Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PSEN1 [plasma membrane]
Stable Identifier
R-GGA-2534245
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
plasma membrane
Synonyms
PSEN1(299-467), A0A3Q2UE42
Locations in the PathwayBrowser
Expand all
Developmental Biology (Gallus gallus)
Nervous system development (Gallus gallus)
Axon guidance (Gallus gallus)
EPH-Ephrin signaling (Gallus gallus)
EPH-ephrin mediated repulsion of cells (Gallus gallus)
gamma-secretase cleaves EPHB2 (Gallus gallus)
gamma-secretase complex [plasma membrane] (Gallus gallus)
Presenilin [plasma membrane] (Gallus gallus)
PSEN1 [plasma membrane] (Gallus gallus)
PSEN1 [plasma membrane] (Gallus gallus)
Signal Transduction (Gallus gallus)
Death Receptor Signaling (Gallus gallus)
p75 NTR receptor-mediated signalling (Gallus gallus)
Cell death signalling via NRAGE, NRIF and NADE (Gallus gallus)
NRIF signals cell death from the nucleus (Gallus gallus)
gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Gallus gallus)
gamma-secretase complex [plasma membrane] (Gallus gallus)
Presenilin [plasma membrane] (Gallus gallus)
PSEN1 [plasma membrane] (Gallus gallus)
PSEN1 [plasma membrane] (Gallus gallus)
Regulated proteolysis of p75NTR (Gallus gallus)
gamma-secretase cleaves the p75NTR transmembrane domain (Gallus gallus)
gamma-secretase complex [plasma membrane] (Gallus gallus)
Presenilin [plasma membrane] (Gallus gallus)
PSEN1 [plasma membrane] (Gallus gallus)
PSEN1 [plasma membrane] (Gallus gallus)
Signaling by NOTCH (Gallus gallus)
Signaling by NOTCH3 (Gallus gallus)
NOTCH3 Activation and Transmission of Signal to the Nucleus (Gallus gallus)
NEXT3 is cleaved to produce NICD3 (Gallus gallus)
Presenilin [plasma membrane] (Gallus gallus)
PSEN1 [plasma membrane] (Gallus gallus)
PSEN1 [plasma membrane] (Gallus gallus)
gamma-secretase complex [plasma membrane] (Gallus gallus)
Presenilin [plasma membrane] (Gallus gallus)
PSEN1 [plasma membrane] (Gallus gallus)
PSEN1 [plasma membrane] (Gallus gallus)
Noncanonical activation of NOTCH3 (Gallus gallus)
Gamma-secretase cleaves YBX1:NOTCH3 (Gallus gallus)
Presenilin [plasma membrane] (Gallus gallus)
PSEN1 [plasma membrane] (Gallus gallus)
PSEN1 [plasma membrane] (Gallus gallus)
gamma-secretase complex [plasma membrane] (Gallus gallus)
Presenilin [plasma membrane] (Gallus gallus)
PSEN1 [plasma membrane] (Gallus gallus)
PSEN1 [plasma membrane] (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by ERBB4 (Gallus gallus)
Nuclear signaling by ERBB4 (Gallus gallus)
Cleavage of ERBB4m80 by gamma-scretase complex (Gallus gallus)
gamma-secretase complex [plasma membrane] (Gallus gallus)
Presenilin [plasma membrane] (Gallus gallus)
PSEN1 [plasma membrane] (Gallus gallus)
PSEN1 [plasma membrane] (Gallus gallus)
Signaling by TGFB family members (Gallus gallus)
Signaling by TGFBR3 (Gallus gallus)
TGFBR3 PTM regulation (Gallus gallus)
TGFBR3(784-851) degradation (Gallus gallus)
gamma-secretase complex [plasma membrane] (Gallus gallus)
Presenilin [plasma membrane] (Gallus gallus)
PSEN1 [plasma membrane] (Gallus gallus)
PSEN1 [plasma membrane] (Gallus gallus)
External Reference Information
External Reference
UniProt:A0A3Q2UE42
Gene Names
PSEN1
Reference Genes
BioGPS Gene:373977 PSEN1
ENSEMBL:ENSGALG00010020984.1
Monarch:373977 PSEN1
NCBI Gene:373977 PSEN1
UCSC:A0A3Q2UE42 PSEN1
Reference Transcript
RefSeq:XM_046917628.1 PSEN1
RefSeq:XM_015286914.4 PSEN1
Other Identifiers
373977
GO:0000045
GO:0000122
GO:0000139
GO:0000776
GO:0001568
GO:0001708
GO:0001756
GO:0001764
GO:0001921
GO:0001947
GO:0002038
GO:0002244
GO:0002265
GO:0002286
GO:0002376
GO:0002573
GO:0004175
GO:0004190
GO:0005262
GO:0005634
GO:0005640
GO:0005654
GO:0005737
GO:0005739
GO:0005783
GO:0005789
GO:0005790
GO:0005791
GO:0005794
GO:0005813
GO:0005815
GO:0005886
GO:0005938
GO:0006355
GO:0006486
GO:0006508
GO:0006509
GO:0006839
GO:0006874
GO:0006914
GO:0006915
GO:0006974
GO:0006979
GO:0007155
GO:0007219
GO:0007220
GO:0007420
GO:0007507
GO:0007611
GO:0007613
GO:0008013
GO:0008233
GO:0009791
GO:0010467
GO:0010468
GO:0010628
GO:0010629
GO:0010975
GO:0015031
GO:0015871
GO:0016020
GO:0016080
GO:0016235
GO:0016485
GO:0016787
GO:0021795
GO:0021870
GO:0021904
GO:0021987
GO:0022008
GO:0030054
GO:0030154
GO:0030165
GO:0030182
GO:0030326
GO:0030424
GO:0030425
GO:0030426
GO:0030900
GO:0031410
GO:0031965
GO:0032436
GO:0032469
GO:0032760
GO:0032991
GO:0034205
GO:0034330
GO:0035253
GO:0035282
GO:0035556
GO:0040011
GO:0042059
GO:0042307
GO:0042500
GO:0042982
GO:0042987
GO:0042995
GO:0043005
GO:0043011
GO:0043025
GO:0043065
GO:0043066
GO:0043198
GO:0043226
GO:0043589
GO:0045121
GO:0045202
GO:0045296
GO:0045821
GO:0045893
GO:0048143
GO:0048167
GO:0048538
GO:0048666
GO:0048705
GO:0048854
GO:0048856
GO:0048870
GO:0050435
GO:0050673
GO:0050771
GO:0050808
GO:0050820
GO:0050852
GO:0050877
GO:0051117
GO:0051208
GO:0051402
GO:0051563
GO:0051604
GO:0051966
GO:0055074
GO:0055085
GO:0060075
GO:0060828
GO:0060999
GO:0070050
GO:0070588
GO:0070765
GO:0070851
GO:0097190
GO:0098609
GO:0098693
GO:0098712
GO:0098793
GO:0098794
GO:0098978
GO:0099175
GO:0140249
GO:1904646
GO:1905908
GO:1990535
GO:2000059
GO:2001234
GT_A_87_P058896
GT_A_87_P254218
Gga.3864.1.S1_at
Gga.3864.1.S2_at
Participates
as a component of
PSEN1 [plasma membrane] (Gallus gallus)
Other forms of this molecule
PSEN1 [plasma membrane]
PSEN1 [azurophil granule membrane]
PSEN1 [azurophil granule membrane]
PSEN1 [azurophil granule membrane]
PSEN1 [plasma membrane]
Inferred From
PSEN1(299-467) [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
XP_015142400.1
,
XP_046773584.1
ENSEMBL
ENSGALG00010020984
,
ENSGALP00010029948
,
ENSGALT00010050722
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text