Reactome | rpl19 [cytosol]

rpl19 [cytosol]

Stable Identifier

R-DRE-72424

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

RPL19, Q6P5L3

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Danio rerio)

- Nonsense-Mediated Decay (NMD) (Danio rerio)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Danio rerio)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl19 [cytosol] (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl19 [cytosol] (Danio rerio)
    - SMG6 hydrolyzes mRNA with premature termination codon (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl19 [cytosol] (Danio rerio)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl19 [cytosol] (Danio rerio)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl19 [cytosol] (Danio rerio)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl19 [cytosol] (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl19 [cytosol] (Danio rerio)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Danio rerio)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Danio rerio)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl19 [cytosol] (Danio rerio)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl19 [cytosol] (Danio rerio)
- rRNA processing (Danio rerio)
  - rRNA processing in the nucleus and cytosol (Danio rerio)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Danio rerio)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl19 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q6P5L3

Gene Names

rpl19

Reference Genes

BioGPS Gene:406489 rpl19

ENSEMBL:ENSDARG00000013307

KEGG:dre:406489 rpl19

Monarch:406489 rpl19

NCBI Gene:406489 rpl19

UCSC:Q6P5L3 rpl19

Reference Transcript

RefSeq:NM_213208.1 rpl19

Other Identifiers

13165408

406489

A_15_P107521

CUST_14304_PI428451953

DRER23880

DRER36546

Dr.9746.3.S1_at

ENSDART00000018975

ENSDART00000018975_1

ENSDART00000018975_2

GO:0003723

GO:0003735

GO:0005198

GO:0005840

GO:0006412

GO:0022625

GT_Spec_NM_213208.1_280685

LOLS10367

MADDr01008836

NM_213208

OTTDART00000024259

Participates

as a component of

Inferred From

RPL19 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_998373.1

ENSEMBL

ENSDART00000121728, ENSDARG00000013307, ENSDARP00000105649

ZFIN

ZDB-GENE-040426-2290

PRO

Q6P5L3

PDB

7OYB, 7OYA

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