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What is Reactome ?
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Klotho bound to FGF23 [plasma membrane]
Stable Identifier
R-GGA-190208
Type
Complex
Species
Gallus gallus
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Gallus gallus)
Intracellular signaling by second messengers (Gallus gallus)
PIP3 activates AKT signaling (Gallus gallus)
Negative regulation of the PI3K/AKT network (Gallus gallus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
Activator:PI3K [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Gallus gallus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
Activator:PI3K [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Gallus gallus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
MAPK family signaling cascades (Gallus gallus)
MAPK1/MAPK3 signaling (Gallus gallus)
RAF/MAP kinase cascade (Gallus gallus)
RAS GEFs promote RAS nucleotide exchange (Gallus gallus)
RAS GEFs [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS3 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-SHC1 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by FGFR (Gallus gallus)
Signaling by FGFR1 (Gallus gallus)
Downstream signaling of activated FGFR1 (Gallus gallus)
Activated FGFR1 binds FLRT1,2,3 (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:FLRT [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
FRS-mediated FGFR1 signaling (Gallus gallus)
Activated FGFR1 binds FRS2 (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1 binds FRS3 (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:FRS3 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1 phosphorylates FRS2 (Gallus gallus)
Activated FGFR1:FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1 phosphorylates FRS3 (Gallus gallus)
Activated FGFR1:FRS3 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS3 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS bind to PPTN11 (Gallus gallus)
Activated FGFR1:p-FRS [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS3 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS3 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS binds GRB2:SOS1 (Gallus gallus)
Activated FGFR1:p-FRS [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS3 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS3 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS phosphorylates PPTN11 (Gallus gallus)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS3 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS3 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS3 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Gallus gallus)
Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS3 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
PI-3K cascade:FGFR1 (Gallus gallus)
Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Gallus gallus)
Activated FGFR1:p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Gallus gallus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Gallus gallus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Gallus gallus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Phospholipase C-mediated cascade: FGFR1 (Gallus gallus)
Activated FGFR1 binds PLCG1 (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
activated FGFR1:PLCG1 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1 phosphorylates PLCG1 (Gallus gallus)
activated FGFR1:PLCG1 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
activated FGFR1:p-4Y-PLCG1 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
p-4Y-PLCG1 dissociates from activated FGFR1 (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
activated FGFR1:p-4Y-PLCG1 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
SHC-mediated cascade:FGFR1 (Gallus gallus)
Activated FGFR1 binds SHC1 (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:SHC1 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1 phosphorylates SHC1 (Gallus gallus)
Activated FGFR1:SHC1 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-SHC1 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Gallus gallus)
Activated FGFR1:p-SHC1 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-SHC1 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-SHC1 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
FGFR1 ligand binding and activation (Gallus gallus)
FGFR1c and Klotho ligand binding and activation (Gallus gallus)
Autocatalytic phosphorylation of Klotho-bound FGFR1c (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
FGF23 bound to Klotho and FGFR1c [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
FGFR1c binds to Klotho-bound FGF23 (Gallus gallus)
FGF23 bound to Klotho and FGFR1c [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Negative regulation of FGFR1 signaling (Gallus gallus)
Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Gallus gallus)
Activated FGFR1:FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-8T-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
CBL ubiquitinates FRS2 and FGFR1 (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1 [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Signaling by Insulin receptor (Gallus gallus)
Insulin receptor signalling cascade (Gallus gallus)
IRS-mediated signalling (Gallus gallus)
PI3K Cascade (Gallus gallus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Gallus gallus)
PI3K-containing complexes [cytosol] (Gallus gallus)
Activated FGFR bound to PI3K [cytosol] (Gallus gallus)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Gallus gallus)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
Activated FGFR:p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Gallus gallus)
IGF1R signaling cascade (Gallus gallus)
IRS-related events triggered by IGF1R (Gallus gallus)
IRS-mediated signalling (Gallus gallus)
PI3K Cascade (Gallus gallus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Gallus gallus)
PI3K-containing complexes [cytosol] (Gallus gallus)
Activated FGFR bound to PI3K [cytosol] (Gallus gallus)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Gallus gallus)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
Activated FGFR:p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Klotho bound to FGF23 [plasma membrane] (Gallus gallus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
FGF23 [extracellular region]
(Gallus gallus)
Klotho homodimer [plasma membrane]
(Gallus gallus)
Participates
as an input of
FGFR1c binds to Klotho-bound FGF23 (Gallus gallus)
as a component of
FGF23 bound to Klotho and FGFR1c [plasma membrane] (Gallus gallus)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Gallus gallus)
Inferred From
Klotho bound to FGF23 [plasma membrane]
(Homo sapiens)
© 2024
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