Reactome | wsb2 [cytosol]

wsb2 [cytosol]

Stable Identifier

R-DRE-8863349

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

WSB2, B8JKT2

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Danio rerio)

- Post-translational protein modification (Danio rerio)
  - Neddylation (Danio rerio)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Danio rerio)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        wsb2 [cytosol] (Danio rerio)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        wsb2 [cytosol] (Danio rerio)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Danio rerio)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Danio rerio)
        
        CRL E3 ubiquitin ligases [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        wsb2 [cytosol] (Danio rerio)
      - CRL E3 ubiquitin ligases [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        wsb2 [cytosol] (Danio rerio)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Danio rerio)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Danio rerio)
        
        CRL E3 ubiquitin ligases [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        wsb2 [cytosol] (Danio rerio)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        wsb2 [cytosol] (Danio rerio)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Danio rerio)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        wsb2 [cytosol] (Danio rerio)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        wsb2 [cytosol] (Danio rerio)
    - NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Danio rerio)
      - CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        wsb2 [cytosol] (Danio rerio)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        wsb2 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:B8JKT2

Gene Names

wsb2

Reference Genes

BioGPS Gene:100307075 wsb2

ENSEMBL:ENSDARG00000058608

KEGG:dre:100307075 wsb2

Monarch:100307075 wsb2

NCBI Gene:100307075 wsb2

UCSC:B8JKT2 wsb2

Reference Transcript

RefSeq:NM_001243384.1 wsb2

Other Identifiers

100307075

13202268

A_15_P297626

DRER12013

ENSDART00000081499

ENSDART00000081499_2

GO:0005515

GO:0035556

GT_Spec_NM_001243384.1_238136

Participates

as a member of

CUL5-box protein [cytosol] (Danio rerio)

Inferred From

WSB2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001230313.1

ENSEMBL

ENSDART00000133587, ENSDARG00000058608, ENSDARP00000119398

ZFIN

ZDB-GENE-081104-26