Reactome | rps19 [cytosol]

rps19 [cytosol]

Stable Identifier

R-DRE-72343

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

RPS19, Q6PBW7

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Danio rerio)

- Nonsense-Mediated Decay (NMD) (Danio rerio)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Danio rerio)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps19 [cytosol] (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps19 [cytosol] (Danio rerio)
    - SMG6 hydrolyzes mRNA with premature termination codon (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps19 [cytosol] (Danio rerio)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps19 [cytosol] (Danio rerio)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps19 [cytosol] (Danio rerio)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps19 [cytosol] (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps19 [cytosol] (Danio rerio)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Danio rerio)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Danio rerio)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps19 [cytosol] (Danio rerio)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps19 [cytosol] (Danio rerio)
- rRNA processing (Danio rerio)
  - rRNA processing in the nucleus and cytosol (Danio rerio)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Danio rerio)
      - 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps19 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q6PBW7

Gene Names

rps19

Reference Genes

BioGPS Gene:393723 rps19

ENSEMBL:ENSDARG00000030602

KEGG:dre:393723 rps19

Monarch:393723 rps19

NCBI Gene:393723 rps19

UCSC:Q6PBW7 rps19

Reference Transcript

RefSeq:NM_200750.1 rps19

Other Identifiers

12919721

12919723

12919725

12919749

12919751

12919753

12919755

12919757

12919759

12933291

12933293

12933295

12933319

12933321

12933323

12933325

12933327

12933329

12935127

12935129

12935131

12935155

12935157

12935159

12935161

12935163

12935165

13038556

393723

A_15_P194716

A_15_P467465

A_15_P750381

CUST_15863_PI428451953

DRER05909

DRER35488

DRER56942

Dr.15372.2.S1_at

ENSDART00000048599

ENSDART00000048599_1

ENSDART00000048599_2

GO:0003735

GO:0005198

GO:0005634

GO:0005737

GO:0005840

GO:0006412

GO:0022626

GO:0030154

GO:0030218

GO:0035284

GO:0042541

GO:0043009

GO:0045088

GO:0045646

GO:0048821

GO:0048856

GO:0072332

GO:1990904

GT_Spec_NM_200750.1_150946

GT_Xhyb_XM_005158094.1_189725

LOLS10316

MADDr01008646

NM_200750

OTTDART00000028534

OTTDART00000028535

XM_697258

Participates

as a component of

Other forms of this molecule

rps19 [nucleoplasm]

Inferred From

RPS19 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_957044.1

ENSEMBL

ENSDART00000181520, ENSDART00000048599, ENSDARP00000048598, ENSDARP00000152819, ENSDARG00000030602

ZFIN

ZDB-GENE-040426-1716

PDB

7OYA

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