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cyld [cytosol]
Stable Identifier
R-DRE-741420
Type
Protein [EntityWithAccessionedSequence]
Species
Danio rerio
Compartment
cytosol
Synonyms
CYLD, E7FEV5
Locations in the PathwayBrowser
Expand all
Immune System (Danio rerio)
Innate Immune System (Danio rerio)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Danio rerio)
NOD1/2 Signaling Pathway (Danio rerio)
CYLD deubiquitinates NEMO (Danio rerio)
cyld [cytosol] (Danio rerio)
Metabolism of proteins (Danio rerio)
Post-translational protein modification (Danio rerio)
Deubiquitination (Danio rerio)
Ub-specific processing proteases (Danio rerio)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Danio rerio)
CYLD:K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol] (Danio rerio)
cyld [cytosol] (Danio rerio)
cyld [cytosol] (Danio rerio)
Signal Transduction (Danio rerio)
Death Receptor Signaling (Danio rerio)
TNF signaling (Danio rerio)
Regulation of TNFR1 signaling (Danio rerio)
CHUK, IKBKB phosphorylate CYLD at S418 (Danio rerio)
cyld [cytosol] (Danio rerio)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Danio rerio)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Danio rerio)
CYLD:SPATA2:LUBAC [cytosol] (Danio rerio)
cyld [cytosol] (Danio rerio)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Danio rerio)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Danio rerio)
CYLD:SPATA2:LUBAC [cytosol] (Danio rerio)
cyld [cytosol] (Danio rerio)
CLIP3 and CYLD bind TNF signaling complex (Danio rerio)
CYLD:CLIP3:TNF:TNFR1:TRADD:K63pUb-RIP1:TRAF2:BIRC2/3 [plasma membrane] (Danio rerio)
cyld [cytosol] (Danio rerio)
cyld [cytosol] (Danio rerio)
K63polyUb-RIPK1 is deubiquitinated (Danio rerio)
RIPK1 deubiquitinases [cytosol] (Danio rerio)
cyld [cytosol] (Danio rerio)
MIB2 binds CYLD (Danio rerio)
MIB2:CYLD:UBE2D2 [cytosol] (Danio rerio)
cyld [cytosol] (Danio rerio)
cyld [cytosol] (Danio rerio)
MIB2 ubiquitinates CYLD at K338, K530 (Danio rerio)
MIB2:CYLD:UBE2D2 [cytosol] (Danio rerio)
cyld [cytosol] (Danio rerio)
OPTN recruits CYLD to the TNFR1 complex (Danio rerio)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Danio rerio)
cyld [cytosol] (Danio rerio)
cyld [cytosol] (Danio rerio)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Danio rerio)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Danio rerio)
CYLD:SPATA2:LUBAC [cytosol] (Danio rerio)
cyld [cytosol] (Danio rerio)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Danio rerio)
CYLD:SPATA2:LUBAC [cytosol] (Danio rerio)
cyld [cytosol] (Danio rerio)
TNFR1-induced proapoptotic signaling (Danio rerio)
TRADD:TRAF2:RIP1 binds FADD (Danio rerio)
RIPK1 deubiquitinases [cytosol] (Danio rerio)
cyld [cytosol] (Danio rerio)
TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 (Danio rerio)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Danio rerio)
CYLD:SPATA2:LUBAC [cytosol] (Danio rerio)
cyld [cytosol] (Danio rerio)
External Reference Information
External Reference
UniProt:E7FEV5
Gene Names
cyld
Reference Genes
BioGPS Gene:556823 cyld
ENSEMBL:ENSDARG00000060058
Monarch:556823 cyld
NCBI Gene:556823 cyld
UCSC:E7FEV5 cyld
Other Identifiers
13238273
556823
A_15_P362805
A_15_P368390
A_15_P369555
CJ010389
CJ014439
CUST_16912_PI428451953
CUST_16913_PI428451953
CUST_3201_PI428451958
DRER12662
DRER47008
DRER48262
ENSDART00000084249
ENSDART00000084249_1
ENSDART00000084249_2
GO:0004843
GO:0016579
GT_Xhyb_XM_005169019.1_369785
GT_Xhyb_XM_679725.4_369775
JP010787
XM_679725
XM_692877
Participates
as a component of
CYLD:K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol] (Danio rerio)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Danio rerio)
CYLD:CLIP3:TNF:TNFR1:TRADD:K63pUb-RIP1:TRAF2:BIRC2/3 [plasma membrane] (Danio rerio)
MIB2:CYLD:UBE2D2 [cytosol] (Danio rerio)
CYLD:SPATA2:LUBAC [cytosol] (Danio rerio)
as an input of
OPTN recruits CYLD to the TNFR1 complex (Danio rerio)
CLIP3 and CYLD bind TNF signaling complex (Danio rerio)
CHUK, IKBKB phosphorylate CYLD at S418 (Danio rerio)
MIB2 binds CYLD (Danio rerio)
as a member of
RIPK1 deubiquitinases [cytosol] (Danio rerio)
Other forms of this molecule
cyld [cytosol]
phospho-cyld [cytosol]
Inferred From
CYLD [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSDARP00000154149
,
ENSDART00000193359
,
ENSDARP00000123913
,
ENSDARG00000060058
,
ENSDART00000150229
ZFIN
ZDB-GENE-061108-2
PDB
3WXG
,
3WXE
,
3WXF
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