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PIK3CA [cytosol]
Stable Identifier
R-DRE-74787
Type
Protein [EntityWithAccessionedSequence]
Species
Danio rerio
Compartment
cytosol
Synonyms
F1QAD7
Locations in the PathwayBrowser
Expand all
Developmental Biology (Danio rerio)
Axon guidance (Danio rerio)
RET signaling (Danio rerio)
p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Danio rerio)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Hemostasis (Danio rerio)
Cell surface interactions at the vascular wall (Danio rerio)
Tie2 Signaling (Danio rerio)
Interaction of Tie2 and p85 of PI3K (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
p85 bound to Tie2 [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Platelet activation, signaling and aggregation (Danio rerio)
GPVI-mediated activation cascade (Danio rerio)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Danio rerio)
PI3K alpha, beta, gamma [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Immune System (Danio rerio)
Cytokine Signaling in Immune system (Danio rerio)
Signaling by Interleukins (Danio rerio)
Interleukin-2 family signaling (Danio rerio)
Interleukin receptor SHC signaling (Danio rerio)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Danio rerio)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Danio rerio)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Danio rerio)
Interleukin receptor SHC signaling (Danio rerio)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Danio rerio)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Danio rerio)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Regulation of signaling by CBL (Danio rerio)
CBL ubiquitinates PI3K (Danio rerio)
FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
K63polyUb-p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
K63polyUb-PI3K alpha [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Danio rerio)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Metabolism (Danio rerio)
Metabolism of lipids (Danio rerio)
Phospholipid metabolism (Danio rerio)
PI Metabolism (Danio rerio)
Synthesis of PIPs at the plasma membrane (Danio rerio)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Danio rerio)
PIK3C(1) [cytosol] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PIK3CA:PIK3R2 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PIK3CA:PIK3R3 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Danio rerio)
PIK3(2) [cytosol] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PIK3CA:PIK3R2 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PIK3CA:PIK3R3 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Signal Transduction (Danio rerio)
Intracellular signaling by second messengers (Danio rerio)
PIP3 activates AKT signaling (Danio rerio)
Negative regulation of the PI3K/AKT network (Danio rerio)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Danio rerio)
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
Activator:PI3K [plasma membrane] (Danio rerio)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
ESRs:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PI3K:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
Activator:PI3K [plasma membrane] (Danio rerio)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
ESRs:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PI3K:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
RAC1,RAC2,RHOG activate PI3K (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Signaling by Erythropoietin (Danio rerio)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Danio rerio)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Danio rerio)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Danio rerio)
PI3K alpha, gamma [cytosol] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PI3K alpha, gamma [cytosol] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Danio rerio)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Danio rerio)
PI3K alpha, gamma [cytosol] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PI3K alpha, gamma [cytosol] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI3K alpha, gamma [cytosol] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PI3K bound to EPOR [plasma membrane] (Danio rerio)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PI3K [plasma membrane] (Danio rerio)
PI3K alpha, gamma [cytosol] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Danio rerio)
PI3K alpha, gamma [cytosol] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Danio rerio)
PI3K alpha, gamma [cytosol] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Signaling by GPCR (Danio rerio)
GPCR downstream signalling (Danio rerio)
G alpha (q) signalling events (Danio rerio)
G alpha (q) inhibits PI3K alpha (Danio rerio)
G-protein alpha (q/11):PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by EGFR (Danio rerio)
GAB1 signalosome (Danio rerio)
PI3K binds to EGF:EGFR:GRB2:GAB1 (Danio rerio)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Danio rerio)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Signaling by ERBB2 (Danio rerio)
PI3K events in ERBB2 signaling (Danio rerio)
Binding of PI3K to ERBB2:P-ERBB3 heterodimer (Danio rerio)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Danio rerio)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Danio rerio)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Danio rerio)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Danio rerio)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Danio rerio)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Signaling by ERBB4 (Danio rerio)
PI3K events in ERBB4 signaling (Danio rerio)
Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Danio rerio)
PI3K:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Danio rerio)
PI3K:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Signaling by FGFR (Danio rerio)
Signaling by FGFR1 (Danio rerio)
Downstream signaling of activated FGFR1 (Danio rerio)
PI-3K cascade:FGFR1 (Danio rerio)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Danio rerio)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Danio rerio)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Signaling by FGFR2 (Danio rerio)
Downstream signaling of activated FGFR2 (Danio rerio)
PI-3K cascade:FGFR2 (Danio rerio)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Danio rerio)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Danio rerio)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Signaling by FGFR3 (Danio rerio)
Downstream signaling of activated FGFR3 (Danio rerio)
PI-3K cascade:FGFR3 (Danio rerio)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Danio rerio)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Danio rerio)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Signaling by FGFR4 (Danio rerio)
Downstream signaling of activated FGFR4 (Danio rerio)
PI-3K cascade:FGFR4 (Danio rerio)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Danio rerio)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Danio rerio)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Signaling by Insulin receptor (Danio rerio)
Insulin receptor signalling cascade (Danio rerio)
IRS-mediated signalling (Danio rerio)
PI3K Cascade (Danio rerio)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Danio rerio)
PI3K-containing complexes [plasma membrane] (Danio rerio)
Activated FGFR bound to PI3K [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Signaling by MET (Danio rerio)
MET activates PI3K/AKT signaling (Danio rerio)
MET bound PI3K generates PIP3 (Danio rerio)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Phosphorylated GAB1 recruits PI3K to MET (Danio rerio)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Signaling by NTRKs (Danio rerio)
Signaling by NTRK1 (TRKA) (Danio rerio)
PI3K/AKT activation (Danio rerio)
Active IRS recruits PI3K to the plasma membrane and activates it (Danio rerio)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PI3K produces PIP3 and other phosphatidyl inositides (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Signaling by PDGF (Danio rerio)
Downstream signal transduction (Danio rerio)
PI3-kinase binds to the active receptor (Danio rerio)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Danio rerio)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Signaling by SCF-KIT (Danio rerio)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Synthesis of PIP3 from PIP2 by PI3K (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Danio rerio)
IGF1R signaling cascade (Danio rerio)
IRS-related events triggered by IGF1R (Danio rerio)
IRS-mediated signalling (Danio rerio)
PI3K Cascade (Danio rerio)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Danio rerio)
PI3K-containing complexes [plasma membrane] (Danio rerio)
Activated FGFR bound to PI3K [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
Signaling by VEGF (Danio rerio)
VEGFA-VEGFR2 Pathway (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K/VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K [plasma membrane] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
p-AXL binds PI3K (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
PIK3CA [cytosol] (Danio rerio)
External Reference Information
External Reference
UniProt:F1QAD7
Reference Genes
BioGPS Gene:561737
dbSNP Gene:561737
ENSEMBL:ENSDARG00000075456
KEGG Gene (Danio rerio):561737
Monarch:561737
NCBI Gene:561737
Reference Transcript
RefSeq:XM_009306177.2
RefSeq:XM_005155854.3
RefSeq:XM_009306176.2
RefSeq:XM_017358348.1
Other Identifiers
561737
BX548160
ENSDARG00000075456
ENSDARP00000103176
ENSDARP00000138914
ENSDARP00000148626
ENSDART00000114004
ENSDART00000158616
ENSDART00000188223
EntrezGene:561737
GO:0000166
GO:0000902
GO:0003674
GO:0005524
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005886
GO:0005942
GO:0005943
GO:0006464
GO:0006468
GO:0006629
GO:0006950
GO:0007165
GO:0008150
GO:0009058
GO:0014065
GO:0016020
GO:0016301
GO:0016303
GO:0016310
GO:0016477
GO:0016740
GO:0030154
GO:0030168
GO:0032991
GO:0035005
GO:0036092
GO:0040007
GO:0040011
GO:0043167
GO:0046854
GO:0046934
GO:0048015
GO:0048696
GO:0048856
GO:0048870
IPR000341
IPR000403
IPR001263
IPR002420
IPR003113
IPR008290
IPR011009
IPR015433
IPR016024
IPR018936
IPR029071
IPR036940
LOL01537
LOL02044
LOL04811
LOL04812
LOL04813
LOL04814
LOL04815
LOL04816
LOL04817
LOL05351
PF00454
PF00613
PF00792
PF00794
PF02192
pik3ca
pik3ca-201
pik3ca-202
pik3ca-203
SM00142
SM00143
SM00144
SM00145
SM00146
UPI0000F1F225
XM_009306176
XM_009306177
XM_021479874
XP_009304451
XP_009304452
XP_021335549
ZDB-GENE-130409-1
Participant Of
hasMember
PI3K-catalytic subunit [cytosol]
input
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
hasComponent
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane]
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane]
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane]
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane]
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane]
K63polyUb-PI3K alpha [cytosol]
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane]
PI3K alpha [cytosol]
PIK3CA:PIK3R1 [cytosol]
PIK3CA:PIK3R2 [cytosol]
PIK3CA:PIK3R3 [cytosol]
Inferred From
PIK3CA [cytosol] (Homo sapiens)
Cross References
RefSeq
XP_017213837.1
,
XP_009304451.1
,
XP_005155911.1
,
XP_009304452.1
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