Reactome | H3-X [nucleoplasm]

H3-X [nucleoplasm]

Stable Identifier

R-GGA-212282

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

nucleoplasm

Synonyms

Me3K-28-H3F3A, P84247

Locations in the PathwayBrowser

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Cell-Cell communication (Gallus gallus)

- Cell junction organization (Gallus gallus)
  - Cell-cell junction organization (Gallus gallus)
    - Adherens junctions interactions (Gallus gallus)
      - Regulation of Homotypic Cell-Cell Adhesion (Gallus gallus)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Gallus gallus)
        
        Regulation of CDH1 Expression and Function (Gallus gallus)
        
        Regulation of CDH1 Gene Transcription (Gallus gallus)
        
        Negative Regulation of CDH1 Gene Transcription (Gallus gallus)
        
        PRC2 (EZH2) core complex methylates nucleosomes at CDH1 gene promoter (Gallus gallus)
        
        PRC2 (EZH2) Core:H3K27me3-Nucleosome:CDH1 gene [nucleoplasm] (Gallus gallus)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Gallus gallus)
        
        Histone H3 (H3K27me3) [nucleoplasm] (Gallus gallus)
        
        H3-X [nucleoplasm] (Gallus gallus)

Gene expression (Transcription) (Gallus gallus)

- Epigenetic regulation of gene expression (Gallus gallus)
  - PRC2 methylates histones and DNA (Gallus gallus)
    - DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Gallus gallus)
      - DNMT1,3A,3B:PRC2:Chromatin (5-mC, H3K27me3) [nucleoplasm] (Gallus gallus)
        
        PRC2:Chromatin (5-methylcytosine, H3K27me3) [nucleoplasm] (Gallus gallus)
        
        Chromatin with hemimethylC, H3K27me3 [nucleoplasm] (Gallus gallus)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Gallus gallus)
        
        Histone H3 (H3K27me3) [nucleoplasm] (Gallus gallus)
        
        H3-X [nucleoplasm] (Gallus gallus)
    - PRC2 trimethylates histone H3 at lysine-27 (Gallus gallus)
      - PRC2:Chromatin (H3K27me3) [nucleoplasm] (Gallus gallus)
        
        Chromatin with trimethylated H3K27 [nucleoplasm] (Gallus gallus)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Gallus gallus)
        
        Histone H3 (H3K27me3) [nucleoplasm] (Gallus gallus)
        
        H3-X [nucleoplasm] (Gallus gallus)

External Reference Information

External Reference

UniProt:P84247

Gene Names

H3-X

Reference Genes

BioGPS Gene:396233 H3-X

ENSEMBL:ENSGALG00010008224

KEGG:gga:396233 H3-X

KEGG:gga:427887 H3-X

Monarch:396233 H3-X

NCBI Gene:396233 H3-X

UCSC:P84247 H3-X

Reference Transcript

RefSeq:NM_205296.1 H3-X

Other Identifiers

100859629

396233

427887

GO:0000786

GO:0003677

GO:0005198

GO:0005634

GO:0005654

GO:0005694

GO:0030527

GO:0046982

GT_A_87_P008765

GT_A_87_P052556

GT_A_87_P097636

GT_A_87_P118138

GT_A_87_P189338

GT_Sp_Chicken_CO762256_7770

GT_Xhyb_Chicken_CN219025_1269

GT_Xhyb_Chicken_CN221753_2160

GT_Xhyb_Chicken_CN222993_2538

GT_Xhyb_Chicken_CN233395_3436

Gga.12912.1.S1_at

Gga.4770.1.S1_at

Gga.5274.1.S1_at

Gga.5274.2.S1_a_at

Participates

as a member of

Histone H3 (H3K27me3) [nucleoplasm] (Gallus gallus)

Other forms of this molecule

H3-X [nucleoplasm]

H3-X [extracellular region]

H3-X [nucleoplasm]

Inferred From

Me3K-28-H3F3A [nucleoplasm] (Homo sapiens)

Modified Residues

Name

N6,N6,N6-trimethyl-L-lysine at 28 (in Homo sapiens)

Coordinate

PsiMod Name

N6,N6,N6-trimethyl-L-lysine [MOD:00083]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6,N6,N6-trimethyl-L-lysine.

Cross References

RefSeq

NP_990627.1

ENSEMBL

ENSGALT00010042395, ENSGALT00010019662, ENSGALP00010011211, ENSGALG00010008224, ENSGALG00010017538, ENSGALP00010044750, ENSGALG00010029787, ENSGALT00010072060, ENSGALP00010024885

PRO

P84247

PDB

1PDQ