Reactome | ANAPC4 [cytosol]

ANAPC4 [cytosol]

Stable Identifier

R-GGA-174168

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

ANAPC4, A0A8V0Y778

Locations in the PathwayBrowser

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Cell Cycle (Gallus gallus)

- Cell Cycle Checkpoints (Gallus gallus)
  - Mitotic Spindle Checkpoint (Gallus gallus)
    - Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Gallus gallus)
      - Inactivation of APC/C via direct inhibition of the APC/C complex (Gallus gallus)
        
        Binding of the MCC complex to the APC/C complex (Gallus gallus)
        
        MCC:APC/C complex [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
- Cell Cycle, Mitotic (Gallus gallus)
  - M Phase (Gallus gallus)
    - Mitotic Metaphase and Anaphase (Gallus gallus)
      - Mitotic Anaphase (Gallus gallus)
        
        Separation of Sister Chromatids (Gallus gallus)
        
        Association of Securin with Cdc20:APC/C complex (Gallus gallus)
        
        CDC20:p-APC/C [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Gallus gallus)
        
        CDC20:p-APC/C [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        Degradation of multiubiquitinated Securin (Gallus gallus)
        
        CDC20:p-APC/C [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Gallus gallus)
        
        CDC20:p-APC/C [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Gallus gallus)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Gallus gallus)
        
        CDC20:p-APC/C [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Gallus gallus)
        
        CDC20:p-APC/C [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
  - Regulation of mitotic cell cycle (Gallus gallus)
    - APC/C-mediated degradation of cell cycle proteins (Gallus gallus)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Gallus gallus)
        
        Association of cell cycle proteins with the APC/C:Cdh1 complex (Gallus gallus)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Gallus gallus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        Degradation of multiubiquitinated cell cycle proteins (Gallus gallus)
        
        multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Gallus gallus)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Gallus gallus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Gallus gallus)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Gallus gallus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Gallus gallus)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Gallus gallus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Gallus gallus)
        
        APC/C:Cdc20 mediated degradation of mitotic proteins (Gallus gallus)
        
        APC/C:Cdc20 mediated degradation of Cyclin B (Gallus gallus)
        
        Degradation of multiubiquitinated Cyclin B (Gallus gallus)
        
        CDC20:p-APC/C [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Gallus gallus)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Gallus gallus)
        
        CDC20:p-APC/C [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Gallus gallus)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Gallus gallus)
        
        CDC20:p-APC/C [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Gallus gallus)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Gallus gallus)
        
        CDC20:p-APC/C [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        APC/C:Cdc20 mediated degradation of Securin (Gallus gallus)
        
        Association of Securin with Cdc20:APC/C complex (Gallus gallus)
        
        CDC20:p-APC/C [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Gallus gallus)
        
        CDC20:p-APC/C [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        Degradation of multiubiquitinated Securin (Gallus gallus)
        
        CDC20:p-APC/C [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Gallus gallus)
        
        CDC20:p-APC/C [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Gallus gallus)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Gallus gallus)
        
        CDC20:p-APC/C [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Gallus gallus)
        
        CDC20:p-APC/C [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Gallus gallus)
        
        APC-Cdc20 mediated degradation of Nek2A (Gallus gallus)
        
        Association of Nek2A with MCC:APC/C (Gallus gallus)
        
        MCC:APC/C complex [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        Nek2A:MCC:APC/C complex [cytosol] (Gallus gallus)
        
        MCC:APC/C complex [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        Degradation of multiubiquitinated Nek2A (Gallus gallus)
        
        MCC:APC/C complex [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        Multiubiquitinated Nek2A [cytosol] (Gallus gallus)
        
        Nek2A:MCC:APC/C complex [cytosol] (Gallus gallus)
        
        MCC:APC/C complex [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        Multiubiquitination of Nek2A (Gallus gallus)
        
        Multiubiquitinated Nek2A [cytosol] (Gallus gallus)
        
        Nek2A:MCC:APC/C complex [cytosol] (Gallus gallus)
        
        MCC:APC/C complex [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        Nek2A:MCC:APC/C complex [cytosol] (Gallus gallus)
        
        MCC:APC/C complex [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Gallus gallus)
        
        Association of Cyclin A with the APC/C (Gallus gallus)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Gallus gallus)
        
        MCC:APC/C complex [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        MCC:APC/C complex [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        Degradation multiubiquitinated Cyclin A (Gallus gallus)
        
        MCC:APC/C complex [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Gallus gallus)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Gallus gallus)
        
        MCC:APC/C complex [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Gallus gallus)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Gallus gallus)
        
        MCC:APC/C complex [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        MCC:APC/C complex [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Gallus gallus)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Gallus gallus)
        
        MCC:APC/C complex [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Gallus gallus)
        
        CDC20:p-APC/C [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        MCC:APC/C complex [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
      - Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Gallus gallus)
        
        Association of Cdh1 with the APC/C (Gallus gallus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        Dissociation of Cdc20 from APC/C complex (Gallus gallus)
        
        CDC20:p-APC/C [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
      - Regulation of APC/C activators between G1/S and early anaphase (Gallus gallus)
        
        Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Gallus gallus)
        
        Inactivation of APC/C via direct inhibition of the APC/C complex (Gallus gallus)
        
        Binding of the MCC complex to the APC/C complex (Gallus gallus)
        
        MCC:APC/C complex [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
  - S Phase (Gallus gallus)
    - Synthesis of DNA (Gallus gallus)
      - Switching of origins to a post-replicative state (Gallus gallus)
        
        CDK-mediated phosphorylation and removal of Cdc6 (Gallus gallus)
        
        Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Gallus gallus)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Gallus gallus)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)

Immune System (Gallus gallus)

- Adaptive Immune System (Gallus gallus)
  - Class I MHC mediated antigen processing & presentation (Gallus gallus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Gallus gallus)
      - Interaction of E3 with substrate and E2-Ub complex (Gallus gallus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        APC/C E3 ligase complex [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        APC/C E3 ligase complex [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
      - Polyubiquitination of substrate (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        APC/C E3 ligase complex [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        APC/C E3 ligase complex [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        E3:Ub:substrate [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        APC/C E3 ligase complex [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
      - Release of E3 from polyubiquitinated substrate (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        APC/C E3 ligase complex [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        APC/C E3 ligase complex [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
      - Transfer of Ub from E2 to substrate and release of E2 (Gallus gallus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        APC/C E3 ligase complex [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        APC/C E3 ligase complex [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)
        
        E3:Ub:substrate [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        APC/C E3 ligase complex [cytosol] (Gallus gallus)
        
        ANAPC4 [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A8V0Y778

Gene Names

ANAPC4

Reference Genes

BioGPS Gene:422805 ANAPC4

ENSEMBL:ENSGALG00010010933.1

Monarch:422805 ANAPC4

NCBI Gene:422805 ANAPC4

UCSC:A0A8V0Y778 ANAPC4

Reference Transcript

RefSeq:XM_040699297.1 ANAPC4

Other Identifiers

422805

GO:0005515

GO:0005634

GO:0005680

GO:0019903

GO:0030071

GO:0030163

GO:0031145

GO:0034399

GO:0051301

GO:0070936

GO:0070979

GO:0141198

GT_A_87_P036337

GT_A_87_P155368

Gga.17940.1.S1_at

GgaAffx.12645.1.S1_at

Participates

as a component of

Other forms of this molecule

ANAPC4 [nucleoplasm]

Inferred From

ANAPC4 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_040555231.1

ENSEMBL

ENSGALT00010026186, ENSGALG00010010933, ENSGALP00010014810

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