Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
GPC3 [plasma membrane]
Stable Identifier
R-GGA-2076660
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
plasma membrane
Synonyms
HS(1)-GPC3, A0A8V0Z0K9
Locations in the PathwayBrowser
Expand all
Hemostasis (Gallus gallus)
Coagulation pathway (Gallus gallus)
Initiation of coagulation cascade (Gallus gallus)
factor V -> factor Va intermediate + factor V activation peptide (FXa catalyst) (Gallus gallus)
FXa:SERPINC1:HS [plasma membrane] (Gallus gallus)
SERPINC1:HSPGs [plasma membrane] (Gallus gallus)
HSPGs [plasma membrane] (Gallus gallus)
HS(1)-PGs [plasma membrane] (Gallus gallus)
GPC3 [plasma membrane] (Gallus gallus)
Regulation of clotting cascade (Gallus gallus)
FXa binds SERPINC1:HS (Gallus gallus)
FXa:SERPINC1:HS [plasma membrane] (Gallus gallus)
SERPINC1:HSPGs [plasma membrane] (Gallus gallus)
HSPGs [plasma membrane] (Gallus gallus)
HS(1)-PGs [plasma membrane] (Gallus gallus)
GPC3 [plasma membrane] (Gallus gallus)
SERPINC1:HSPGs [plasma membrane] (Gallus gallus)
HSPGs [plasma membrane] (Gallus gallus)
HS(1)-PGs [plasma membrane] (Gallus gallus)
GPC3 [plasma membrane] (Gallus gallus)
SERPINC1 binds heparan sulfate (Gallus gallus)
HSPGs [plasma membrane] (Gallus gallus)
HS(1)-PGs [plasma membrane] (Gallus gallus)
GPC3 [plasma membrane] (Gallus gallus)
SERPINC1:HSPGs [plasma membrane] (Gallus gallus)
HSPGs [plasma membrane] (Gallus gallus)
HS(1)-PGs [plasma membrane] (Gallus gallus)
GPC3 [plasma membrane] (Gallus gallus)
activated thrombin (factor IIa) + antithrombin III:heparan sulfate -> thrombin:antithrombin III:heparan sulfate (Gallus gallus)
SERPINC1:HSPGs [plasma membrane] (Gallus gallus)
HSPGs [plasma membrane] (Gallus gallus)
HS(1)-PGs [plasma membrane] (Gallus gallus)
GPC3 [plasma membrane] (Gallus gallus)
thrombin:SERPINC1:HSPGs [plasma membrane] (Gallus gallus)
SERPINC1:HSPGs [plasma membrane] (Gallus gallus)
HSPGs [plasma membrane] (Gallus gallus)
HS(1)-PGs [plasma membrane] (Gallus gallus)
GPC3 [plasma membrane] (Gallus gallus)
thrombin:antithrombin III:heparan sulfate -> thrombin:cleaved antithrombin III:heparan sulfate (Gallus gallus)
thrombin:SERPINC1:HSPGs [plasma membrane] (Gallus gallus)
SERPINC1:HSPGs [plasma membrane] (Gallus gallus)
HSPGs [plasma membrane] (Gallus gallus)
HS(1)-PGs [plasma membrane] (Gallus gallus)
GPC3 [plasma membrane] (Gallus gallus)
thrombin:cleaved SERPINC1:HSPGs [plasma membrane] (Gallus gallus)
HSPGs [plasma membrane] (Gallus gallus)
HS(1)-PGs [plasma membrane] (Gallus gallus)
GPC3 [plasma membrane] (Gallus gallus)
thrombin:cleaved SERPINC1:HSPGs-> thrombin:cleaved SERPINC1 + HSPGs (Gallus gallus)
HSPGs [plasma membrane] (Gallus gallus)
HS(1)-PGs [plasma membrane] (Gallus gallus)
GPC3 [plasma membrane] (Gallus gallus)
thrombin:cleaved SERPINC1:HSPGs [plasma membrane] (Gallus gallus)
HSPGs [plasma membrane] (Gallus gallus)
HS(1)-PGs [plasma membrane] (Gallus gallus)
GPC3 [plasma membrane] (Gallus gallus)
Metabolism (Gallus gallus)
Metabolism of carbohydrates and carbohydrate derivatives (Gallus gallus)
Glycosaminoglycan metabolism (Gallus gallus)
Heparan sulfate/heparin (HS-GAG) metabolism (Gallus gallus)
HS-GAG biosynthesis (Gallus gallus)
Some HSPGs are secreted to the plasma membrane (Gallus gallus)
HSPGs [plasma membrane] (Gallus gallus)
HS(1)-PGs [plasma membrane] (Gallus gallus)
GPC3 [plasma membrane] (Gallus gallus)
External Reference Information
External Reference
UniProt:A0A8V0Z0K9
Gene Names
GPC3
Reference Genes
BioGPS Gene:770863 GPC3
ENSEMBL:ENSGALG00010017409.1
Monarch:770863 GPC3
NCBI Gene:770863 GPC3
UCSC:A0A8V0Z0K9 GPC3
Reference Transcript
RefSeq:XM_025150250.3 GPC3
Other Identifiers
770863
GO:0001658
GO:0001822
GO:0005764
GO:0005886
GO:0007224
GO:0008285
GO:0009617
GO:0009887
GO:0009948
GO:0009966
GO:0009986
GO:0010171
GO:0016020
GO:0016477
GO:0030154
GO:0030282
GO:0030312
GO:0030316
GO:0030324
GO:0030513
GO:0031012
GO:0035116
GO:0040008
GO:0045732
GO:0045807
GO:0045879
GO:0045880
GO:0045926
GO:0046326
GO:0048856
GO:0048870
GO:0050673
GO:0050680
GO:0060070
GO:0060071
GO:0060422
GO:0060828
GO:0060976
GO:0062023
GO:0072111
GO:0072138
GO:0072180
GO:0072203
GO:0090090
GO:0090263
GO:0098552
GO:0098772
GO:1905475
GO:2000050
GO:2000096
GT_A_87_P094071
GT_A_87_P268748
GgaAffx.3795.1.S1_at
Participates
as a member of
HS(1)-PGs [plasma membrane] (Gallus gallus)
Other forms of this molecule
GPC3 [plasma membrane]
GPC3 [plasma membrane]
GPC3 [plasma membrane]
GPC3 [plasma membrane]
GPC3 [plasma membrane]
GPC3 [endoplasmic reticulum lumen]
phospho-GPC3 [endoplasmic reticulum lumen]
GPC3 [Golgi lumen]
GPC3 [Golgi lumen]
GPC3 [Golgi lumen]
GPC3 [Golgi lumen]
GPC3 [Golgi lumen]
GPC3 [Golgi lumen]
GPC3 [Golgi lumen]
GPC3 [Golgi lumen]
GPC3 [Golgi lumen]
GPC3 [Golgi lumen]
GPC3 [Golgi lumen]
GPC3 [Golgi lumen]
GPC3 [Golgi lumen]
GPC3 [Golgi lumen]
GPC3 [Golgi lumen]
GPC3 [Golgi lumen]
GPC3 [lysosomal lumen]
GPC3 [Golgi lumen]
Inferred From
HS(1)-GPC3 [plasma membrane]
(Homo sapiens)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63652) at unknown position
Modification
beta-D-GlcA-(1->4)-alpha-D-GlcNS-(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNS-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
XP_025006018.2
ENSEMBL
ENSGALP00010024593
,
ENSGALT00010042014
,
ENSGALG00010017409
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text