Reactome | CD88 [plasma membrane]

CD88 [plasma membrane]

Stable Identifier

R-GGA-179789

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

plasma membrane

Synonyms

CD80, A0A8V0XUH0

Locations in the PathwayBrowser

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Immune System (Gallus gallus)

- Adaptive Immune System (Gallus gallus)
  - Regulation of T cell activation by CD28 family (Gallus gallus)
    - Co-inhibition by CTLA4 (Gallus gallus)
      - CTLA-4 binds B7-1/B7-2 (Gallus gallus)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Gallus gallus)
        
        CD80 dimer [plasma membrane] (Gallus gallus)
        
        CD88 [plasma membrane] (Gallus gallus)
        
        PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Gallus gallus)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Gallus gallus)
        
        CD80 dimer [plasma membrane] (Gallus gallus)
        
        CD88 [plasma membrane] (Gallus gallus)
      - SHP2 phosphatase binds CTLA-4 (Gallus gallus)
        
        p-Y201,Y218-CTLA-4 dimer:SFKs [plasma membrane] (Gallus gallus)
        
        p-Y201,Y218-CTLA4 dimer:B7-1/B7-2 [plasma membrane] (Gallus gallus)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Gallus gallus)
        
        CD80 dimer [plasma membrane] (Gallus gallus)
        
        CD88 [plasma membrane] (Gallus gallus)
        
        pCTLA-4:Src kinases:SHP2 [plasma membrane] (Gallus gallus)
        
        p-Y201,Y218-CTLA-4 dimer:SFKs [plasma membrane] (Gallus gallus)
        
        p-Y201,Y218-CTLA4 dimer:B7-1/B7-2 [plasma membrane] (Gallus gallus)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Gallus gallus)
        
        CD80 dimer [plasma membrane] (Gallus gallus)
        
        CD88 [plasma membrane] (Gallus gallus)
    - Co-stimulation by CD28 (Gallus gallus)
      - CD28 dependent PI3K/Akt signaling (Gallus gallus)
        
        CD28 bound PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
        
        CD28:PI3K [plasma membrane] (Gallus gallus)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Gallus gallus)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Gallus gallus)
        
        CD80 dimer [plasma membrane] (Gallus gallus)
        
        CD88 [plasma membrane] (Gallus gallus)
        
        PI3K binds CD28 (Gallus gallus)
        
        CD28:PI3K [plasma membrane] (Gallus gallus)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Gallus gallus)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Gallus gallus)
        
        CD80 dimer [plasma membrane] (Gallus gallus)
        
        CD88 [plasma membrane] (Gallus gallus)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Gallus gallus)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Gallus gallus)
        
        CD80 dimer [plasma membrane] (Gallus gallus)
        
        CD88 [plasma membrane] (Gallus gallus)
      - CD28 dependent Vav1 pathway (Gallus gallus)
        
        Activation of Cdc42 by pVav1 (Gallus gallus)
        
        p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Gallus gallus)
        
        CD28:Grb2 [plasma membrane] (Gallus gallus)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Gallus gallus)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Gallus gallus)
        
        CD80 dimer [plasma membrane] (Gallus gallus)
        
        CD88 [plasma membrane] (Gallus gallus)
        
        Activation of Rac1 by pVav1 (Gallus gallus)
        
        p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Gallus gallus)
        
        CD28:Grb2 [plasma membrane] (Gallus gallus)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Gallus gallus)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Gallus gallus)
        
        CD80 dimer [plasma membrane] (Gallus gallus)
        
        CD88 [plasma membrane] (Gallus gallus)
        
        Activation of Vav1 (Gallus gallus)
        
        VAV1:PIP3:CD28:GRB2 [plasma membrane] (Gallus gallus)
        
        CD28:Grb2 [plasma membrane] (Gallus gallus)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Gallus gallus)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Gallus gallus)
        
        CD80 dimer [plasma membrane] (Gallus gallus)
        
        CD88 [plasma membrane] (Gallus gallus)
        
        p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Gallus gallus)
        
        CD28:Grb2 [plasma membrane] (Gallus gallus)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Gallus gallus)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Gallus gallus)
        
        CD80 dimer [plasma membrane] (Gallus gallus)
        
        CD88 [plasma membrane] (Gallus gallus)
        
        Grb2 binds CD28 (Gallus gallus)
        
        CD28:Grb2 [plasma membrane] (Gallus gallus)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Gallus gallus)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Gallus gallus)
        
        CD80 dimer [plasma membrane] (Gallus gallus)
        
        CD88 [plasma membrane] (Gallus gallus)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Gallus gallus)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Gallus gallus)
        
        CD80 dimer [plasma membrane] (Gallus gallus)
        
        CD88 [plasma membrane] (Gallus gallus)
        
        Translocation of Vav1 to CD28 (Gallus gallus)
        
        CD28:Grb2 [plasma membrane] (Gallus gallus)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Gallus gallus)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Gallus gallus)
        
        CD80 dimer [plasma membrane] (Gallus gallus)
        
        CD88 [plasma membrane] (Gallus gallus)
        
        VAV1:PIP3:CD28:GRB2 [plasma membrane] (Gallus gallus)
        
        CD28:Grb2 [plasma membrane] (Gallus gallus)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Gallus gallus)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Gallus gallus)
        
        CD80 dimer [plasma membrane] (Gallus gallus)
        
        CD88 [plasma membrane] (Gallus gallus)
      - CD28 homodimer binds B7-1 homodimer (Gallus gallus)
        
        CD28:B7-1 [plasma membrane] (Gallus gallus)
        
        CD80 dimer [plasma membrane] (Gallus gallus)
        
        CD88 [plasma membrane] (Gallus gallus)
        
        CD80 dimer [plasma membrane] (Gallus gallus)
        
        CD88 [plasma membrane] (Gallus gallus)
        
        PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Gallus gallus)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Gallus gallus)
        
        CD80 dimer [plasma membrane] (Gallus gallus)
        
        CD88 [plasma membrane] (Gallus gallus)
      - CD28 homodimer binds B7-2 monomer (Gallus gallus)
        
        PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Gallus gallus)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Gallus gallus)
        
        CD80 dimer [plasma membrane] (Gallus gallus)
        
        CD88 [plasma membrane] (Gallus gallus)
      - Gads binds CD28 (Gallus gallus)
        
        CD28:GRAP2 [plasma membrane] (Gallus gallus)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Gallus gallus)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Gallus gallus)
        
        CD80 dimer [plasma membrane] (Gallus gallus)
        
        CD88 [plasma membrane] (Gallus gallus)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Gallus gallus)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Gallus gallus)
        
        CD80 dimer [plasma membrane] (Gallus gallus)
        
        CD88 [plasma membrane] (Gallus gallus)
      - Phosphorylation of CD28 (Gallus gallus)
        
        CD28:B7-1,B7-2 [plasma membrane] (Gallus gallus)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Gallus gallus)
        
        CD80 dimer [plasma membrane] (Gallus gallus)
        
        CD88 [plasma membrane] (Gallus gallus)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Gallus gallus)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Gallus gallus)
        
        CD80 dimer [plasma membrane] (Gallus gallus)
        
        CD88 [plasma membrane] (Gallus gallus)

Signal Transduction (Gallus gallus)

- Intracellular signaling by second messengers (Gallus gallus)
  - PIP3 activates AKT signaling (Gallus gallus)
    - Negative regulation of the PI3K/AKT network (Gallus gallus)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Gallus gallus)
        
        PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
        
        Activator:PI3K [plasma membrane] (Gallus gallus)
        
        CD28:PI3K [plasma membrane] (Gallus gallus)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Gallus gallus)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Gallus gallus)
        
        CD80 dimer [plasma membrane] (Gallus gallus)
        
        CD88 [plasma membrane] (Gallus gallus)
    - PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
      - Activator:PI3K [plasma membrane] (Gallus gallus)
        
        CD28:PI3K [plasma membrane] (Gallus gallus)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Gallus gallus)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Gallus gallus)
        
        CD80 dimer [plasma membrane] (Gallus gallus)
        
        CD88 [plasma membrane] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A8V0XUH0

Gene Names

CD88

Reference Genes

BioGPS Gene:768950 CD88

CTD Gene:768950 CD88

ENSEMBL:ENSGALG00010007894.1

KEGG:gga:768950 CD88

Monarch:768950 CD88

NCBI Gene:768950 CD88

UCSC:A0A8V0XUH0 CD88

Reference Transcript

RefSeq:NM_001079739.2 CD88

Other Identifiers

768950

GO:0002376

GO:0005886

GO:0006955

GO:0007166

GO:0009897

GO:0016020

GO:0031295

GO:0042102

GO:0042130

GO:0071222

GT_A_87_P132863

GT_A_87_P216588

GgaAffx.9855.1.S1_at

Participates

as a component of

CD80 dimer [plasma membrane] (Gallus gallus)

Inferred From

CD80 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001073207.2

ENSEMBL

ENSGALP00010010334, ENSGALT00010018784, ENSGALG00010007894

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