Reactome | pik3ca [cytosol]

pik3ca [cytosol]

Stable Identifier

R-DRE-74787

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

PIK3CA, F1QAD7

Locations in the PathwayBrowser

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Developmental Biology (Danio rerio)

- Nervous system development (Danio rerio)
  - Axon guidance (Danio rerio)
    - RET signaling (Danio rerio)
      - p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Danio rerio)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K alpha [cytosol] (Danio rerio)
        
        pik3ca [cytosol] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K alpha [cytosol] (Danio rerio)
        
        pik3ca [cytosol] (Danio rerio)

Immune System (Danio rerio)

- Adaptive Immune System (Danio rerio)
  - Costimulation by the CD28 family (Danio rerio)
    - CD28 co-stimulation (Danio rerio)
      - CD28 dependent PI3K/Akt signaling (Danio rerio)
        
        CD28 bound PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
        
        CD28:PI3K [plasma membrane] (Danio rerio)
        
        PI3K alpha [cytosol] (Danio rerio)
        
        pik3ca [cytosol] (Danio rerio)
        
        pik3ca [cytosol] (Danio rerio)
        
        PI3K binds CD28 (Danio rerio)
        
        CD28:PI3K [plasma membrane] (Danio rerio)
        
        PI3K alpha [cytosol] (Danio rerio)
        
        pik3ca [cytosol] (Danio rerio)
        
        PI3K alpha [cytosol] (Danio rerio)
        
        pik3ca [cytosol] (Danio rerio)
- Cytokine Signaling in Immune system (Danio rerio)
  - FLT3 Signaling (Danio rerio)
    - Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Danio rerio)
      - Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Danio rerio)
        
        pik3ca [cytosol] (Danio rerio)
      - pik3ca [cytosol] (Danio rerio)
    - Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Danio rerio)
      - active FLT3:p-Y GRB10:PI3K [plasma membrane] (Danio rerio)
        
        pik3ca [cytosol] (Danio rerio)
      - pik3ca [cytosol] (Danio rerio)
  - Signaling by Interleukins (Danio rerio)
    - Interleukin-2 family signaling (Danio rerio)
      - Interleukin receptor SHC signaling (Danio rerio)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Danio rerio)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Danio rerio)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K alpha [cytosol] (Danio rerio)
        
        pik3ca [cytosol] (Danio rerio)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K alpha [cytosol] (Danio rerio)
        
        pik3ca [cytosol] (Danio rerio)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K alpha [cytosol] (Danio rerio)
        
        pik3ca [cytosol] (Danio rerio)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K alpha [cytosol] (Danio rerio)
        
        pik3ca [cytosol] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K alpha [cytosol] (Danio rerio)
        
        pik3ca [cytosol] (Danio rerio)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Danio rerio)
      - Interleukin receptor SHC signaling (Danio rerio)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Danio rerio)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Danio rerio)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K alpha [cytosol] (Danio rerio)
        
        pik3ca [cytosol] (Danio rerio)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K alpha [cytosol] (Danio rerio)
        
        pik3ca [cytosol] (Danio rerio)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K alpha [cytosol] (Danio rerio)
        
        pik3ca [cytosol] (Danio rerio)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K alpha [cytosol] (Danio rerio)
        
        pik3ca [cytosol] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K alpha [cytosol] (Danio rerio)
        
        pik3ca [cytosol] (Danio rerio)
      - Regulation of signaling by CBL (Danio rerio)
        
        CBL ubiquitinates PI3K (Danio rerio)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        K63polyUb-p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        K63polyUb-PI3K alpha [cytosol] (Danio rerio)
        
        pik3ca [cytosol] (Danio rerio)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K alpha [cytosol] (Danio rerio)
        
        pik3ca [cytosol] (Danio rerio)
        
        CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Danio rerio)
        
        FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K alpha [cytosol] (Danio rerio)
        
        pik3ca [cytosol] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K alpha [cytosol] (Danio rerio)
        
        pik3ca [cytosol] (Danio rerio)
- Innate Immune System (Danio rerio)
  - DAP12 interactions (Danio rerio)
    - DAP12 signaling (Danio rerio)
      - PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Danio rerio)
        
        PI3K [cytosol] (Danio rerio)
        
        PI3K-catalytic subunit [cytosol] (Danio rerio)
        
        pik3ca [cytosol] (Danio rerio)
        
        PI3K [cytosol] (Danio rerio)
        
        PI3K-catalytic subunit [cytosol] (Danio rerio)
        
        pik3ca [cytosol] (Danio rerio)
  - Fc epsilon receptor (FCERI) signaling (Danio rerio)
    - Role of LAT2/NTAL/LAB on calcium mobilization (Danio rerio)
      - PI3K associates with phosphorylated GAB2 (Danio rerio)
        
        PI3K [cytosol] (Danio rerio)
        
        PI3K-catalytic subunit [cytosol] (Danio rerio)
        
        pik3ca [cytosol] (Danio rerio)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Danio rerio)
        
        PI3K [cytosol] (Danio rerio)
        
        PI3K-catalytic subunit [cytosol] (Danio rerio)
        
        pik3ca [cytosol] (Danio rerio)
      - Phosphorylation of PIP2 to PIP3 by PI3K (Danio rerio)
        
        PI3K [cytosol] (Danio rerio)
        
        PI3K-catalytic subunit [cytosol] (Danio rerio)
        
        pik3ca [cytosol] (Danio rerio)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Danio rerio)
        
        PI3K [cytosol] (Danio rerio)
        
        PI3K-catalytic subunit [cytosol] (Danio rerio)
        
        pik3ca [cytosol] (Danio rerio)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Danio rerio)
    - Role of phospholipids in phagocytosis (Danio rerio)
      - PI3K binds to p-6Y-SYK (Danio rerio)
        
        PI3K [cytosol] (Danio rerio)
        
        PI3K-catalytic subunit [cytosol] (Danio rerio)
        
        pik3ca [cytosol] (Danio rerio)
        
        PI3K:p-6Y-SYK [plasma membrane] (Danio rerio)
        
        PI3K [cytosol] (Danio rerio)
        
        PI3K-catalytic subunit [cytosol] (Danio rerio)
        
        pik3ca [cytosol] (Danio rerio)
      - PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
        
        PI3K [cytosol] (Danio rerio)
        
        PI3K-catalytic subunit [cytosol] (Danio rerio)
        
        pik3ca [cytosol] (Danio rerio)
        
        PI3K:p-6Y-SYK [plasma membrane] (Danio rerio)
        
        PI3K [cytosol] (Danio rerio)
        
        PI3K-catalytic subunit [cytosol] (Danio rerio)
        
        pik3ca [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:F1QAD7

Gene Names

pik3ca

Reference Genes

BioGPS Gene:561737 pik3ca

ENSEMBL:ENSDARG00000075456

KEGG Gene (Danio rerio):561737 pik3ca

Monarch:561737 pik3ca

NCBI Gene:561737 pik3ca

Reference Transcript

Other Identifiers

12980854

13275690

561737

A_15_P267271

A_15_P352465

CJ011331

CJ012389

CJ012664

CJ013233

CJ013304

CJ013387

CJ013995

CJ014464

CUST_1359_PI428451953

CUST_29600_PI428451953

DRER20523

ENSDART00000112973

GO:0000902

GO:0003674

GO:0005575

GO:0005622

GO:0005737

GO:0005886

GO:0005942

GO:0005943

GO:0005944

GO:0006629

GO:0007165

GO:0008150

GO:0009058

GO:0014065

GO:0016020

GO:0016301

GO:0016303

GO:0016310

GO:0016477

GO:0016740

GO:0030154

GO:0032991

GO:0035005

GO:0036092

GO:0040007

GO:0040011

GO:0046854

GO:0046934

GO:0048015

GO:0048696

GO:0048856

GO:0048870

GO:0052742

GO:0052812

GT_Xhyb_XM_002663811.2_328365

GT_Xhyb_XM_005174426.1_354635

JP011533

LOL01537

LOL02044

LOL04811

LOL04812

LOL04813

LOL04814

LOL04815

LOL04816

LOL04817

LOL05351

XM_685143

Participant Of

input

hasComponent

hasMember

PI3K-catalytic subunit [cytosol]

Inferred From

PIK3CA [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_009304452.1, XP_009304451.1, XP_005155911.1, XP_017213837.1

Ensembl

ENSDART00000114004, ENSDARP00000138914, ENSDART00000188223, ENSDART00000158616, ENSDARG00000075456, ENSDARP00000103176, ENSDARP00000148626

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