Reactome | BUB3 [cytosol]

BUB3 [cytosol]

Stable Identifier

R-GGA-141416

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

BUB3, A0A1L1RRQ2

Locations in the PathwayBrowser

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Cell Cycle (Gallus gallus)

- Cell Cycle Checkpoints (Gallus gallus)
  - Mitotic Spindle Checkpoint (Gallus gallus)
    - Amplification of signal from the kinetochores (Gallus gallus)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Gallus gallus)
        
        MAD2 associates with the Mad1 kinetochore complex (Gallus gallus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Gallus gallus)
        
        Mad1:kinetochore complex [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        Mad1:kinetochore complex [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Gallus gallus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Gallus gallus)
        
        Mad1:kinetochore complex [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        Mad1 binds kinetochore (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        Mad1:kinetochore complex [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        Release of activated MAD2 from kinetochores (Gallus gallus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Gallus gallus)
        
        Mad1:kinetochore complex [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        Mad1:kinetochore complex [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
    - Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Gallus gallus)
      - Inactivation of APC/C via direct inhibition of the APC/C complex (Gallus gallus)
        
        Binding of the MCC complex to the APC/C complex (Gallus gallus)
        
        MCC:APC/C complex [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        Formation of the MCC complex (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
- Cell Cycle, Mitotic (Gallus gallus)
  - M Phase (Gallus gallus)
    - Mitotic Metaphase and Anaphase (Gallus gallus)
      - Mitotic Anaphase (Gallus gallus)
        
        Separation of Sister Chromatids (Gallus gallus)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Gallus gallus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
        
        Microtubule-bound kinetochore [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
    - Mitotic Prometaphase (Gallus gallus)
      - EML4 and NUDC in mitotic spindle formation (Gallus gallus)
        
        EML4 recruits NUDC to mitotic spindle (Gallus gallus)
        
        Microtubule-bound kinetochore [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Gallus gallus)
        
        Microtubule-bound kinetochore [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
      - Resolution of Sister Chromatid Cohesion (Gallus gallus)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Gallus gallus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Gallus gallus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
        
        Microtubule-bound kinetochore [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        Kinetochore assembly (Gallus gallus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Gallus gallus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        Microtubule-bound kinetochore [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Gallus gallus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
        
        Microtubule-bound kinetochore [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
        
        Microtubule-bound kinetochore [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Gallus gallus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
        
        Microtubule-bound kinetochore [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Gallus gallus)
        
        Microtubule-bound kinetochore [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
  - Regulation of mitotic cell cycle (Gallus gallus)
    - APC/C-mediated degradation of cell cycle proteins (Gallus gallus)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Gallus gallus)
        
        APC/C:Cdc20 mediated degradation of mitotic proteins (Gallus gallus)
        
        APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Gallus gallus)
        
        APC-Cdc20 mediated degradation of Nek2A (Gallus gallus)
        
        Association of Nek2A with MCC:APC/C (Gallus gallus)
        
        MCC:APC/C complex [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        Nek2A:MCC:APC/C complex [cytosol] (Gallus gallus)
        
        MCC:APC/C complex [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        Degradation of multiubiquitinated Nek2A (Gallus gallus)
        
        MCC:APC/C complex [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        Multiubiquitinated Nek2A [cytosol] (Gallus gallus)
        
        Nek2A:MCC:APC/C complex [cytosol] (Gallus gallus)
        
        MCC:APC/C complex [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        Multiubiquitination of Nek2A (Gallus gallus)
        
        Multiubiquitinated Nek2A [cytosol] (Gallus gallus)
        
        Nek2A:MCC:APC/C complex [cytosol] (Gallus gallus)
        
        MCC:APC/C complex [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        Nek2A:MCC:APC/C complex [cytosol] (Gallus gallus)
        
        MCC:APC/C complex [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Gallus gallus)
        
        Association of Cyclin A with the APC/C (Gallus gallus)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Gallus gallus)
        
        MCC:APC/C complex [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        MCC:APC/C complex [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        Degradation multiubiquitinated Cyclin A (Gallus gallus)
        
        MCC:APC/C complex [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Gallus gallus)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Gallus gallus)
        
        MCC:APC/C complex [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Gallus gallus)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Gallus gallus)
        
        MCC:APC/C complex [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        MCC:APC/C complex [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Gallus gallus)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Gallus gallus)
        
        MCC:APC/C complex [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Gallus gallus)
        
        MCC:APC/C complex [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        hBUBR1:hBUB3:MAD2* complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
      - Regulation of APC/C activators between G1/S and early anaphase (Gallus gallus)
        
        Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Gallus gallus)
        
        Inactivation of APC/C via direct inhibition of the APC/C complex (Gallus gallus)
        
        Binding of the MCC complex to the APC/C complex (Gallus gallus)
        
        MCC:APC/C complex [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        Formation of the MCC complex (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)

Signal Transduction (Gallus gallus)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Gallus gallus)
  - Signaling by Rho GTPases (Gallus gallus)
    - RHO GTPase Effectors (Gallus gallus)
      - RHO GTPases Activate Formins (Gallus gallus)
        
        AURKB phosphorylates DIAPH2-2 at kinetochores (Gallus gallus)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        Mitotic checkpoint complex [cytosol] (Gallus gallus)
        
        BUB3 [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A1L1RRQ2

Gene Names

BUB3

Reference Genes

ENSEMBL:ENSGALG00000009681

UCSC:A0A1L1RRQ2 BUB3

Other Identifiers

423949

GO:0000776

GO:0005634

GO:0005654

GO:0007094

GO:0008608

GO:0022414

GO:0033597

GO:0034501

GO:0043130

GO:0043226

GO:0043229

GO:0051321

GO:0051983

GO:1990298

GT_A_87_P200478

GgaAffx.13124.1.S1_s_at

Participates

as a component of

as an input of

Formation of the MCC complex (Gallus gallus)

Inferred From

BUB3 [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSGALT00010004174, ENSGALP00010002471, ENSGALG00010001832

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