Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
ITGB3BP [cytosol]
Stable Identifier
R-GGA-3006405
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
ITGB3BP, A0A8V1A0Y2
Locations in the PathwayBrowser
Expand all
Cell Cycle (Gallus gallus)
Cell Cycle Checkpoints (Gallus gallus)
Mitotic Spindle Checkpoint (Gallus gallus)
Amplification of signal from the kinetochores (Gallus gallus)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Gallus gallus)
MAD2 associates with the Mad1 kinetochore complex (Gallus gallus)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Gallus gallus)
Mad1:kinetochore complex [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
CCAN network [cytosol] (Gallus gallus)
CENP-O complex [cytosol] (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
Mad1:kinetochore complex [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
CCAN network [cytosol] (Gallus gallus)
CENP-O complex [cytosol] (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
MAD2 converted to an inhibitory state via interaction with Mad1 (Gallus gallus)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Gallus gallus)
Mad1:kinetochore complex [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
CCAN network [cytosol] (Gallus gallus)
CENP-O complex [cytosol] (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
Mad1 binds kinetochore (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
CCAN network [cytosol] (Gallus gallus)
CENP-O complex [cytosol] (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
Mad1:kinetochore complex [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
CCAN network [cytosol] (Gallus gallus)
CENP-O complex [cytosol] (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
Release of activated MAD2 from kinetochores (Gallus gallus)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Gallus gallus)
Mad1:kinetochore complex [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
CCAN network [cytosol] (Gallus gallus)
CENP-O complex [cytosol] (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
Mad1:kinetochore complex [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
CCAN network [cytosol] (Gallus gallus)
CENP-O complex [cytosol] (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
Cell Cycle, Mitotic (Gallus gallus)
M Phase (Gallus gallus)
Mitotic Metaphase and Anaphase (Gallus gallus)
Mitotic Anaphase (Gallus gallus)
Separation of Sister Chromatids (Gallus gallus)
ESPL1 (Separase) cleaves centromeric cohesin (Gallus gallus)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
CCAN network [cytosol] (Gallus gallus)
CENP-O complex [cytosol] (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
Microtubule-bound kinetochore [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
CCAN network [cytosol] (Gallus gallus)
CENP-O complex [cytosol] (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
Mitotic Prometaphase (Gallus gallus)
EML4 and NUDC in mitotic spindle formation (Gallus gallus)
EML4 recruits NUDC to mitotic spindle (Gallus gallus)
Microtubule-bound kinetochore [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
CCAN network [cytosol] (Gallus gallus)
CENP-O complex [cytosol] (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Gallus gallus)
Microtubule-bound kinetochore [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
CCAN network [cytosol] (Gallus gallus)
CENP-O complex [cytosol] (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
Resolution of Sister Chromatid Cohesion (Gallus gallus)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Gallus gallus)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Gallus gallus)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
CCAN network [cytosol] (Gallus gallus)
CENP-O complex [cytosol] (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
CCAN network [cytosol] (Gallus gallus)
CENP-O complex [cytosol] (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
Microtubule-bound kinetochore [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
CCAN network [cytosol] (Gallus gallus)
CENP-O complex [cytosol] (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
Kinetochore assembly (Gallus gallus)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Gallus gallus)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
CCAN network [cytosol] (Gallus gallus)
CENP-O complex [cytosol] (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
CCAN network [cytosol] (Gallus gallus)
CENP-O complex [cytosol] (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
Microtubule-bound kinetochore [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
CCAN network [cytosol] (Gallus gallus)
CENP-O complex [cytosol] (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
PP2A-B56 dephosphorylates centromeric cohesin (Gallus gallus)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
Microtubule-bound kinetochore [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
CCAN network [cytosol] (Gallus gallus)
CENP-O complex [cytosol] (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
Microtubule-bound kinetochore [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
CCAN network [cytosol] (Gallus gallus)
CENP-O complex [cytosol] (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
Phosphorylation of cohesin by PLK1 at centromeres (Gallus gallus)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
Microtubule-bound kinetochore [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
CCAN network [cytosol] (Gallus gallus)
CENP-O complex [cytosol] (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
Microtubule-bound kinetochore [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
CCAN network [cytosol] (Gallus gallus)
CENP-O complex [cytosol] (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Death Receptor Signaling (Gallus gallus)
p75 NTR receptor-mediated signalling (Gallus gallus)
Cell death signalling via NRAGE, NRIF and NADE (Gallus gallus)
NRIF signals cell death from the nucleus (Gallus gallus)
Polyubiquitinated NRIF binds to p62 (Sequestosome) (Gallus gallus)
Ubiquitinated NRIF [cytosol] (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
Ubiquitinated NRIF:Sequestosome [cytosol] (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
Polyubiquitinated NRIF migrates to the nucleus (Gallus gallus)
Ubiquitinated NRIF:Sequestosome [cytosol] (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
TRAF6 binds to p75NTR:NRIF (Gallus gallus)
NGF ligand:p75NTR:NRIF [plasma membrane] (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Gallus gallus)
NGF ligand:p75NTR:NRIF [plasma membrane] (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
TRAF6 polyubiquitinates NRIF (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
Ubiquitinated NRIF [cytosol] (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Gallus gallus)
NGF ligand:p75NTR:NRIF [plasma membrane] (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Gallus gallus)
Signaling by Rho GTPases (Gallus gallus)
RHO GTPase Effectors (Gallus gallus)
RHO GTPases Activate Formins (Gallus gallus)
AURKB phosphorylates DIAPH2-2 at kinetochores (Gallus gallus)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
CCAN network [cytosol] (Gallus gallus)
CENP-O complex [cytosol] (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
CCAN network [cytosol] (Gallus gallus)
CENP-O complex [cytosol] (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
CCAN network [cytosol] (Gallus gallus)
CENP-O complex [cytosol] (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Gallus gallus)
Kinetochore [cytosol] (Gallus gallus)
CCAN network [cytosol] (Gallus gallus)
CENP-O complex [cytosol] (Gallus gallus)
ITGB3BP [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:A0A8V1A0Y2
Gene Names
ITGB3BP
Reference Genes
ENSEMBL:ENSGALG00010024277.1
UCSC:A0A8V1A0Y2 ITGB3BP
Other Identifiers
424689
GO:0000939
GO:0005654
GO:0006325
GO:0006355
GO:0034080
GT_A_87_P024771
GT_A_87_P054061
Gga.11314.1.S1_at
Participates
as an input of
TRAF6 polyubiquitinates NRIF (Gallus gallus)
as an output of
gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Gallus gallus)
as a component of
Ubiquitinated NRIF [cytosol] (Gallus gallus)
Ubiquitinated NRIF:Sequestosome [cytosol] (Gallus gallus)
NGF ligand:p75NTR:NRIF [plasma membrane] (Gallus gallus)
CENP-O complex [cytosol] (Gallus gallus)
Other forms of this molecule
ITGB3BP [nucleoplasm]
Inferred From
ITGB3BP [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSGALT00010059237
,
ENSGALG00010024277
,
ENSGALP00010036158
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text