Reactome | GRAP2 [cytosol]

GRAP2 [cytosol]

Stable Identifier

R-GGA-202367

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

GRAP2, E1BQF3

Locations in the PathwayBrowser

Expand all

Immune System (Gallus gallus)

- Adaptive Immune System (Gallus gallus)
  - Costimulation by the CD28 family (Gallus gallus)
    - CD28 co-stimulation (Gallus gallus)
      - Gads binds CD28 (Gallus gallus)
        
        CD28:GRAP2 [plasma membrane] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
  - TCR signaling (Gallus gallus)
    - Generation of second messenger molecules (Gallus gallus)
      - Phosphorylation of PLC-gamma1 (Gallus gallus)
        
        PLCG1:p-3Y-SLP-76:Gads:LAT [plasma membrane] (Gallus gallus)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Gallus gallus)
        
        GADS:p-5Y-LAT [plasma membrane] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
        
        phosphorylated PLC-gamma1 bound to SLP-76 [plasma membrane] (Gallus gallus)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Gallus gallus)
        
        GADS:p-5Y-LAT [plasma membrane] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
- Innate Immune System (Gallus gallus)
  - DAP12 interactions (Gallus gallus)
    - DAP12 signaling (Gallus gallus)
      - Activation of RAC1 by VAV2/3 (Gallus gallus)
        
        p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
      - Phosphorylation and activation of VAV2/VAV3 by SYK (Gallus gallus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
        
        p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
      - Phosphorylation of BTK by p-SYK (Gallus gallus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
      - Phosphorylation of PLC-gamma by p-BTK/p-SYK (Gallus gallus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Gallus gallus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
        
        p-SYK/p-BTK [plasma membrane] (Gallus gallus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
      - Phosphorylation of SLP-76 by p-SYK (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Gallus gallus)
        
        GADS:SLP76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
      - Recruitment of GADS:SLP-76 to p-5Y-LAT (Gallus gallus)
        
        GADS:SLP76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Gallus gallus)
        
        GADS:SLP76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
      - Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Gallus gallus)
        
        GADS:SLP76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Gallus gallus)
        
        GADS:SLP76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
      - Recruitment of VAV and BTK to p-SLP-76 (Gallus gallus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
      - Release of p-PLCG1 (Gallus gallus)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Gallus gallus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Gallus gallus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
  - Fc epsilon receptor (FCERI) signaling (Gallus gallus)
    - FCERI mediated Ca+2 mobilization (Gallus gallus)
      - Autophosphorylation of BTK/ITK (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
      - Hydrolysis of PIP2 by PLCG (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Gallus gallus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
    - FCERI mediated MAPK activation (Gallus gallus)
      - Activation of RAC1 by VAV (Gallus gallus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
      - Autophosphorylation of PAK (Gallus gallus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Gallus gallus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
      - Phosphorylation and activation of VAV (Gallus gallus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
      - Recruitment of GADS:SLP-76 to p-5Y-LAT (Gallus gallus)
        
        GADS:SLP76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Gallus gallus)
        
        GADS:SLP76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
      - Recruitment of PAK to the membrane by binding active RAC1 (Gallus gallus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Gallus gallus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
      - Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Gallus gallus)
        
        GADS:SLP76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Gallus gallus)
        
        GADS:SLP76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
      - Recruitment of VAV to p-SLP-76 (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Gallus gallus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
        
        GRAP2 [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:E1BQF3

Gene Names

GRAP2

Reference Genes

BioGPS Gene:770756 GRAP2

ENSEMBL:ENSGALG00000012056

ENSEMBL:ENSGALG00010013194.1 GRAP2

KEGG Gene (Gallus gallus):770756 GRAP2

Monarch:770756 GRAP2

NCBI Gene:770756 GRAP2

Reference Transcript

Other Identifiers

770756

GO:0001784

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005886

GO:0007165

GO:0023052

GO:0043226

GO:0043408

GT_A_87_P035348

GT_A_87_P163283

Participates

as an input of

Gads binds CD28 (Gallus gallus)

as a component of

as a member of

Adapter proteins [cytosol] (Gallus gallus)

Inferred From

GRAP2 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_001234082.2, XP_004937789.1

OpenTargets

ENSG00000100351

Ensembl

ENSGALP00010018531, ENSGALT00010031672, ENSGALG00010013194

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