KEGG:gga:420935

Monarch:420935

NCBI Gene:420935

UCSC:E1BX91

Reference Transcript

Other Identifiers

420935

GO:0003824

GO:0004016

GO:0005737

GO:0005886

GO:0006171

GO:0009190

GO:0009975

GO:0016829

GO:0016849

GO:0035556

GO:0055086

GO:1901135

GT_A_87_P103303

GgaAffx.8289.3.S1_s_at

GgaAffx.8289.7.S1_s_at

Participates

as a candidate of

adenylate cyclases [plasma membrane] (Gallus gallus)

as a member of

Adenylate cyclase [plasma membrane] (Gallus gallus)

Inferred From

ADCY2 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_015137790.1, XP_040519316.1

ENSEMBL

ENSGALP00010000976, ENSGALG00010000808, ENSGALT00010001775

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