Formation of membrane-bound convertase C3

Stable Identifier
R-GGA-2132273
Type
Pathway
Species
Gallus gallus
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C3b, a product of the enzymatic action of C3 convertases on C3, is itself a constituent of the alternative pathway C3 convertase. It covalently binds to target cell membranes to initiate the formation of C3 convertase, which leads to a continuously cycling feedback loop.

Literature References
PubMed ID Title Journal Year
279011 Initiation of the alternative pathway of complement: recognition of activators by bound C3b and assembly of the entire pathway from six isolated proteins

Schreiber, RD, Pangburn, MK, Lesavre, PH, Muller-Eberhard, HJ

Proc Natl Acad Sci U S A 1978
268620 Interaction between the third complement protein and cell surface macromolecules

Law, SK, Levine, RP

Proc Natl Acad Sci U S A 1977
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