Reactome | asb12 [cytosol]

asb12 [cytosol]

Stable Identifier

R-DRE-975414

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

ASB12, A2CEZ8

Locations in the PathwayBrowser

Expand all

Immune System (Danio rerio)

- Adaptive Immune System (Danio rerio)
  - Class I MHC mediated antigen processing & presentation (Danio rerio)
    - Antigen processing: Ubiquitination & Proteasome degradation (Danio rerio)
      - Interaction of E3 with substrate and E2-Ub complex (Danio rerio)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Danio rerio)
        
        ASB family [cytosol] (Danio rerio)
        
        asb12 [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Danio rerio)
        
        ASB family [cytosol] (Danio rerio)
        
        asb12 [cytosol] (Danio rerio)
      - Polyubiquitination of substrate (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Danio rerio)
        
        ASB family [cytosol] (Danio rerio)
        
        asb12 [cytosol] (Danio rerio)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Danio rerio)
        
        ASB family [cytosol] (Danio rerio)
        
        asb12 [cytosol] (Danio rerio)
        
        E3:Ub:substrate [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Danio rerio)
        
        ASB family [cytosol] (Danio rerio)
        
        asb12 [cytosol] (Danio rerio)
      - Release of E3 from polyubiquitinated substrate (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Danio rerio)
        
        ASB family [cytosol] (Danio rerio)
        
        asb12 [cytosol] (Danio rerio)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Danio rerio)
        
        ASB family [cytosol] (Danio rerio)
        
        asb12 [cytosol] (Danio rerio)
      - Transfer of Ub from E2 to substrate and release of E2 (Danio rerio)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Danio rerio)
        
        ASB family [cytosol] (Danio rerio)
        
        asb12 [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Danio rerio)
        
        ASB family [cytosol] (Danio rerio)
        
        asb12 [cytosol] (Danio rerio)
        
        E3:Ub:substrate [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Danio rerio)
        
        ASB family [cytosol] (Danio rerio)
        
        asb12 [cytosol] (Danio rerio)

Metabolism of proteins (Danio rerio)

- Post-translational protein modification (Danio rerio)
  - Neddylation (Danio rerio)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Danio rerio)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        asb12 [cytosol] (Danio rerio)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        asb12 [cytosol] (Danio rerio)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Danio rerio)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Danio rerio)
        
        CRL E3 ubiquitin ligases [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        asb12 [cytosol] (Danio rerio)
      - CRL E3 ubiquitin ligases [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        asb12 [cytosol] (Danio rerio)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Danio rerio)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Danio rerio)
        
        CRL E3 ubiquitin ligases [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        asb12 [cytosol] (Danio rerio)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        asb12 [cytosol] (Danio rerio)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Danio rerio)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        asb12 [cytosol] (Danio rerio)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        asb12 [cytosol] (Danio rerio)
    - NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Danio rerio)
      - CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        asb12 [cytosol] (Danio rerio)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        asb12 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:A2CEZ8

Gene Names

asb12

Reference Genes

BioGPS Gene:322927 asb12

CTD Gene:322927 asb12

ENSEMBL:ENSDARG00000017086

ENSEMBL:ENSDARG00000017086.10 asb12

ENSEMBL:ENSDARG00000110715.1 asb12

KEGG Gene (Danio rerio):322927 asb12

Monarch:322927 asb12

NCBI Gene:322927 asb12

Reference Transcript

RefSeq:NM_001126376.1 asb12

Other Identifiers

13203361

322927

A_15_P145736

CJ000321

CJ000322

CJ000323

DRER02976

ENSDART00000023306

ENSDART00000023306_1

ENSDART00000023306_2

GO:0000151

GO:0003824

GO:0005515

GO:0016567

GO:0016740

GO:0023052

GO:0035556

GO:0036211

GO:0061630

GO:0140096

GT_Xhyb_NM_001126376.1_191195

GT_Xhyb_XM_005165109.1_240495

JP000321

JP000322

JP000323

LOLS09676

MADDr01007039

OTTDART00000021022

XM_684295

Participates

as a member of

Inferred From

ASB12 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001119848.1

ZFIN

ZDB-GENE-030131-1647

Ensembl

ENSDARG00000017086, ENSDARP00000014061, ENSDARP00000146752, ENSDARG00000110715, ENSDART00000023306, ENSDART00000189035

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