Reactome | rps3a [cytosol]

rps3a [cytosol]

Stable Identifier

R-DRE-72373

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

RPS3A, Q6PBY1

Locations in the PathwayBrowser

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Metabolism of RNA (Danio rerio)

- Nonsense-Mediated Decay (NMD) (Danio rerio)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Danio rerio)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps3a [cytosol] (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps3a [cytosol] (Danio rerio)
    - SMG6 hydrolyzes mRNA with premature termination codon (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps3a [cytosol] (Danio rerio)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps3a [cytosol] (Danio rerio)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps3a [cytosol] (Danio rerio)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps3a [cytosol] (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps3a [cytosol] (Danio rerio)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Danio rerio)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Danio rerio)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps3a [cytosol] (Danio rerio)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps3a [cytosol] (Danio rerio)
- rRNA processing (Danio rerio)
  - rRNA processing in the nucleus and cytosol (Danio rerio)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Danio rerio)
      - 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps3a [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q6PBY1

Gene Names

rps3a

Reference Genes

BioGPS Gene:337240 rps3a

ENSEMBL:ENSDARG00000035692

KEGG:dre:337240 rps3a

Monarch:337240 rps3a

NCBI Gene:337240 rps3a

UCSC:Q6PBY1 rps3a

Other Identifiers

12926579

12926581

12926583

12926585

12926587

12926589

12926591

12926593

12926595

12926597

12926599

12932221

12932223

12932225

12932227

12932229

12932231

12932233

12932235

12932237

12932239

12932241

12938215

12938217

12938219

12938221

12938223

12938225

12938227

12938229

12938231

12938233

12938235

12939911

12939913

12939915

12939917

12939919

12939921

12939923

12939925

12939927

12939929

12939931

12946967

337240

A_15_P113311

A_15_P117272

A_15_P119082

A_15_P119848

A_15_P402570

A_15_P564397

A_15_P725066

A_15_P739741

BC078649

DRER06358

DRER36251

DRER42019

Dr.907.1.S1_at

ENSDART00000051763

ENSDART00000051763_1

ENSDART00000051763_2

GO:0003735

GO:0005198

GO:0005840

GO:0006412

LOLS07045

MADDr01007740

NM_200059

OTTDART00000023916

Participates

as a component of

Other forms of this molecule

rps3a [nucleoplasm]

Inferred From

RPS3A [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_956353.1

ENSEMBL

ENSDARP00000051762, ENSDARG00000115378, ENSDARP00000148857, ENSDART00000051763, ENSDARP00000145062, ENSDARG00000114628, ENSDART00000188228, ENSDARG00000035692, ENSDART00000191146

ZFIN

ZDB-GENE-030131-9184

PRO

Q6PBY1

PDB

7OYB, 7OYA

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