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sSCF dimer [extracellular region]
Stable Identifier
R-GGA-1433307
Type
Complex
Species
Gallus gallus
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Developmental Biology (Gallus gallus)
MITF-M-regulated melanocyte development (Gallus gallus)
Transcriptional and post-translational regulation of MITF-M expression and activity (Gallus gallus)
MAPK-dependent phosphorylation of KARS (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
MAPK1-dependent phosphorylation of MITF-M (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
RPS6KA1-dependent phosphorylation of MITF-M (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
Signal Transduction (Gallus gallus)
Intracellular signaling by second messengers (Gallus gallus)
PIP3 activates AKT signaling (Gallus gallus)
Negative regulation of the PI3K/AKT network (Gallus gallus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
Activator:PI3K [plasma membrane] (Gallus gallus)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
Activator:PI3K [plasma membrane] (Gallus gallus)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
MAPK family signaling cascades (Gallus gallus)
MAPK1/MAPK3 signaling (Gallus gallus)
RAF/MAP kinase cascade (Gallus gallus)
RAS GEFs promote RAS nucleotide exchange (Gallus gallus)
RAS GEFs [plasma membrane] (Gallus gallus)
GRB2:SOS1:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by SCF-KIT (Gallus gallus)
Activation of RAS by p-KIT bound SOS1 (Gallus gallus)
GRB2:SOS1:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
Autophosphorylation of KIT (Gallus gallus)
KIT:sSCF dimer:KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
KIT:sSCF dimer:KIT:type I KIT binding TKIs: [plasma membrane] (Gallus gallus)
KIT:sSCF dimer:KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
Dimerization of KIT upon SCF binding (Gallus gallus)
KIT:sSCF dimer [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
KIT:sSCF dimer:KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
Dimerization of STATs (Gallus gallus)
p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Gallus gallus)
SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Gallus gallus)
SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
Dimerization of sSCF (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
Direct recruitment of PI3K to p-KIT (Gallus gallus)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
Disassociation and translocation of STATs to the nucleus (Gallus gallus)
p-JAK2:SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Gallus gallus)
SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
GRB2 is indirectly recruited to p-KIT through SHP2 (Gallus gallus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
GRB2:SOS interacts with p-KIT (Gallus gallus)
GRB2:SOS1:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
Indirect recruitment of GAB2 to p-KIT (Gallus gallus)
GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Gallus gallus)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
Interaction of KIT and sSCF (Gallus gallus)
KIT:sSCF dimer [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
Interaction of other adapter proteins with p-KIT (Gallus gallus)
Adapter proteins:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
Interaction of other tyrosine kinases with p-KIT (Gallus gallus)
Tyrosine kinases:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
JAK2 binds to p-KIT (Gallus gallus)
JAK2:SFKS:p-KIT complex [plasma membrane] (Gallus gallus)
SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
KIT binds type I TKIs (Gallus gallus)
KIT:sSCF dimer:KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
KIT:sSCF dimer:KIT:type I KIT binding TKIs: [plasma membrane] (Gallus gallus)
KIT:sSCF dimer:KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
Phosphorylation of GAB2 by SFKs (Gallus gallus)
GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
Phosphorylation of JAK2 (Gallus gallus)
JAK2:SFKS:p-KIT complex [plasma membrane] (Gallus gallus)
SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
p-JAK2:SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
Phosphorylation of SHP2 by SFKs (Gallus gallus)
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Gallus gallus)
SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
Phosphorylation of STATs (Gallus gallus)
p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Gallus gallus)
SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Gallus gallus)
SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
Phosphorylation of p-KIT on Y900 by Src kinases (Gallus gallus)
SFKs:p-8Y-KIT:sSCF dimer:p-8Y-KIT [plasma membrane] (Gallus gallus)
p-8Y-KIT:sSCF dimer:p-8Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
Recruitment of STATs (Gallus gallus)
p-JAK2:SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Gallus gallus)
SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
Regulation of KIT signaling (Gallus gallus)
Interaction of SHP1 and KIT (Gallus gallus)
PTPN6:p-c-Kit complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
LNK binds to p-KIT and inhibit downstream signaling (Gallus gallus)
LNK:p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
Phosphorylation of APS (Gallus gallus)
APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Gallus gallus)
SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
p-APS dimer:p-KIT complex [plasma membrane] (Gallus gallus)
SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
Recruitment of CBL to KIT (Gallus gallus)
CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Gallus gallus)
Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Gallus gallus)
GRB2:SOS1:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
p-APS dimer:p-KIT complex [plasma membrane] (Gallus gallus)
SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Gallus gallus)
GRB2:SOS1:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
p-APS dimer:p-KIT complex [plasma membrane] (Gallus gallus)
SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
SHP2 interacts with p-KIT (Gallus gallus)
SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Gallus gallus)
SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
Synthesis of PIP3 from PIP2 by PI3K (Gallus gallus)
PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
SFKs:p-KIT complex [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
sSCF dimer [extracellular region] (Gallus gallus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
KITLG [extracellular region]
(Gallus gallus)
Participates
as a component of
p-8Y-KIT:sSCF dimer:p-8Y-KIT [plasma membrane] (Gallus gallus)
KIT:sSCF dimer:KIT [plasma membrane] (Gallus gallus)
KIT:sSCF dimer [plasma membrane] (Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Gallus gallus)
as an input of
Interaction of KIT and sSCF (Gallus gallus)
as an output of
Dimerization of sSCF (Gallus gallus)
Inferred From
sSCF dimer [extracellular region]
(Homo sapiens)
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