Reactome | Ig Heavy Chain V Region [extracellular region]

Ig Heavy Chain V Region [extracellular region]

Stable Identifier

R-GGA-197042

Type

Set [DefinedSet]

Species

Gallus gallus

Compartment

extracellular region

Locations in the PathwayBrowser

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Immune System (Gallus gallus)

- Innate Immune System (Gallus gallus)
  - Complement cascade (Gallus gallus)
    - Initial triggering of complement (Gallus gallus)
      - Creation of C4 and C2 activators (Gallus gallus)
        
        Classical antibody-mediated complement activation (Gallus gallus)
        
        Activation of C1r (Gallus gallus)
        
        Antigen:IgG:C1Q:2x Activated C1R:2xC1S [plasma membrane] (Gallus gallus)
        
        Antigen:IgG [plasma membrane] (Gallus gallus)
        
        IgG [extracellular region] (Gallus gallus)
        
        IgG Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
        
        Antigen:IgG:C1Q:2xC1R:2xC1S [plasma membrane] (Gallus gallus)
        
        Antigen:IgG [plasma membrane] (Gallus gallus)
        
        IgG [extracellular region] (Gallus gallus)
        
        IgG Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
        
        Activation of C1s (Gallus gallus)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Gallus gallus)
        
        Antigen:IgG [plasma membrane] (Gallus gallus)
        
        IgG [extracellular region] (Gallus gallus)
        
        IgG Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
        
        Antigen:IgG:C1Q:2x Activated C1R:2xC1S [plasma membrane] (Gallus gallus)
        
        Antigen:IgG [plasma membrane] (Gallus gallus)
        
        IgG [extracellular region] (Gallus gallus)
        
        IgG Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
    - Regulation of Complement cascade (Gallus gallus)
      - C1-Inh binds and inactivates C1r, C1s (Gallus gallus)
        
        Antigen:IgG:C1Q:2xActivated C1R:2xActivated C1S [plasma membrane] (Gallus gallus)
        
        Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane] (Gallus gallus)
        
        Antigen:IgG [plasma membrane] (Gallus gallus)
        
        IgG [extracellular region] (Gallus gallus)
        
        IgG Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
        
        Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 [extracellular region] (Gallus gallus)
        
        Antigen:IgG [plasma membrane] (Gallus gallus)
        
        IgG [extracellular region] (Gallus gallus)
        
        IgG Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
  - Fc epsilon receptor (FCERI) signaling (Gallus gallus)
    - FCERI mediated Ca+2 mobilization (Gallus gallus)
      - Phosphorylation of TEC kinases by p-SYK (Gallus gallus)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Gallus gallus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Gallus gallus)
        
        IgE [extracellular region] (Gallus gallus)
        
        IgE Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
    - FCERI mediated MAPK activation (Gallus gallus)
      - Phosphorylation of SHC by SYK kinase (Gallus gallus)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Gallus gallus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Gallus gallus)
        
        IgE [extracellular region] (Gallus gallus)
        
        IgE Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
      - Phosphorylation of SLP-76 by p-SYK (Gallus gallus)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Gallus gallus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Gallus gallus)
        
        IgE [extracellular region] (Gallus gallus)
        
        IgE Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
    - FCERI mediated NF-kB activation (Gallus gallus)
      - Phosphorylation of PKC-theta (Gallus gallus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Gallus gallus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Gallus gallus)
        
        IgE [extracellular region] (Gallus gallus)
        
        IgE Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
    - IgE binds omalizumab (Gallus gallus)
      - IgE [extracellular region] (Gallus gallus)
        
        IgE Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
      - IgE:omalizumab [extracellular region] (Gallus gallus)
        
        IgE [extracellular region] (Gallus gallus)
        
        IgE Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
    - Recruitment of SYK to p-FCERI gamma subunit (Gallus gallus)
      - Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Gallus gallus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Gallus gallus)
        
        IgE [extracellular region] (Gallus gallus)
        
        IgE Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
      - Clustered p:LYN:p-FCERI:IgE:allergen:SYK [plasma membrane] (Gallus gallus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Gallus gallus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Gallus gallus)
        
        IgE [extracellular region] (Gallus gallus)
        
        IgE Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
    - Role of LAT2/NTAL/LAB on calcium mobilization (Gallus gallus)
      - Phosphorylation of NTAL by p-SYK/Lyn (Gallus gallus)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Gallus gallus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Gallus gallus)
        
        IgE [extracellular region] (Gallus gallus)
        
        IgE Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Gallus gallus)
    - FCGR activation (Gallus gallus)
      - Cross-linking of FCGRIA with IgG-coated Ag (Gallus gallus)
        
        Antigen:IgG [plasma membrane] (Gallus gallus)
        
        IgG [extracellular region] (Gallus gallus)
        
        IgG Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
        
        IgG-Ag:FCGRIA:CD3G homodimer [plasma membrane] (Gallus gallus)
        
        Antigen:IgG [plasma membrane] (Gallus gallus)
        
        IgG [extracellular region] (Gallus gallus)
        
        IgG Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
      - Cross-linking of FCGRIIA with IgG-coated Ag (Gallus gallus)
        
        Antigen:IgG [plasma membrane] (Gallus gallus)
        
        IgG [extracellular region] (Gallus gallus)
        
        IgG Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
        
        IgG-Ag:FCGRIIA [plasma membrane] (Gallus gallus)
        
        Antigen:IgG [plasma membrane] (Gallus gallus)
        
        IgG [extracellular region] (Gallus gallus)
        
        IgG Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
    - Regulation of actin dynamics for phagocytic cup formation (Gallus gallus)
      - Activation of RAC1 by CRKII:DOCK180:ELMO (Gallus gallus)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Gallus gallus)
        
        Antigen:IgG [plasma membrane] (Gallus gallus)
        
        IgG [extracellular region] (Gallus gallus)
        
        IgG Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
      - Activation of RAC1 by VAV (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Gallus gallus)
        
        Antigen:IgG [plasma membrane] (Gallus gallus)
        
        IgG [extracellular region] (Gallus gallus)
        
        IgG Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
      - Phosphorylation of VAV (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Gallus gallus)
        
        Antigen:IgG [plasma membrane] (Gallus gallus)
        
        IgG [extracellular region] (Gallus gallus)
        
        IgG Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Gallus gallus)
        
        Antigen:IgG [plasma membrane] (Gallus gallus)
        
        IgG [extracellular region] (Gallus gallus)
        
        IgG Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Gallus gallus)
        
        Antigen:IgG [plasma membrane] (Gallus gallus)
        
        IgG [extracellular region] (Gallus gallus)
        
        IgG Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
      - Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Gallus gallus)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Gallus gallus)
        
        Antigen:IgG [plasma membrane] (Gallus gallus)
        
        IgG [extracellular region] (Gallus gallus)
        
        IgG Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Gallus gallus)
        
        Antigen:IgG [plasma membrane] (Gallus gallus)
        
        IgG [extracellular region] (Gallus gallus)
        
        IgG Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
      - Recruitment of VAV1 to p-6Y-SYK (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Gallus gallus)
        
        Antigen:IgG [plasma membrane] (Gallus gallus)
        
        IgG [extracellular region] (Gallus gallus)
        
        IgG Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Gallus gallus)
        
        Antigen:IgG [plasma membrane] (Gallus gallus)
        
        IgG [extracellular region] (Gallus gallus)
        
        IgG Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
    - Role of phospholipids in phagocytosis (Gallus gallus)
      - PI3K binds to p-6Y-SYK (Gallus gallus)
        
        PI3K:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Gallus gallus)
        
        Antigen:IgG [plasma membrane] (Gallus gallus)
        
        IgG [extracellular region] (Gallus gallus)
        
        IgG Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Gallus gallus)
        
        Antigen:IgG [plasma membrane] (Gallus gallus)
        
        IgG [extracellular region] (Gallus gallus)
        
        IgG Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
      - PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
        
        PI3K:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Gallus gallus)
        
        Antigen:IgG [plasma membrane] (Gallus gallus)
        
        IgG [extracellular region] (Gallus gallus)
        
        IgG Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
      - Phosphorylation and activation of PLCG (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Gallus gallus)
        
        Antigen:IgG [plasma membrane] (Gallus gallus)
        
        IgG [extracellular region] (Gallus gallus)
        
        IgG Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Gallus gallus)
        
        Antigen:IgG [plasma membrane] (Gallus gallus)
        
        IgG [extracellular region] (Gallus gallus)
        
        IgG Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
      - Recruitment of PLCgamma to membrane (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Gallus gallus)
        
        Antigen:IgG [plasma membrane] (Gallus gallus)
        
        IgG [extracellular region] (Gallus gallus)
        
        IgG Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Gallus gallus)
        
        Antigen:IgG [plasma membrane] (Gallus gallus)
        
        IgG [extracellular region] (Gallus gallus)
        
        IgG Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
      - Release of PLCG from FCGR (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Gallus gallus)
        
        Antigen:IgG [plasma membrane] (Gallus gallus)
        
        IgG [extracellular region] (Gallus gallus)
        
        IgG Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Gallus gallus)
        
        Antigen:IgG [plasma membrane] (Gallus gallus)
        
        IgG [extracellular region] (Gallus gallus)
        
        IgG Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)

Vesicle-mediated transport (Gallus gallus)

- Binding and Uptake of Ligands by Scavenger Receptors (Gallus gallus)
  - Scavenging of heme from plasma (Gallus gallus)
    - Alpha-1-Microglobulin is cleaved (Gallus gallus)
      - 2xIgA:JCHAIN [extracellular region] (Gallus gallus)
        
        IgA [extracellular region] (Gallus gallus)
        
        IgA Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)
      - IgA:Alpha-1-Microglobulin [extracellular region] (Gallus gallus)
        
        2xIgA:JCHAIN [extracellular region] (Gallus gallus)
        
        IgA [extracellular region] (Gallus gallus)
        
        IgA Heavy Chain [extracellular region] (Gallus gallus)
        
        Ig Heavy Chain V Region [extracellular region] (Gallus gallus)

Participants

members

Participates

as a component of

Inferred From

Ig Heavy Chain V Region [extracellular region] (Homo sapiens)

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