Reactome | SOCS1 [cytosol]

SOCS1 [cytosol]

Stable Identifier

R-GGA-204910

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

SOCS1, B6RCQ2

Locations in the PathwayBrowser

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Immune System (Gallus gallus)

- Adaptive Immune System (Gallus gallus)
  - Class I MHC mediated antigen processing & presentation (Gallus gallus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Gallus gallus)
      - Interaction of E3 with substrate and E2-Ub complex (Gallus gallus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Gallus gallus)
        
        SOCS-1 and SOCS-3 [cytosol] (Gallus gallus)
        
        SOCS1 [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Gallus gallus)
        
        SOCS-1 and SOCS-3 [cytosol] (Gallus gallus)
        
        SOCS1 [cytosol] (Gallus gallus)
      - Polyubiquitination of substrate (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Gallus gallus)
        
        SOCS-1 and SOCS-3 [cytosol] (Gallus gallus)
        
        SOCS1 [cytosol] (Gallus gallus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Gallus gallus)
        
        SOCS-1 and SOCS-3 [cytosol] (Gallus gallus)
        
        SOCS1 [cytosol] (Gallus gallus)
        
        E3:Ub:substrate [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Gallus gallus)
        
        SOCS-1 and SOCS-3 [cytosol] (Gallus gallus)
        
        SOCS1 [cytosol] (Gallus gallus)
      - Release of E3 from polyubiquitinated substrate (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Gallus gallus)
        
        SOCS-1 and SOCS-3 [cytosol] (Gallus gallus)
        
        SOCS1 [cytosol] (Gallus gallus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Gallus gallus)
        
        SOCS-1 and SOCS-3 [cytosol] (Gallus gallus)
        
        SOCS1 [cytosol] (Gallus gallus)
      - Transfer of Ub from E2 to substrate and release of E2 (Gallus gallus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Gallus gallus)
        
        SOCS-1 and SOCS-3 [cytosol] (Gallus gallus)
        
        SOCS1 [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Gallus gallus)
        
        SOCS-1 and SOCS-3 [cytosol] (Gallus gallus)
        
        SOCS1 [cytosol] (Gallus gallus)
        
        E3:Ub:substrate [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Gallus gallus)
        
        SOCS-1 and SOCS-3 [cytosol] (Gallus gallus)
        
        SOCS1 [cytosol] (Gallus gallus)
- Cytokine Signaling in Immune system (Gallus gallus)
  - Interferon Signaling (Gallus gallus)
    - Interferon alpha/beta signaling (Gallus gallus)
      - Activation of JAK kinases (Gallus gallus)
        
        p-TYK2:p-IFNAR1:SOCS-1/SOCS-3:IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Gallus gallus)
        
        p-IFNAR1:p-TYK2:SOCS-1/SOCS-3 [plasma membrane] (Gallus gallus)
        
        SOCS-1 and SOCS-3 [cytosol] (Gallus gallus)
        
        SOCS1 [cytosol] (Gallus gallus)
    - Interferon gamma signaling (Gallus gallus)
      - Regulation of IFNG signaling (Gallus gallus)
        
        SOCS-1 and SOCS-3 binds to p-JAK2 (Gallus gallus)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Gallus gallus)
        
        SOCS-1 and SOCS-3 [cytosol] (Gallus gallus)
        
        SOCS1 [cytosol] (Gallus gallus)
        
        SOCS-1 and SOCS-3 [cytosol] (Gallus gallus)
        
        SOCS1 [cytosol] (Gallus gallus)
      - Transphosphorylation of JAK1 (Gallus gallus)
        
        IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] (Gallus gallus)
        
        SOCS-1 and SOCS-3 [cytosol] (Gallus gallus)
        
        SOCS1 [cytosol] (Gallus gallus)
  - Signaling by Interleukins (Gallus gallus)
    - Interleukin-4 and Interleukin-13 signaling (Gallus gallus)
      - SOCS5,(SOCS1) bind IL4RA (Gallus gallus)
        
        IL4:IL4R:JAK2:IL13RA:TYK2:SOCS5,(SOCS1) [plasma membrane] (Gallus gallus)
        
        SOCS5,(SOCS1) [cytosol] (Gallus gallus)
        
        SOCS1 [cytosol] (Gallus gallus)
        
        SOCS5,(SOCS1) [cytosol] (Gallus gallus)
        
        SOCS1 [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:B6RCQ2

Gene Names

SOCS1

Reference Genes

BioGPS Gene:416630 SOCS1

ENSEMBL:ENSGALG00010019269.1

KEGG:gga:416630 SOCS1

Monarch:416630 SOCS1

NCBI Gene:416630 SOCS1

UCSC:B6RCQ2 SOCS1

Reference Transcript

Other Identifiers

416630

GO:0001817

GO:0005126

GO:0005159

GO:0005634

GO:0005654

GO:0007259

GO:0009968

GO:0016567

GO:0019210

GO:0019221

GO:0019901

GO:0030154

GO:0030225

GO:0031410

GO:0032502

GO:0035556

GO:0043372

GO:0043377

GO:0045444

GO:0045591

GO:0046425

GO:0046426

GO:0046627

GO:0071230

GO:0098772

GT_A_87_P057376

GT_A_87_P151233

Gga.10606.1.S1_at

Participates

as a candidate of

SOCS5,(SOCS1) [cytosol] (Gallus gallus)

as a member of

SOCS-1 and SOCS-3 [cytosol] (Gallus gallus)

Inferred From

SOCS1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_046783428.1, NP_001131120.1, XP_046783429.1, XP_046756609.1, XP_015149719.1

ENSEMBL

ENSGALP00010027749, ENSGALT00010046596, ENSGALP00010027754, ENSGALT00010046593, ENSGALP00010027751, ENSGALG00010019269, ENSGALT00010046591

PDB

6C7Y

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