Reactome | gbp1 [cytosol]

gbp1 [cytosol]

Stable Identifier

R-DRE-9947851-4

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

GGC-C588-GBP2, Q6DHP7

Locations in the PathwayBrowser

Expand all

Immune System (Danio rerio)

- Cytokine Signaling in Immune system (Danio rerio)
  - Interferon Signaling (Danio rerio)
    - Antimicrobial mechanism of IFN-stimulated genes (Danio rerio)
      - GBP-mediated host defense (Danio rerio)
        
        FNTA:PGGT1B geranylgeranylates GBP2 (Danio rerio)
        
        Homologues of GGC-C588-GBP2 [cytosol] (Danio rerio)
        
        gbp1 [cytosol] (Danio rerio)
        
        GBP1:GBP2:GBP3:GBP4 forms higher-order structures (Danio rerio)
        
        LPS:(GBP1:GBP2:GBP3:GBP4) oligomer [cytosol] (Danio rerio)
        
        LPS:GBP1 oligomer:GBP2:GBP3:GBP4:GDP [cytosol] (Danio rerio)
        
        Homologues of GGC-C588-GBP2 [cytosol] (Danio rerio)
        
        gbp1 [cytosol] (Danio rerio)
        
        LPS:GBP1 oligomer:GBP2:GBP3:GBP4:GTP [cytosol] (Danio rerio)
        
        Homologues of GGC-C588-GBP2 [cytosol] (Danio rerio)
        
        gbp1 [cytosol] (Danio rerio)
        
        GBP2, GBP3, GBP4 bind to GBP1 oligomer on the bacterial surface (Danio rerio)
        
        Homologues of GGC-C588-GBP2 [cytosol] (Danio rerio)
        
        gbp1 [cytosol] (Danio rerio)
        
        LPS:GBP1 oligomer:GBP2:GBP3:GBP4:GTP [cytosol] (Danio rerio)
        
        Homologues of GGC-C588-GBP2 [cytosol] (Danio rerio)
        
        gbp1 [cytosol] (Danio rerio)
        
        GGC-GBP2, GGC-GBP5 bind furin (Danio rerio)
        
        GGC-GBP2, GGC-GBP5 [cytosol] (Danio rerio)
        
        Homologues of GGC-C588-GBP2 [cytosol] (Danio rerio)
        
        gbp1 [cytosol] (Danio rerio)
- Innate Immune System (Danio rerio)
  - Non-canonical inflammasome activation (Danio rerio)
    - CASP4 inflammasome assembly (Danio rerio)
      - CASP4 binds exposed LPS on the bacterial surface (Danio rerio)
        
        CASP4:LPS:(GBP1:GBP2:GBP3:GBP4:GDP) oligomer [cytosol] (Danio rerio)
        
        LPS:(GBP1:GBP2:GBP3:GBP4) oligomer [cytosol] (Danio rerio)
        
        LPS:GBP1 oligomer:GBP2:GBP3:GBP4:GDP [cytosol] (Danio rerio)
        
        Homologues of GGC-C588-GBP2 [cytosol] (Danio rerio)
        
        gbp1 [cytosol] (Danio rerio)
        
        LPS:(GBP1:GBP2:GBP3:GBP4) oligomer [cytosol] (Danio rerio)
        
        LPS:GBP1 oligomer:GBP2:GBP3:GBP4:GDP [cytosol] (Danio rerio)
        
        Homologues of GGC-C588-GBP2 [cytosol] (Danio rerio)
        
        gbp1 [cytosol] (Danio rerio)
      - CASP4 forms dimers on the bacterial surface (Danio rerio)
        
        2xCASP4:LPS:(GBP1:GBP2:GBP3:GBP4:GDP) oligomer [cytosol] (Danio rerio)
        
        LPS:(GBP1:GBP2:GBP3:GBP4) oligomer [cytosol] (Danio rerio)
        
        LPS:GBP1 oligomer:GBP2:GBP3:GBP4:GDP [cytosol] (Danio rerio)
        
        Homologues of GGC-C588-GBP2 [cytosol] (Danio rerio)
        
        gbp1 [cytosol] (Danio rerio)
        
        CASP4:LPS:(GBP1:GBP2:GBP3:GBP4:GDP) oligomer [cytosol] (Danio rerio)
        
        LPS:(GBP1:GBP2:GBP3:GBP4) oligomer [cytosol] (Danio rerio)
        
        LPS:GBP1 oligomer:GBP2:GBP3:GBP4:GDP [cytosol] (Danio rerio)
        
        Homologues of GGC-C588-GBP2 [cytosol] (Danio rerio)
        
        gbp1 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q6DHP7

Gene Names

gbp1

Reference Genes

BioGPS Gene:436615 gbp1

ENSEMBL:ENSDARG00000038668

KEGG:dre:436615 gbp1

Monarch:436615 gbp1

NCBI Gene:436615 gbp1

UCSC:Q6DHP7 gbp1

Reference Transcript

RefSeq:NM_001002343.1 gbp1

Other Identifiers

13091423

436615

A_15_P115237

CJ004369

CUST_25093_PI428451953

CUST_6055_PI428451958

DRER07313

DRER31424

DRER39601

DRER43267

Dr.14275.1.A1_at

ENSDART00000056460

ENSDART00000056460_1

ENSDART00000056460_2

GO:0003924

GO:0005525

GO:0016787

GT_Xhyb_NM_001002343.1_158286

GT_Xhyb_XM_005171375.1_79061

GT_Xhyb_XM_005171376.1_249535

JP004768

LOLS07014

LOLT00173

MADDr01009465

NM_001002343

OTTDART00000027592

OTTDART00000027593

Participates

as a member of

Homologues of GGC-C588-GBP2 [cytosol] (Danio rerio)

Other forms of this molecule

gbp1 [cytosol]

phospho-gbp1 [cytosol]

gbp1 [cytosol]

Inferred From

GGC-C588-GBP2 [cytosol] (Homo sapiens)

Modified Residues

Name

S-geranylgeranyl-L-cysteine (geranylgeranyl group) at 588 (in Homo sapiens)

Coordinate

588

Modification

geranylgeranyl group

PsiMod Name

S-geranylgeranyl-L-cysteine [MOD:00113]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.

Cross References

RefSeq

NP_001002343.1

ENSEMBL

ENSDARP00000056459, ENSDART00000056460, ENSDARG00000038668

ZFIN

ZDB-GENE-040718-32