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phospho-LCP2 [cytosol]
Stable Identifier
R-GGA-202175
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
p-Y113,128,145-LCP2, A0A8V0YA21
Locations in the PathwayBrowser
Expand all
Hemostasis (Gallus gallus)
Platelet activation, signaling and aggregation (Gallus gallus)
GPVI-mediated activation cascade (Gallus gallus)
SLP-76 stimulates PLC gamma 2 (Gallus gallus)
phospho-LCP2 [cytosol] (Gallus gallus)
Syk activation leads to SLP-76 activation (Gallus gallus)
phospho-LCP2 [cytosol] (Gallus gallus)
p-SLP-76 binds VAV (Gallus gallus)
p-SLP-76:VAV [cytosol] (Gallus gallus)
phospho-LCP2 [cytosol] (Gallus gallus)
phospho-LCP2 [cytosol] (Gallus gallus)
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
TCR signaling (Gallus gallus)
Generation of second messenger molecules (Gallus gallus)
Phosphorylation of PLC-gamma1 (Gallus gallus)
ITK:p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Gallus gallus)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Gallus gallus)
phospho-LCP2 [cytosol] (Gallus gallus)
PLCG1:p-3Y-SLP-76:Gads:LAT [plasma membrane] (Gallus gallus)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Gallus gallus)
phospho-LCP2 [cytosol] (Gallus gallus)
phosphorylated PLC-gamma1 bound to SLP-76 [plasma membrane] (Gallus gallus)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Gallus gallus)
phospho-LCP2 [cytosol] (Gallus gallus)
p-SLP-76 binds ADAP (Gallus gallus)
p-SLP-76:ADAP [cytosol] (Gallus gallus)
phospho-LCP2 [cytosol] (Gallus gallus)
phospho-LCP2 [cytosol] (Gallus gallus)
Innate Immune System (Gallus gallus)
DAP12 interactions (Gallus gallus)
DAP12 signaling (Gallus gallus)
Activation of RAC1 by VAV2/3 (Gallus gallus)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-LCP2 [cytosol] (Gallus gallus)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-LCP2 [cytosol] (Gallus gallus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-LCP2 [cytosol] (Gallus gallus)
Recruitment of VAV and BTK to p-SLP-76 (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-LCP2 [cytosol] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-LCP2 [cytosol] (Gallus gallus)
Release of p-PLCG1 (Gallus gallus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-LCP2 [cytosol] (Gallus gallus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-LCP2 [cytosol] (Gallus gallus)
Fc epsilon receptor (FCERI) signaling (Gallus gallus)
FCERI mediated Ca+2 mobilization (Gallus gallus)
Autophosphorylation of BTK/ITK (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-LCP2 [cytosol] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-LCP2 [cytosol] (Gallus gallus)
Hydrolysis of PIP2 by PLCG (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-LCP2 [cytosol] (Gallus gallus)
Phosphorylation of TEC kinases by p-SYK (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-LCP2 [cytosol] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-LCP2 [cytosol] (Gallus gallus)
FCERI mediated MAPK activation (Gallus gallus)
Activation of RAC1 by VAV (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-LCP2 [cytosol] (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-LCP2 [cytosol] (Gallus gallus)
Autophosphorylation of PAK (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-LCP2 [cytosol] (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-LCP2 [cytosol] (Gallus gallus)
Phosphorylation and activation of VAV (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-LCP2 [cytosol] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-LCP2 [cytosol] (Gallus gallus)
Phosphorylation of SLP-76 by p-SYK (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-LCP2 [cytosol] (Gallus gallus)
Recruitment of PAK to the membrane by binding active RAC1 (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-LCP2 [cytosol] (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-LCP2 [cytosol] (Gallus gallus)
Recruitment of VAV to p-SLP-76 (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-LCP2 [cytosol] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-LCP2 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:A0A8V0YA21
Gene Names
LCP2
Reference Genes
ENSEMBL:ENSGALG00010010742.1
UCSC:A0A8V0YA21 LCP2
Other Identifiers
395438
GO:0002376
GO:0005515
GO:0005737
GO:0005829
GO:0005911
GO:0036398
GO:0044853
GO:0045576
GO:0050852
Gga.236.1.S1_at
Participates
as an input of
p-SLP-76 binds VAV (Gallus gallus)
p-SLP-76 binds ADAP (Gallus gallus)
as a component of
p-SLP-76:VAV [cytosol] (Gallus gallus)
p-SLP-76:ADAP [cytosol] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Gallus gallus)
as an output of
Syk activation leads to SLP-76 activation (Gallus gallus)
This entity regulates
Positively
SLP-76 stimulates PLC gamma 2
(Gallus gallus)
Other forms of this molecule
LCP2 [cytosol]
Inferred From
p-Y113,128,145-LCP2 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 113 (in Homo sapiens)
Coordinate
113
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 128 (in Homo sapiens)
Coordinate
128
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 145 (in Homo sapiens)
Coordinate
145
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
ENSEMBL
ENSGALG00010010742
,
ENSGALP00010014455
,
ENSGALT00010025647
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