Reactome | PIK3CA [cytosol]

PIK3CA [cytosol]

Stable Identifier

R-DRE-74787

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

F1QAD7

Locations in the PathwayBrowser

Expand all

Developmental Biology (Danio rerio)

- Axon guidance (Danio rerio)
  - RET signaling (Danio rerio)
    - p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Danio rerio)
      - 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K alpha [cytosol] (Danio rerio)
        
        PIK3CA [cytosol] (Danio rerio)
      - p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K alpha [cytosol] (Danio rerio)
        
        PIK3CA [cytosol] (Danio rerio)

Immune System (Danio rerio)

- Cytokine Signaling in Immune system (Danio rerio)
  - Signaling by Interleukins (Danio rerio)
    - Interleukin-2 family signaling (Danio rerio)
      - Interleukin receptor SHC signaling (Danio rerio)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Danio rerio)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Danio rerio)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K alpha [cytosol] (Danio rerio)
        
        PIK3CA [cytosol] (Danio rerio)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K alpha [cytosol] (Danio rerio)
        
        PIK3CA [cytosol] (Danio rerio)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K alpha [cytosol] (Danio rerio)
        
        PIK3CA [cytosol] (Danio rerio)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K alpha [cytosol] (Danio rerio)
        
        PIK3CA [cytosol] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K alpha [cytosol] (Danio rerio)
        
        PIK3CA [cytosol] (Danio rerio)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Danio rerio)
      - Interleukin receptor SHC signaling (Danio rerio)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Danio rerio)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Danio rerio)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K alpha [cytosol] (Danio rerio)
        
        PIK3CA [cytosol] (Danio rerio)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K alpha [cytosol] (Danio rerio)
        
        PIK3CA [cytosol] (Danio rerio)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K alpha [cytosol] (Danio rerio)
        
        PIK3CA [cytosol] (Danio rerio)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K alpha [cytosol] (Danio rerio)
        
        PIK3CA [cytosol] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K alpha [cytosol] (Danio rerio)
        
        PIK3CA [cytosol] (Danio rerio)
      - Regulation of signaling by CBL (Danio rerio)
        
        CBL ubiquitinates PI3K (Danio rerio)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        K63polyUb-p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        K63polyUb-PI3K alpha [cytosol] (Danio rerio)
        
        PIK3CA [cytosol] (Danio rerio)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K alpha [cytosol] (Danio rerio)
        
        PIK3CA [cytosol] (Danio rerio)
        
        CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Danio rerio)
        
        FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K alpha [cytosol] (Danio rerio)
        
        PIK3CA [cytosol] (Danio rerio)
        
        p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        PI3K alpha [cytosol] (Danio rerio)
        
        PIK3CA [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:F1QAD7

Reference Genes

BioGPS Gene:561737

dbSNP Gene:561737

ENSEMBL:ENSDARG00000075456

KEGG Gene (Danio rerio):561737

Monarch:561737

NCBI Gene:561737

Reference Transcript

Other Identifiers

561737

BX548160

ENSDARG00000075456

ENSDARP00000103176

ENSDARP00000138914

ENSDARP00000148626

ENSDART00000114004

ENSDART00000158616

ENSDART00000188223

EntrezGene:561737

GO:0000166

GO:0000902

GO:0003674

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005886

GO:0005942

GO:0005943

GO:0006464

GO:0006468

GO:0006629

GO:0006950

GO:0007165

GO:0008150

GO:0009058

GO:0014065

GO:0016020

GO:0016301

GO:0016303

GO:0016310

GO:0016477

GO:0016740

GO:0030154

GO:0030168

GO:0032991

GO:0035005

GO:0036092

GO:0040007

GO:0040011

GO:0043167

GO:0046854

GO:0046934

GO:0048015

GO:0048696

GO:0048856

GO:0048870

IPR000341

IPR000403

IPR001263

IPR002420

IPR003113

IPR008290

IPR011009

IPR015433

IPR016024

IPR018936

IPR029071

IPR036940

LOL01537

LOL02044

LOL04811

LOL04812

LOL04813

LOL04814

LOL04815

LOL04816

LOL04817

LOL05351

PF00454

PF00613

PF00792

PF00794

PF02192

pik3ca

pik3ca-201

pik3ca-202

pik3ca-203

SM00142

SM00143

SM00144

SM00145

SM00146

UPI0000F1F225

XM_009306176

XM_009306177

XM_021479874

XP_009304451

XP_009304452

XP_021335549

ZDB-GENE-130409-1

Participant Of

hasMember

PI3K-catalytic subunit [cytosol]

input

hasComponent

Inferred From

PIK3CA [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_017213837.1, XP_009304451.1, XP_005155911.1, XP_009304452.1