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p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm]
Stable Identifier
R-GGA-206827
Type
Complex
Species
Gallus gallus
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Developmental Biology (Gallus gallus)
Signaling by NODAL (Gallus gallus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
Gene expression (Transcription) (Gallus gallus)
RNA Polymerase II Transcription (Gallus gallus)
Generic Transcription Pathway (Gallus gallus)
FOXO-mediated transcription (Gallus gallus)
FOXO-mediated transcription of cell cycle genes (Gallus gallus)
FOXG1 binds FOXO:SMAD complexes (Gallus gallus)
FOXG1:FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Gallus gallus)
FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Gallus gallus)
FOXO1,FOXO3,FOXO4:p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Gallus gallus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Gallus gallus)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Gallus gallus)
p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
PARP1 binds SMAD2/3:SMAD4 heterotrimer (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
PPM1A dephosphorylates nuclear SMAD2/3 (Gallus gallus)
p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
p-SMAD2,3:SMAD4:TRIM33 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
TRIM33 monoubiquitinates SMAD4 (Gallus gallus)
p-SMAD2,3:SMAD4:TRIM33 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Gallus gallus)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
SMAD2/3:SMAD4 heterotrimer binds SP1 (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4:SP1 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
WWTR1:SMAD translocates to the nucleus (Gallus gallus)
WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
Signal Transduction (Gallus gallus)
Signaling by TGFB family members (Gallus gallus)
Signaling by Activin (Gallus gallus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
Signaling by TGF-beta Receptor Complex (Gallus gallus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Gallus gallus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Gallus gallus)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Gallus gallus)
p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
PARP1 binds SMAD2/3:SMAD4 heterotrimer (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
PPM1A dephosphorylates nuclear SMAD2/3 (Gallus gallus)
p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
p-SMAD2,3:SMAD4:TRIM33 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
TRIM33 monoubiquitinates SMAD4 (Gallus gallus)
p-SMAD2,3:SMAD4:TRIM33 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Gallus gallus)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
SMAD2/3:SMAD4 heterotrimer binds SP1 (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4:SP1 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
WWTR1:SMAD translocates to the nucleus (Gallus gallus)
WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Gallus gallus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
Homologues of p-S465,S467-SMAD2 [nucleoplasm]
(Gallus gallus)
Homologues of SMAD4 [nucleoplasm]
(Gallus gallus)
Participates
as a member of
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Gallus gallus)
Inferred From
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm]
(Homo sapiens)
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