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PTEN [cytosol]
Stable Identifier
R-GGA-199420
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
F1NT98
Locations in the PathwayBrowser
Expand all
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
TCR signaling (Gallus gallus)
Downstream TCR signaling (Gallus gallus)
PTEN dephosphorylates PIP3 (Gallus gallus)
PTEN [cytosol] (Gallus gallus)
Metabolism (Gallus gallus)
Inositol phosphate metabolism (Gallus gallus)
Synthesis of IP3 and IP4 in the cytosol (Gallus gallus)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Gallus gallus)
PTEN:Mg2+ [cytosol] (Gallus gallus)
PTEN [cytosol] (Gallus gallus)
Metabolism of lipids (Gallus gallus)
Phospholipid metabolism (Gallus gallus)
PI Metabolism (Gallus gallus)
Synthesis of PIPs at the plasma membrane (Gallus gallus)
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Gallus gallus)
PTEN [cytosol] (Gallus gallus)
PTEN dephosphorylates PIP3 (Gallus gallus)
PTEN [cytosol] (Gallus gallus)
Metabolism of proteins (Gallus gallus)
Post-translational protein modification (Gallus gallus)
Deubiquitination (Gallus gallus)
Ovarian tumor domain proteases (Gallus gallus)
OTUD3 deubiquitinates PTEN (Gallus gallus)
PTEN [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Intracellular signaling by second messengers (Gallus gallus)
PIP3 activates AKT signaling (Gallus gallus)
Negative regulation of the PI3K/AKT network (Gallus gallus)
PTEN dephosphorylates PIP3 (Gallus gallus)
PTEN [cytosol] (Gallus gallus)
PTEN Regulation (Gallus gallus)
Regulation of PTEN localization (Gallus gallus)
Deubiquitinated PTEN translocates to the cytosol (Gallus gallus)
PTEN [cytosol] (Gallus gallus)
PTEN undergoes monoubiquitination (Gallus gallus)
PTEN [cytosol] (Gallus gallus)
Regulation of PTEN stability and activity (Gallus gallus)
FRK phosphorylates PTEN (Gallus gallus)
PTEN:p-Y387-FRK [cytosol] (Gallus gallus)
PTEN [cytosol] (Gallus gallus)
MKRN1 polyubiquitinates PTEN (Gallus gallus)
PTEN [cytosol] (Gallus gallus)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Gallus gallus)
PTEN [cytosol] (Gallus gallus)
PREX2 binds PTEN and inhibits it (Gallus gallus)
PREX2:PTEN,p-3S,2T-PTEN [cytosol] (Gallus gallus)
PTEN, p-3S,2T-PTEN [cytosol] (Gallus gallus)
PTEN [cytosol] (Gallus gallus)
PTEN, p-3S,2T-PTEN [cytosol] (Gallus gallus)
PTEN [cytosol] (Gallus gallus)
PTEN binds FRK (Gallus gallus)
PTEN [cytosol] (Gallus gallus)
PTEN:p-Y387-FRK [cytosol] (Gallus gallus)
PTEN [cytosol] (Gallus gallus)
TNKS and TNKS2 PARylate PTEN (Gallus gallus)
PTEN [cytosol] (Gallus gallus)
TRIM27 binds PTEN (Gallus gallus)
PTEN [cytosol] (Gallus gallus)
PTEN:TRIM27 [cytosol] (Gallus gallus)
PTEN [cytosol] (Gallus gallus)
TRIM27 polyubiquitinates PTEN (Gallus gallus)
PTEN:TRIM27 [cytosol] (Gallus gallus)
PTEN [cytosol] (Gallus gallus)
USP13 and OTUD3 deubiquitinate PTEN (Gallus gallus)
PTEN [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:F1NT98
Reference Genes
ENSEMBL:ENSGALG00000003634
Participates
as an output of
OTUD3 deubiquitinates PTEN (Gallus gallus)
USP13 and OTUD3 deubiquitinate PTEN (Gallus gallus)
Deubiquitinated PTEN translocates to the cytosol (Gallus gallus)
as a member of
PTEN, p-3S,2T-PTEN [cytosol] (Gallus gallus)
as an input of
MKRN1 polyubiquitinates PTEN (Gallus gallus)
TNKS and TNKS2 PARylate PTEN (Gallus gallus)
PTEN binds FRK (Gallus gallus)
TRIM27 binds PTEN (Gallus gallus)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Gallus gallus)
PTEN undergoes monoubiquitination (Gallus gallus)
as a component of
PTEN:p-Y387-FRK [cytosol] (Gallus gallus)
PTEN:TRIM27 [cytosol] (Gallus gallus)
PTEN:Mg2+ [cytosol] (Gallus gallus)
Other forms of this molecule
K48polyUb-PTEN [cytosol]
PolyUb-PTEN [nucleoplasm]
phospho-p-Y336-PTEN [cytosol]
phospho-PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN [cytosol]
phospho-RibC-E40,E150,D326-PTEN [cytosol]
phospho-p-3S,2T-PTEN [cytosol]
K27polyUb-PTEN [cytosol]
PolyUb-PTEN [cytosol]
K48polyUb-K289-PTEN [cytosol]
MonoUb-K13,K289-PTEN [cytosol]
MonoUb-K13,K289-PTEN [nucleoplasm]
PTEN [nucleoplasm]
Inferred From
PTEN [cytosol]
(Homo sapiens)
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