Reactome | MTOR [cytosol]

MTOR

Stable Identifier

R-GGA-165662

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

A0A1D5P858

Locations in the PathwayBrowser

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Cellular responses to external stimuli (Gallus gallus)

- Macroautophagy (Gallus gallus)
  - Active mTORC1 binds the ULK1 complex (Gallus gallus)
    - Active mTORC1 complex [lysosomal membrane] (Gallus gallus)
      - mTORC1:Ragulator:Rag dimers:SLC38A9 [lysosomal membrane] (Gallus gallus)
        
        mTORC1 [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
    - mTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Gallus gallus)
      - Active mTORC1 complex [lysosomal membrane] (Gallus gallus)
        
        mTORC1:Ragulator:Rag dimers:SLC38A9 [lysosomal membrane] (Gallus gallus)
        
        mTORC1 [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
  - Active mTORC1 phosphorylates ULK1 (Gallus gallus)
    - Homologues of MTOR [cytosol] (Gallus gallus)
      - MTOR [cytosol] (Gallus gallus)
    - mTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Gallus gallus)
      - Active mTORC1 complex [lysosomal membrane] (Gallus gallus)
        
        mTORC1:Ragulator:Rag dimers:SLC38A9 [lysosomal membrane] (Gallus gallus)
        
        mTORC1 [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
    - mTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Gallus gallus)
      - Active mTORC1 complex [lysosomal membrane] (Gallus gallus)
        
        mTORC1:Ragulator:Rag dimers:SLC38A9 [lysosomal membrane] (Gallus gallus)
        
        mTORC1 [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
  - Rheb in the mTORC1 complex hydrolyses GTP (Gallus gallus)
    - Active mTORC1 complex [lysosomal membrane] (Gallus gallus)
      - mTORC1:Ragulator:Rag dimers:SLC38A9 [lysosomal membrane] (Gallus gallus)
        
        mTORC1 [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
    - mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Gallus gallus)
      - mTORC1:Ragulator:Rag dimers:SLC38A9 [lysosomal membrane] (Gallus gallus)
        
        mTORC1 [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
  - mTORC1 dissociates from ULK complex (Gallus gallus)
    - mTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Gallus gallus)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Gallus gallus)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Gallus gallus)
        
        mTORC1 with p-S722,S792-RPTOR [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
    - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Gallus gallus)
      - mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Gallus gallus)
        
        mTORC1 with p-S722,S792-RPTOR [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
  - p-AMPK:AMP phosphorylates Raptor in the mTORC1 complex (Gallus gallus)
    - mTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Gallus gallus)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Gallus gallus)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Gallus gallus)
        
        mTORC1 with p-S722,S792-RPTOR [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
    - mTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Gallus gallus)
      - Active mTORC1 complex [lysosomal membrane] (Gallus gallus)
        
        mTORC1:Ragulator:Rag dimers:SLC38A9 [lysosomal membrane] (Gallus gallus)
        
        mTORC1 [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)

Gene expression (Transcription) (Gallus gallus)

- RNA Polymerase II Transcription (Gallus gallus)
  - Generic Transcription Pathway (Gallus gallus)
    - Transcriptional Regulation by TP53 (Gallus gallus)
      - Regulation of TP53 Activity (Gallus gallus)
        
        Regulation of TP53 Expression and Degradation (Gallus gallus)
        
        Regulation of TP53 Degradation (Gallus gallus)
        
        TORC2 complex phosphorylates SGK1 (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
        
        TORC2 complex [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
      - TP53 Regulates Metabolic Genes (Gallus gallus)
        
        RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Gallus gallus)
        
        Active mTORC1 complex [lysosomal membrane] (Gallus gallus)
        
        mTORC1:Ragulator:Rag dimers:SLC38A9 [lysosomal membrane] (Gallus gallus)
        
        mTORC1 [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
        
        mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Gallus gallus)
        
        mTORC1:Ragulator:Rag dimers:SLC38A9 [lysosomal membrane] (Gallus gallus)
        
        mTORC1 [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)

Immune System (Gallus gallus)

- Adaptive Immune System (Gallus gallus)
  - Costimulation by the CD28 family (Gallus gallus)
    - CD28 co-stimulation (Gallus gallus)
      - CD28 dependent PI3K/Akt signaling (Gallus gallus)
        
        TORC2 (mTOR) phosphorylates AKT at S473 (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
        
        TORC2 complex [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)

Signal Transduction (Gallus gallus)

- Intracellular signaling by second messengers (Gallus gallus)
  - PIP3 activates AKT signaling (Gallus gallus)
    - PTEN Regulation (Gallus gallus)
      - Regulation of PTEN gene transcription (Gallus gallus)
        
        MAF1 translocates to the nucleus (Gallus gallus)
        
        Active mTORC1 complex [lysosomal membrane] (Gallus gallus)
        
        mTORC1:Ragulator:Rag dimers:SLC38A9 [lysosomal membrane] (Gallus gallus)
        
        mTORC1 [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
        
        mTORC1 phosphorylates MAF1 (Gallus gallus)
        
        Active mTORC1 complex [lysosomal membrane] (Gallus gallus)
        
        mTORC1:Ragulator:Rag dimers:SLC38A9 [lysosomal membrane] (Gallus gallus)
        
        mTORC1 [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
    - TORC2 (mTOR) phosphorylates AKT at S473 (Gallus gallus)
      - Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
      - TORC2 complex [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
- Signaling by Receptor Tyrosine Kinases (Gallus gallus)
  - Signaling by VEGF (Gallus gallus)
    - VEGFA-VEGFR2 Pathway (Gallus gallus)
      - VEGFR2 mediated vascular permeability (Gallus gallus)
        
        TORC2 (mTOR) phosphorylates AKT at S473 (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
        
        TORC2 complex [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
- mTOR signalling (Gallus gallus)
  - Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Gallus gallus)
    - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Gallus gallus)
      - Active mTORC1 complex [lysosomal membrane] (Gallus gallus)
        
        mTORC1:Ragulator:Rag dimers:SLC38A9 [lysosomal membrane] (Gallus gallus)
        
        mTORC1 [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
    - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Gallus gallus)
      - Active mTORC1 complex [lysosomal membrane] (Gallus gallus)
        
        mTORC1:Ragulator:Rag dimers:SLC38A9 [lysosomal membrane] (Gallus gallus)
        
        mTORC1 [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
  - Energy dependent regulation of mTOR by LKB1-AMPK (Gallus gallus)
    - AMPK phosphorylates Raptor in the mTORC1 complex (Gallus gallus)
      - Active mTORC1 complex [lysosomal membrane] (Gallus gallus)
        
        mTORC1:Ragulator:Rag dimers:SLC38A9 [lysosomal membrane] (Gallus gallus)
        
        mTORC1 [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Gallus gallus)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Gallus gallus)
        
        mTORC1 with p-S722,S792-RPTOR [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
    - RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Gallus gallus)
      - Active mTORC1 complex [lysosomal membrane] (Gallus gallus)
        
        mTORC1:Ragulator:Rag dimers:SLC38A9 [lysosomal membrane] (Gallus gallus)
        
        mTORC1 [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
      - mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Gallus gallus)
        
        mTORC1:Ragulator:Rag dimers:SLC38A9 [lysosomal membrane] (Gallus gallus)
        
        mTORC1 [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
  - Formation of active mTORC1 complex (Gallus gallus)
    - Active mTORC1 complex [lysosomal membrane] (Gallus gallus)
      - mTORC1:Ragulator:Rag dimers:SLC38A9 [lysosomal membrane] (Gallus gallus)
        
        mTORC1 [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
    - mTORC1:Ragulator:Rag dimers:SLC38A9 [lysosomal membrane] (Gallus gallus)
      - mTORC1 [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
  - Phosphorylated AKT1S1:mTORC1 binds YWHAB (Gallus gallus)
    - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Gallus gallus)
      - Active mTORC1 complex [lysosomal membrane] (Gallus gallus)
        
        mTORC1:Ragulator:Rag dimers:SLC38A9 [lysosomal membrane] (Gallus gallus)
        
        mTORC1 [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
    - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Gallus gallus)
      - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Gallus gallus)
        
        Active mTORC1 complex [lysosomal membrane] (Gallus gallus)
        
        mTORC1:Ragulator:Rag dimers:SLC38A9 [lysosomal membrane] (Gallus gallus)
        
        mTORC1 [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
  - Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Gallus gallus)
    - mTORC1 [cytosol] (Gallus gallus)
      - Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
    - mTORC1:Ragulator:Rag dimers:SLC38A9 [lysosomal membrane] (Gallus gallus)
      - mTORC1 [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
  - mTORC1 phosphorylates AKT1S1 (Gallus gallus)
    - Homologues of MTOR [cytosol] (Gallus gallus)
      - MTOR [cytosol] (Gallus gallus)
    - mTORC1:RHEB:GTP:p-S183,T246-AKT1S1:YWHAB [lysosomal membrane] (Gallus gallus)
      - mTORC1:RHEB:GTP:p-S183,T246-AKT1S1 [lysosomal membrane] (Gallus gallus)
        
        Active mTORC1 complex [lysosomal membrane] (Gallus gallus)
        
        mTORC1:Ragulator:Rag dimers:SLC38A9 [lysosomal membrane] (Gallus gallus)
        
        mTORC1 [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
    - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Gallus gallus)
      - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Gallus gallus)
        
        Active mTORC1 complex [lysosomal membrane] (Gallus gallus)
        
        mTORC1:Ragulator:Rag dimers:SLC38A9 [lysosomal membrane] (Gallus gallus)
        
        mTORC1 [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
  - mTORC1-mediated signalling (Gallus gallus)
    - Phosphorylation of 4E-BP1 by activated mTORC1 (Gallus gallus)
      - Active mTORC1 complex [lysosomal membrane] (Gallus gallus)
        
        mTORC1:Ragulator:Rag dimers:SLC38A9 [lysosomal membrane] (Gallus gallus)
        
        mTORC1 [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
      - Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
      - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Gallus gallus)
        
        Active mTORC1 complex [lysosomal membrane] (Gallus gallus)
        
        mTORC1:Ragulator:Rag dimers:SLC38A9 [lysosomal membrane] (Gallus gallus)
        
        mTORC1 [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
      - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Gallus gallus)
        
        mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Gallus gallus)
        
        Active mTORC1 complex [lysosomal membrane] (Gallus gallus)
        
        mTORC1:Ragulator:Rag dimers:SLC38A9 [lysosomal membrane] (Gallus gallus)
        
        mTORC1 [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
    - mTORC1 phosphorylation of RPS6KB1 (S6K) (Gallus gallus)
      - Active mTORC1 complex [lysosomal membrane] (Gallus gallus)
        
        mTORC1:Ragulator:Rag dimers:SLC38A9 [lysosomal membrane] (Gallus gallus)
        
        mTORC1 [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
      - Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Gallus gallus)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Gallus gallus)
        
        mTORC1 with p-S722,S792-RPTOR [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)
      - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Gallus gallus)
        
        mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Gallus gallus)
        
        Active mTORC1 complex [lysosomal membrane] (Gallus gallus)
        
        mTORC1:Ragulator:Rag dimers:SLC38A9 [lysosomal membrane] (Gallus gallus)
        
        mTORC1 [cytosol] (Gallus gallus)
        
        Homologues of MTOR [cytosol] (Gallus gallus)
        
        MTOR [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A1D5P858

Reference Genes

ENSEMBL:ENSGALG00000003339

Other Identifiers

419455

AADN04000178

ENSGALG00000003339

ENSGALP00000048903

ENSGALT00000060068

EntrezGene:419455

GgaAffx.1955.1.S1_at

GgaAffx.2006.1.S1_at

GgaAffx.2082.1.S1_at

GO:0000003

GO:0000166

GO:0001030

GO:0001031

GO:0001032

GO:0001156

GO:0001558

GO:0001932

GO:0001934

GO:0002376

GO:0003007

GO:0003013

GO:0003179

GO:0003674

GO:0003677

GO:0004672

GO:0004674

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005764

GO:0005773

GO:0005829

GO:0006091

GO:0006112

GO:0006207

GO:0006412

GO:0006461

GO:0006464

GO:0006468

GO:0006605

GO:0006629

GO:0006810

GO:0006913

GO:0006914

GO:0006950

GO:0007010

GO:0007165

GO:0007281

GO:0007584

GO:0008134

GO:0008150

GO:0008361

GO:0009056

GO:0009058

GO:0009267

GO:0009791

GO:0010507

GO:0010592

GO:0010628

GO:0010718

GO:0010831

GO:0012505

GO:0016020

GO:0016242

GO:0016301

GO:0016310

GO:0016605

GO:0016740

GO:0018105

GO:0018107

GO:0022607

GO:0030030

GO:0030154

GO:0030425

GO:0030838

GO:0031529

GO:0031641

GO:0031669

GO:0031929

GO:0031931

GO:0031932

GO:0032868

GO:0032956

GO:0034198

GO:0034641

GO:0035264

GO:0038202

GO:0040007

GO:0040011

GO:0042802

GO:0043022

GO:0043087

GO:0043167

GO:0043200

GO:0043226

GO:0043234

GO:0044281

GO:0044877

GO:0045670

GO:0045727

GO:0045792

GO:0045859

GO:0045945

GO:0046777

GO:0046889

GO:0048714

GO:0048738

GO:0048856

GO:0048870

GO:0050731

GO:0050882

GO:0051219

GO:0051496

GO:0051534

GO:0051549

GO:0051896

GO:0055006

GO:0055013

GO:0060048

GO:0065003

GO:0071230

GO:0071233

GO:0071456

GO:0090559

GO:1901838

GO:1903691

GO:1990253

GT_A_87_P065656

HGNC:3942

IPR000403

IPR003151

IPR003152

IPR009076

IPR011009

IPR011989

IPR011990

IPR014009

IPR016024

IPR018936

IPR024585

IPR026683

MTOR

MTOR-201

PF00454

PF02259

PF02260

PF08771

PF11865

SM00146

SM01343

SM01345

SM01346

UPI00085AD606

Participant Of

hasMember

Homologues of MTOR [cytosol]

Other forms of this molecule

MTOR [nucleoplasm]

Inferred From

MTOR [cytosol] (Homo sapiens)