Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
cul3b [cytosol]
Stable Identifier
R-DRE-8952516
Type
Protein [EntityWithAccessionedSequence]
Species
Danio rerio
Compartment
cytosol
Synonyms
G76-NEDD8-K712-CUL3, B3DIU1
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Danio rerio)
Cellular responses to stress (Danio rerio)
Cellular response to chemical stress (Danio rerio)
KEAP1-NFE2L2 pathway (Danio rerio)
CUL3:RBX1 ubiquitinates KEAP1 (Danio rerio)
SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
cul3b [cytosol] (Danio rerio)
SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Danio rerio)
ub-KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
cul3b [cytosol] (Danio rerio)
KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Danio rerio)
p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
cul3b [cytosol] (Danio rerio)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
cul3b [cytosol] (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
cul3b [cytosol] (Danio rerio)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
cul3b [cytosol] (Danio rerio)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
cul3b [cytosol] (Danio rerio)
MAP1LC3B binds KEAP1 and SQSTM1 (Danio rerio)
MAP1LC3B:SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Danio rerio)
SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Danio rerio)
ub-KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
cul3b [cytosol] (Danio rerio)
SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Danio rerio)
ub-KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
cul3b [cytosol] (Danio rerio)
NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
cul3b [cytosol] (Danio rerio)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
cul3b [cytosol] (Danio rerio)
RBX1:CUL3 dissociates from forming autophagosome (Danio rerio)
MAP1LC3B:SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Danio rerio)
SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Danio rerio)
ub-KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
cul3b [cytosol] (Danio rerio)
NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
cul3b [cytosol] (Danio rerio)
SESN1,SESN1 bind SQSTM1 and KEAP1 (Danio rerio)
SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
cul3b [cytosol] (Danio rerio)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
cul3b [cytosol] (Danio rerio)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Danio rerio)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
cul3b [cytosol] (Danio rerio)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Danio rerio)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
cul3b [cytosol] (Danio rerio)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
cul3b [cytosol] (Danio rerio)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Danio rerio)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
cul3b [cytosol] (Danio rerio)
p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
cul3b [cytosol] (Danio rerio)
p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
cul3b [cytosol] (Danio rerio)
Metabolism of proteins (Danio rerio)
Post-translational protein modification (Danio rerio)
Neddylation (Danio rerio)
AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Danio rerio)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
NEDD8-CUL3:RBX1:BTB [cytosol] (Danio rerio)
cul3b [cytosol] (Danio rerio)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Danio rerio)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
NEDD8-CUL3:RBX1:BTB [cytosol] (Danio rerio)
cul3b [cytosol] (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
cul3b [cytosol] (Danio rerio)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
cul3b [cytosol] (Danio rerio)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
cul3b [cytosol] (Danio rerio)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Danio rerio)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
cul3b [cytosol] (Danio rerio)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Danio rerio)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
cul3b [cytosol] (Danio rerio)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
cul3b [cytosol] (Danio rerio)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Danio rerio)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
cul3b [cytosol] (Danio rerio)
External Reference Information
External Reference
UniProt:B3DIU1
Gene Names
cul3b
Reference Genes
BioGPS Gene:572370 cul3b
CTD Gene:572370 cul3b
ENSEMBL:ENSDARG00000100108
KEGG:dre:572370 cul3b
Monarch:572370 cul3b
NCBI Gene:572370 cul3b
UCSC:B3DIU1 cul3b
Reference Transcript
RefSeq:NM_001190485.1 cul3b
Other Identifiers
13017984
13303054
572370
A_15_P164826
A_15_P239681
A_15_P424810
A_15_P433795
A_15_P518492
CJ012070
CJ012071
CUST_12764_PI428451958
CUST_1447_PI428451953
CUST_3057_PI424165973
CUST_3058_PI424165973
CUST_3059_PI424165973
CUST_3060_PI424165973
CUST_3061_PI424165973
CUST_3062_PI424165973
CUST_3063_PI424165973
CUST_3064_PI424165973
DRER26629
ENSDART00000004682
ENSDART00000004682_2
ENSDART00000081991
ENSDART00000082022
ENSDART00000082022_1
ENSDART00000082022_2
ENSDART00000102422
ENSDART00000102422_y_1
ENSDART00000102422_y_2
GO:0006511
GO:0031461
GO:0031625
GT_Spec_NM_001190485.1_386215
LOLS05193
LOLS07017
XM_696079
XM_696179
Participates
as a component of
NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
NEDD8-CUL3:RBX1:BTB [cytosol] (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
ub-KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Danio rerio)
Other forms of this molecule
cul3b [nucleoplasm]
cul3b [cytosol]
Inferred From
G76-NEDD8-K712-CUL3 [cytosol]
(Homo sapiens)
Modified Residues
Name
neddylated lysine (monoNEDD8 [cytosol]) at 712 (in Homo sapiens)
Coordinate
712
Modification
monoNEDD8 [cytosol]
PsiMod Name
neddylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a nedd8 protein.
Cross References
RefSeq
NP_001177414.1
ENSEMBL
ENSDARP00000132246
,
ENSDARG00000100108
,
ENSDART00000159032
ZFIN
ZDB-GENE-081007-1
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text