Reactome | fj02g05 [cytosol]

fj02g05 [cytosol]

Stable Identifier

R-DRE-72482

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

RPL5, Q6IQB1

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Danio rerio)

- Nonsense-Mediated Decay (NMD) (Danio rerio)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Danio rerio)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        fj02g05 [cytosol] (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        fj02g05 [cytosol] (Danio rerio)
    - SMG6 hydrolyzes mRNA with premature termination codon (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        fj02g05 [cytosol] (Danio rerio)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        fj02g05 [cytosol] (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        fj02g05 [cytosol] (Danio rerio)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Danio rerio)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Danio rerio)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        fj02g05 [cytosol] (Danio rerio)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        fj02g05 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q6IQB1

Gene Names

fj02g05

Reference Genes

BioGPS Gene:415196 fj02g05

CTD Gene:415196 fj02g05

ENSEMBL:ENSDARG00000015862

ENSEMBL:ENSDARG00000015862.12 fj02g05

KEGG Gene (Danio rerio):415196 fj02g05

Monarch:415196 fj02g05

NCBI Gene:415196 fj02g05

Reference Transcript

RefSeq:NM_001002106.1 fj02g05

Other Identifiers

13214201

415196

A_15_P103757

A_15_P111481

A_15_P185671

A_15_P207831

A_15_P663211

A_15_P726442

BC076208

CUST_18748_PI428451953

CUST_62_PI428451961

DRER28351

Dr.8.2.S1_at

ENSDART00000020299

ENSDART00000020299_1

ENSDART00000020299_2

GO:0000027

GO:0003723

GO:0003735

GO:0005198

GO:0005737

GO:0005829

GO:0005840

GO:0006412

GO:0008097

GO:0022625

GO:0042254

GO:0043226

GO:0065003

GO:1990904

GT_Spec_NM_001002106.1_230475

LOLS06965

MADDr01009304

NM_001002106

OTTDART00000024491

Participates

as a component of

Inferred From

RPL5 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001002106.1

ZFIN

ZDB-GENE-040625-93

Ensembl

ENSDART00000127695, ENSDARG00000015862, ENSDARP00000106359

PDB

7OYA, 7OYB

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