Reactome | rpl39 [cytosol]

rpl39 [cytosol]

Stable Identifier

R-DRE-72472

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

RPL39, Q6IMW8

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Danio rerio)

- Nonsense-Mediated Decay (NMD) (Danio rerio)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Danio rerio)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl39 [cytosol] (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl39 [cytosol] (Danio rerio)
    - SMG6 hydrolyzes mRNA with premature termination codon (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl39 [cytosol] (Danio rerio)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl39 [cytosol] (Danio rerio)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl39 [cytosol] (Danio rerio)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl39 [cytosol] (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl39 [cytosol] (Danio rerio)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Danio rerio)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Danio rerio)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl39 [cytosol] (Danio rerio)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl39 [cytosol] (Danio rerio)
- rRNA processing (Danio rerio)
  - rRNA processing in the nucleus and cytosol (Danio rerio)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Danio rerio)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl39 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q6IMW8

Gene Names

rpl39

Reference Genes

BioGPS Gene:415168 rpl39

ENSEMBL:ENSDARG00000036316

KEGG:dre:415168 rpl39

Monarch:415168 rpl39

NCBI Gene:415168 rpl39

UCSC:Q6IMW8 rpl39

Reference Transcript

RefSeq:NM_001002078.3 rpl39

Other Identifiers

12925365

12925367

12925369

12925371

12925373

13015926

13282356

415168

A_15_P114941

A_15_P630471

DRER06567

DRER21847

DRER44596

DRER45252

Dr.4412.6.S1_at

ENSDART00000052761

ENSDART00000052761_1

ENSDART00000052761_2

GO:0003735

GO:0005198

GO:0005840

GO:0006412

GT_Spec_NM_001002078.2_254215

LOLS05347

MADDr01009289

NM_001002078

OTTDART00000029196

Participates

as a component of

Other forms of this molecule

rpl39 [cytosol]

Inferred From

RPL39,RPL39L [cytosol] (Homo sapiens)

RPL39 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001002078.1

ENSEMBL

ENSDARG00000036316, ENSDARP00000157246, ENSDART00000052761, ENSDARP00000052760, ENSDART00000187749

ZFIN

ZDB-GENE-040625-51

PDB

7OYB, 7OYA

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