Reactome | EFNA2 [plasma membrane]

EFNA2 [plasma membrane]

Stable Identifier

R-GGA-2682320

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

plasma membrane

Synonyms

EFNA2, A0A1D5NZN5

Locations in the PathwayBrowser

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Developmental Biology (Gallus gallus)

- Nervous system development (Gallus gallus)
  - Axon guidance (Gallus gallus)
    - EPH-Ephrin signaling (Gallus gallus)
      - EPH receptors autophosphorylate (Gallus gallus)
        
        EPH-ephrin oligomers [plasma membrane] (Gallus gallus)
        
        EPHA:EFNA oligomers [plasma membrane] (Gallus gallus)
        
        EPHAs:EFNAs [plasma membrane] (Gallus gallus)
        
        EFNAs [plasma membrane] (Gallus gallus)
        
        EFNA2 [plasma membrane] (Gallus gallus)
        
        p-EPH:ephrin oligomers [plasma membrane] (Gallus gallus)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Gallus gallus)
        
        p-EPHAs:EFNAs [plasma membrane] (Gallus gallus)
        
        EFNAs [plasma membrane] (Gallus gallus)
        
        EFNA2 [plasma membrane] (Gallus gallus)
      - EPH-ephrin mediated repulsion of cells (Gallus gallus)
        
        EPHA binds TIAM1 (Gallus gallus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Gallus gallus)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Gallus gallus)
        
        p-EPHAs:EFNAs [plasma membrane] (Gallus gallus)
        
        EFNAs [plasma membrane] (Gallus gallus)
        
        EFNA2 [plasma membrane] (Gallus gallus)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Gallus gallus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Gallus gallus)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Gallus gallus)
        
        p-EPHAs:EFNAs [plasma membrane] (Gallus gallus)
        
        EFNAs [plasma membrane] (Gallus gallus)
        
        EFNA2 [plasma membrane] (Gallus gallus)
        
        SFKs phosphorylate VAV2,3 (Gallus gallus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Gallus gallus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Gallus gallus)
        
        p-EPH:ephrin oligomers [plasma membrane] (Gallus gallus)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Gallus gallus)
        
        p-EPHAs:EFNAs [plasma membrane] (Gallus gallus)
        
        EFNAs [plasma membrane] (Gallus gallus)
        
        EFNA2 [plasma membrane] (Gallus gallus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Gallus gallus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Gallus gallus)
        
        p-EPH:ephrin oligomers [plasma membrane] (Gallus gallus)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Gallus gallus)
        
        p-EPHAs:EFNAs [plasma membrane] (Gallus gallus)
        
        EFNAs [plasma membrane] (Gallus gallus)
        
        EFNA2 [plasma membrane] (Gallus gallus)
        
        TIAM1 exchanges GTP for GDP on RAC1, activating it (Gallus gallus)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Gallus gallus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Gallus gallus)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Gallus gallus)
        
        p-EPHAs:EFNAs [plasma membrane] (Gallus gallus)
        
        EFNAs [plasma membrane] (Gallus gallus)
        
        EFNA2 [plasma membrane] (Gallus gallus)
        
        VAV exchanges GTP for GDP on RAC1, activating it (Gallus gallus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Gallus gallus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Gallus gallus)
        
        p-EPH:ephrin oligomers [plasma membrane] (Gallus gallus)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Gallus gallus)
        
        p-EPHAs:EFNAs [plasma membrane] (Gallus gallus)
        
        EFNAs [plasma membrane] (Gallus gallus)
        
        EFNA2 [plasma membrane] (Gallus gallus)
        
        p-EPHs bind VAV2,3 (Gallus gallus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Gallus gallus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Gallus gallus)
        
        p-EPH:ephrin oligomers [plasma membrane] (Gallus gallus)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Gallus gallus)
        
        p-EPHAs:EFNAs [plasma membrane] (Gallus gallus)
        
        EFNAs [plasma membrane] (Gallus gallus)
        
        EFNA2 [plasma membrane] (Gallus gallus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Gallus gallus)
        
        p-EPH:ephrin oligomers [plasma membrane] (Gallus gallus)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Gallus gallus)
        
        p-EPHAs:EFNAs [plasma membrane] (Gallus gallus)
        
        EFNAs [plasma membrane] (Gallus gallus)
        
        EFNA2 [plasma membrane] (Gallus gallus)
      - EPH:EFN dimers tetramerise (Gallus gallus)
        
        EPH-EFN dimers [plasma membrane] (Gallus gallus)
        
        EPHA:EFNA dimers [plasma membrane] (Gallus gallus)
        
        EPHAs:EFNAs [plasma membrane] (Gallus gallus)
        
        EFNAs [plasma membrane] (Gallus gallus)
        
        EFNA2 [plasma membrane] (Gallus gallus)
        
        EPHAs:EFNAs,EPHBs:EFNBs [plasma membrane] (Gallus gallus)
        
        EPHAs:EFNAs [plasma membrane] (Gallus gallus)
        
        EFNAs [plasma membrane] (Gallus gallus)
        
        EFNA2 [plasma membrane] (Gallus gallus)
      - EPH:EFN tetramers oligomerise (Gallus gallus)
        
        EPH-EFN dimers [plasma membrane] (Gallus gallus)
        
        EPHA:EFNA dimers [plasma membrane] (Gallus gallus)
        
        EPHAs:EFNAs [plasma membrane] (Gallus gallus)
        
        EFNAs [plasma membrane] (Gallus gallus)
        
        EFNA2 [plasma membrane] (Gallus gallus)
        
        EPH-ephrin oligomers [plasma membrane] (Gallus gallus)
        
        EPHA:EFNA oligomers [plasma membrane] (Gallus gallus)
        
        EPHAs:EFNAs [plasma membrane] (Gallus gallus)
        
        EFNAs [plasma membrane] (Gallus gallus)
        
        EFNA2 [plasma membrane] (Gallus gallus)
        
        EPHAs:EFNAs,EPHBs:EFNBs [plasma membrane] (Gallus gallus)
        
        EPHAs:EFNAs [plasma membrane] (Gallus gallus)
        
        EFNAs [plasma membrane] (Gallus gallus)
        
        EFNA2 [plasma membrane] (Gallus gallus)
      - EPHA-mediated growth cone collapse (Gallus gallus)
        
        NGEF exchanges GTP for GDP on RHOA (Gallus gallus)
        
        EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Gallus gallus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Gallus gallus)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Gallus gallus)
        
        p-EPHAs:EFNAs [plasma membrane] (Gallus gallus)
        
        EFNAs [plasma membrane] (Gallus gallus)
        
        EFNA2 [plasma membrane] (Gallus gallus)
      - EPHAs bind EFNAs (Gallus gallus)
        
        EFNAs [plasma membrane] (Gallus gallus)
        
        EFNA2 [plasma membrane] (Gallus gallus)
        
        EPHAs:EFNAs [plasma membrane] (Gallus gallus)
        
        EFNAs [plasma membrane] (Gallus gallus)
        
        EFNA2 [plasma membrane] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A1D5NZN5

Gene Names

EFNA2

Reference Genes

ENSEMBL:ENSGALG00010028029.1

UCSC:A0A1D5NZN5 EFNA2

Other Identifiers

395831

GO:0005886

GO:0007411

GO:0016020

GO:0030154

GO:0030316

GO:0046849

GO:0046875

GO:0048013

GO:0098552

GT_A_87_P009460

Gga.2416.1.S1_at

Participates

as a member of

EFNAs [plasma membrane] (Gallus gallus)

Inferred From

EFNA2 [plasma membrane] (Homo sapiens)

Cross References

ENSEMBL

ENSGALT00010067928, ENSGALG00010028029, ENSGALP00010041671

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