Reactome | RPS6KA3 [nucleoplasm]

RPS6KA3 [nucleoplasm]

Stable Identifier

R-GGA-199869

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

nucleoplasm

Synonyms

A0A1D5PTW8

Locations in the PathwayBrowser

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Cellular responses to external stimuli (Gallus gallus)

- Cellular responses to stress (Gallus gallus)
  - Cellular Senescence (Gallus gallus)
    - Senescence-Associated Secretory Phenotype (SASP) (Gallus gallus)
      - ERK1/2/5 activate RSK1/2/3 (Gallus gallus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Gallus gallus)
        
        RPS6KA3 [nucleoplasm] (Gallus gallus)

Immune System (Gallus gallus)

- Cytokine Signaling in Immune system (Gallus gallus)
  - Signaling by Interleukins (Gallus gallus)
    - Interleukin-17 signaling (Gallus gallus)
      - MAP kinase activation (Gallus gallus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
        
        ERK/MAPK targets (Gallus gallus)
        
        ERK1/2/5 activate RSK1/2/3 (Gallus gallus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Gallus gallus)
        
        RPS6KA3 [nucleoplasm] (Gallus gallus)
- Innate Immune System (Gallus gallus)
  - Toll-like Receptor Cascades (Gallus gallus)
    - Toll Like Receptor 10 (TLR10) Cascade (Gallus gallus)
      - MyD88 cascade initiated on plasma membrane (Gallus gallus)
        
        MAP kinase activation (Gallus gallus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
        
        ERK/MAPK targets (Gallus gallus)
        
        ERK1/2/5 activate RSK1/2/3 (Gallus gallus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Gallus gallus)
        
        RPS6KA3 [nucleoplasm] (Gallus gallus)
    - Toll Like Receptor 2 (TLR2) Cascade (Gallus gallus)
      - Toll Like Receptor TLR1:TLR2 Cascade (Gallus gallus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
        
        MAP kinase activation (Gallus gallus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
        
        ERK/MAPK targets (Gallus gallus)
        
        ERK1/2/5 activate RSK1/2/3 (Gallus gallus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Gallus gallus)
        
        RPS6KA3 [nucleoplasm] (Gallus gallus)
      - Toll Like Receptor TLR6:TLR2 Cascade (Gallus gallus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
        
        MAP kinase activation (Gallus gallus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
        
        ERK/MAPK targets (Gallus gallus)
        
        ERK1/2/5 activate RSK1/2/3 (Gallus gallus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Gallus gallus)
        
        RPS6KA3 [nucleoplasm] (Gallus gallus)
    - Toll Like Receptor 3 (TLR3) Cascade (Gallus gallus)
      - MAP kinase activation (Gallus gallus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
        
        ERK/MAPK targets (Gallus gallus)
        
        ERK1/2/5 activate RSK1/2/3 (Gallus gallus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Gallus gallus)
        
        RPS6KA3 [nucleoplasm] (Gallus gallus)
    - Toll Like Receptor 4 (TLR4) Cascade (Gallus gallus)
      - MyD88-independent TLR4 cascade (Gallus gallus)
        
        TRIF(TICAM1)-mediated TLR4 signaling (Gallus gallus)
        
        MAP kinase activation (Gallus gallus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
        
        ERK/MAPK targets (Gallus gallus)
        
        ERK1/2/5 activate RSK1/2/3 (Gallus gallus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Gallus gallus)
        
        RPS6KA3 [nucleoplasm] (Gallus gallus)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
        
        MAP kinase activation (Gallus gallus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
        
        ERK/MAPK targets (Gallus gallus)
        
        ERK1/2/5 activate RSK1/2/3 (Gallus gallus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Gallus gallus)
        
        RPS6KA3 [nucleoplasm] (Gallus gallus)
    - Toll Like Receptor 5 (TLR5) Cascade (Gallus gallus)
      - MyD88 cascade initiated on plasma membrane (Gallus gallus)
        
        MAP kinase activation (Gallus gallus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
        
        ERK/MAPK targets (Gallus gallus)
        
        ERK1/2/5 activate RSK1/2/3 (Gallus gallus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Gallus gallus)
        
        RPS6KA3 [nucleoplasm] (Gallus gallus)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Gallus gallus)
      - MyD88 dependent cascade initiated on endosome (Gallus gallus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Gallus gallus)
        
        MAP kinase activation (Gallus gallus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
        
        ERK/MAPK targets (Gallus gallus)
        
        ERK1/2/5 activate RSK1/2/3 (Gallus gallus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Gallus gallus)
        
        RPS6KA3 [nucleoplasm] (Gallus gallus)
    - Toll Like Receptor 9 (TLR9) Cascade (Gallus gallus)
      - MyD88 dependent cascade initiated on endosome (Gallus gallus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Gallus gallus)
        
        MAP kinase activation (Gallus gallus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
        
        ERK/MAPK targets (Gallus gallus)
        
        ERK1/2/5 activate RSK1/2/3 (Gallus gallus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Gallus gallus)
        
        RPS6KA3 [nucleoplasm] (Gallus gallus)

Signal Transduction (Gallus gallus)

- Signaling by GPCR (Gallus gallus)
  - GPCR downstream signalling (Gallus gallus)
    - G alpha (q) signalling events (Gallus gallus)
      - Gastrin-CREB signalling pathway via PKC and MAPK (Gallus gallus)
        
        ERK1/2/5 activate RSK1/2/3 (Gallus gallus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Gallus gallus)
        
        RPS6KA3 [nucleoplasm] (Gallus gallus)
- Signaling by Receptor Tyrosine Kinases (Gallus gallus)
  - Signaling by NTRKs (Gallus gallus)
    - Signaling by NTRK1 (TRKA) (Gallus gallus)
      - Nuclear Events (kinase and transcription factor activation) (Gallus gallus)
        
        ERK/MAPK targets (Gallus gallus)
        
        ERK1/2/5 activate RSK1/2/3 (Gallus gallus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Gallus gallus)
        
        RPS6KA3 [nucleoplasm] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A1D5PTW8

Reference Genes

ENSEMBL:ENSGALG00000016406

Other Identifiers

04150+2.7.11.1

04151+2.7.11.1

04714+2.7.11.1

04926+2.7.11.1

05163+2.7.11.1

05165+2.7.11.1

05170+2.7.11.1

418605

ENSGALG00000016406

ENSGALP00000044826

ENSGALP00000056368

ENSGALT00000052145

ENSGALT00000060518

EntrezGene:418605

Gga.12418.1.S1_s_at

Gga.12975.1.S1_s_at

GO:0000166

GO:0000287

GO:0002224

GO:0002376

GO:0003674

GO:0004672

GO:0004674

GO:0004711

GO:0005524

GO:0006464

GO:0006468

GO:0006915

GO:0007165

GO:0008219

GO:0016301

GO:0016310

GO:0016740

GO:0019899

GO:0019901

GO:0030234

GO:0032496

GO:0035556

GO:0043027

GO:0043154

GO:0043167

GO:0045944

GT_A_87_P118903

HGNC:10432

IPR000719

IPR000961

IPR008271

IPR011009

IPR016239

IPR017441

IPR017892

PF00069

PF00433

RPS6KA3

RPS6KA3-201

RPS6KA3-202

SM00133

SM00220

UPI0003504925

UPI0007776959

XM_015272662

XM_015272663

XM_025146577

XP_015128148

XP_015128149

XP_025002345

Participant Of

hasMember

Ribosomal protein S6 kinase [nucleoplasm]

Other forms of this molecule

phospho-p-4S,T231,T365-RPS6KA3 [nucleoplasm]

phospho-p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol]

phospho-p-S227,T365,S369,S386,T577,T737-RPS6KA3 [nucleoplasm]

Inferred From

RPS6KA3 [nucleoplasm] (Homo sapiens)