Complement factor I inactivates C3b

Stable Identifier
R-GGA-2132276
Type
Reaction [transition]
Species
Gallus gallus
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Complement factor I (CFI) is a serine protease that inhibits the complement pathway by degrading extracellular C3b into inactive fragments iC3b and C3f. Factor H acts as cofactor of factor I proteolytic activity on C3b [Ross JD et al 1982; Masaki T et al 1992; Fukui A et al 2002; Nilsson SC et al 2010].

Predicted chicken CFI shows 51% amino acid sequence identity with its human counterpart. The chicken events of complement factor I activity have not been verified experimentally but are inferred from properties of the orthologous human proteins.

Literature References
PubMed ID Title Journal Year
12417021 Mapping of the sites responsible for factor I-cofactor activity for cleavage of C3b and C4b on human C4b-binding protein (C4bp) by deletion mutagenesis

Fukui, A, Yuasa-Nakagawa, T, Murakami, Y, Funami, K, Kishi, N, Matsuda, T, Fujita, T, Seya, T, Nagasawa, S

J. Biochem. 2002
1386357 Factor I-dependent inactivation of human complement C4b of the classical pathway by C3b/C4b receptor (CR1, CD35) and membrane cofactor protein (MCP, CD46)

Masaki, T, Matsumoto, M, Nakanishi, I, Yasuda, R, Seya, T

J Biochem 1992
6214588 Generation of three different fragments of bound C3 with purified factor I or serum. I. Requirements for factor H vs CR1 cofactor activity

Ross, GD, Lambris, JD, Cain, JA, Newman, SL

J Immunol 1982
20044478 Analysis of binding sites on complement factor I that are required for its activity

Nilsson, SC, Nita, I, MÃ¥nsson, L, Groeneveld, TW, Trouw, LA, Villoutreix, BO, Blom, AM

J. Biol. Chem. 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of CFI [extracellular region]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created
Cite Us!