Reactome | asb12b [cytosol]

asb12b [cytosol]

Stable Identifier

R-DRE-975414

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

ASB12, Q68EL0

Locations in the PathwayBrowser

Expand all

Immune System (Danio rerio)

- Adaptive Immune System (Danio rerio)
  - Class I MHC mediated antigen processing & presentation (Danio rerio)
    - Antigen processing: Ubiquitination & Proteasome degradation (Danio rerio)
      - Interaction of E3 with substrate and E2-Ub complex (Danio rerio)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Danio rerio)
        
        ASB family [cytosol] (Danio rerio)
        
        asb12b [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Danio rerio)
        
        ASB family [cytosol] (Danio rerio)
        
        asb12b [cytosol] (Danio rerio)
      - Polyubiquitination of substrate (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Danio rerio)
        
        ASB family [cytosol] (Danio rerio)
        
        asb12b [cytosol] (Danio rerio)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Danio rerio)
        
        ASB family [cytosol] (Danio rerio)
        
        asb12b [cytosol] (Danio rerio)
        
        E3:Ub:substrate [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Danio rerio)
        
        ASB family [cytosol] (Danio rerio)
        
        asb12b [cytosol] (Danio rerio)
      - Release of E3 from polyubiquitinated substrate (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Danio rerio)
        
        ASB family [cytosol] (Danio rerio)
        
        asb12b [cytosol] (Danio rerio)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Danio rerio)
        
        ASB family [cytosol] (Danio rerio)
        
        asb12b [cytosol] (Danio rerio)
      - Transfer of Ub from E2 to substrate and release of E2 (Danio rerio)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Danio rerio)
        
        ASB family [cytosol] (Danio rerio)
        
        asb12b [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Danio rerio)
        
        ASB family [cytosol] (Danio rerio)
        
        asb12b [cytosol] (Danio rerio)
        
        E3:Ub:substrate [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Danio rerio)
        
        ASB family [cytosol] (Danio rerio)
        
        asb12b [cytosol] (Danio rerio)

Metabolism of proteins (Danio rerio)

- Post-translational protein modification (Danio rerio)
  - Neddylation (Danio rerio)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Danio rerio)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        asb12b [cytosol] (Danio rerio)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        asb12b [cytosol] (Danio rerio)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Danio rerio)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Danio rerio)
        
        CRL E3 ubiquitin ligases [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        asb12b [cytosol] (Danio rerio)
      - CRL E3 ubiquitin ligases [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        asb12b [cytosol] (Danio rerio)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Danio rerio)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Danio rerio)
        
        CRL E3 ubiquitin ligases [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        asb12b [cytosol] (Danio rerio)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        asb12b [cytosol] (Danio rerio)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Danio rerio)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        asb12b [cytosol] (Danio rerio)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        asb12b [cytosol] (Danio rerio)
    - NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Danio rerio)
      - CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        asb12b [cytosol] (Danio rerio)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        asb12b [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q68EL0

Gene Names

asb12b

Reference Genes

BioGPS Gene:445507 asb12b

CTD Gene:445507 asb12b

ENSEMBL:ENSDARG00000037558

KEGG:dre:445507 asb12b

Monarch:445507 asb12b

NCBI Gene:445507 asb12b

UCSC:Q68EL0 asb12b

Reference Transcript

Other Identifiers

13013699

13287540

445507

A_15_P119735

A_15_P375070

CUST_9291_PI428451958

DRER06942

ENSDART00000054693

ENSDART00000054693_1

ENSDART00000054693_2

GO:0005515

GT_Xhyb_NM_001004009.2_85901

GT_Xhyb_XM_005157142.1_50411

MADDr01009784

NM_001004009

OTTDART00000028810

XM_696486

Participates

as a member of

Inferred From

ASB12 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_068069296.1, NP_001004009.1

ENSEMBL

ENSDARG00000037558, ENSDART00000181597, ENSDART00000188835, ENSDART00000189048, ENSDARP00000154117, ENSDARP00000054692, ENSDART00000054693, ENSDARP00000157540, ENSDARG00000116721, ENSDARP00000149233, ENSDARG00000113049

ZFIN

ZDB-GENE-040822-25

PRO

Q68EL0

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