Reactome | rpl8 [cytosol]

rpl8 [cytosol]

Stable Identifier

R-DRE-72490

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

RPL8, Q6P0V6

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Danio rerio)

- Nonsense-Mediated Decay (NMD) (Danio rerio)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Danio rerio)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl8 [cytosol] (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl8 [cytosol] (Danio rerio)
    - SMG6 hydrolyzes mRNA with premature termination codon (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl8 [cytosol] (Danio rerio)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl8 [cytosol] (Danio rerio)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl8 [cytosol] (Danio rerio)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl8 [cytosol] (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl8 [cytosol] (Danio rerio)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Danio rerio)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Danio rerio)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl8 [cytosol] (Danio rerio)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl8 [cytosol] (Danio rerio)
- rRNA processing (Danio rerio)
  - rRNA processing in the nucleus and cytosol (Danio rerio)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Danio rerio)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl8 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q6P0V6

Gene Names

rpl8

Reference Genes

BioGPS Gene:393686 rpl8

ENSEMBL:ENSDARG00000014867

KEGG:dre:393686 rpl8

Monarch:393686 rpl8

NCBI Gene:393686 rpl8

UCSC:Q6P0V6 rpl8

Reference Transcript

RefSeq:NM_200713.1 rpl8

Other Identifiers

12926751

12926753

12926755

12926757

12926759

12926775

12932251

12932253

12932255

12932257

12932259

12932275

12935239

12935241

12935243

12935245

12935247

12935263

12935335

12935337

12935339

12935341

12935343

12935359

13268078

393686

A_15_P102274

A_15_P105625

A_15_P381390

A_15_P727676

BC065432

CJ014335

CUST_22348_PI428451953

DRER00752

DRER32572

DRER38930

DRER45496

Dr.4091.1.S1_at

ENSDART00000006948

ENSDART00000006948_1

ENSDART00000006948_2

GO:0003723

GO:0003735

GO:0005198

GO:0005840

GO:0006412

GO:0015934

GT_Xhyb_NM_200713.1_289455

LOLS09264

MADDr01008626

NM_200713

OTTDART00000026218

OTTDART00000026219

Participates

as a component of

Other forms of this molecule

rpl8 [nucleoplasm]

Inferred From

RPL8 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_957007.1

ENSEMBL

ENSDARP00000005651, ENSDART00000006948, ENSDARP00000115147, ENSDART00000140039, ENSDARG00000014867

ZFIN

ZDB-GENE-040426-1670

PRO

Q6P0V6

PDB

7OYB, 7OYA

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