Reactome | ptbp1a [nucleoplasm]

ptbp1a [nucleoplasm]

Stable Identifier

R-DRE-71923

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

nucleoplasm

Synonyms

PTBP1, Q503D3

Locations in the PathwayBrowser

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Metabolism of RNA (Danio rerio)

- Processing of Capped Intron-Containing Pre-mRNA (Danio rerio)
  - Formation of pre-mRNPs (Danio rerio)
    - Alternative Splicing Factors [nucleoplasm] (Danio rerio)
      - ptbp1a [nucleoplasm] (Danio rerio)
    - capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Danio rerio)
      - Alternative Splicing Factors [nucleoplasm] (Danio rerio)
        
        ptbp1a [nucleoplasm] (Danio rerio)
  - mRNA 3'-end processing (Danio rerio)
    - mRNA Polyadenylation (Danio rerio)
      - Core CPA complex binds capped pre-mRNA (Danio rerio)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Danio rerio)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Danio rerio)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Danio rerio)
        
        Alternative Splicing Factors [nucleoplasm] (Danio rerio)
        
        ptbp1a [nucleoplasm] (Danio rerio)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Danio rerio)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Danio rerio)
        
        Alternative Splicing Factors [nucleoplasm] (Danio rerio)
        
        ptbp1a [nucleoplasm] (Danio rerio)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS (Danio rerio)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Danio rerio)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Danio rerio)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Danio rerio)
        
        Alternative Splicing Factors [nucleoplasm] (Danio rerio)
        
        ptbp1a [nucleoplasm] (Danio rerio)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Danio rerio)
        
        Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Danio rerio)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Danio rerio)
        
        Alternative Splicing Factors [nucleoplasm] (Danio rerio)
        
        ptbp1a [nucleoplasm] (Danio rerio)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS (Danio rerio)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Danio rerio)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Danio rerio)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Danio rerio)
        
        Alternative Splicing Factors [nucleoplasm] (Danio rerio)
        
        ptbp1a [nucleoplasm] (Danio rerio)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Danio rerio)
        
        Spliceosomal A complex (pre-mRNA cleaved at intronal PAS) [nucleoplasm] (Danio rerio)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Danio rerio)
        
        Alternative Splicing Factors [nucleoplasm] (Danio rerio)
        
        ptbp1a [nucleoplasm] (Danio rerio)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at proximal 3'UTR PAS (Danio rerio)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Danio rerio)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Danio rerio)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Danio rerio)
        
        Alternative Splicing Factors [nucleoplasm] (Danio rerio)
        
        ptbp1a [nucleoplasm] (Danio rerio)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Danio rerio)
        
        Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Danio rerio)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Danio rerio)
        
        Alternative Splicing Factors [nucleoplasm] (Danio rerio)
        
        ptbp1a [nucleoplasm] (Danio rerio)
      - PP1 dephosphorylates RNA Pol II (Danio rerio)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Danio rerio)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Danio rerio)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Danio rerio)
        
        Alternative Splicing Factors [nucleoplasm] (Danio rerio)
        
        ptbp1a [nucleoplasm] (Danio rerio)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Danio rerio)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Danio rerio)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Danio rerio)
        
        Alternative Splicing Factors [nucleoplasm] (Danio rerio)
        
        ptbp1a [nucleoplasm] (Danio rerio)
      - RBBP6 activates CPSF complex (Danio rerio)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Danio rerio)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Danio rerio)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Danio rerio)
        
        Alternative Splicing Factors [nucleoplasm] (Danio rerio)
        
        ptbp1a [nucleoplasm] (Danio rerio)
        
        Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Danio rerio)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Danio rerio)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Danio rerio)
        
        Alternative Splicing Factors [nucleoplasm] (Danio rerio)
        
        ptbp1a [nucleoplasm] (Danio rerio)
  - mRNA Splicing (Danio rerio)
    - mRNA Splicing - Major Pathway (Danio rerio)
      - Formation of the Spliceosomal C complex containing intron lariat (Danio rerio)
        
        Spliceosomal B* complex [nucleoplasm] (Danio rerio)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Danio rerio)
        
        Alternative Splicing Factors [nucleoplasm] (Danio rerio)
        
        ptbp1a [nucleoplasm] (Danio rerio)
        
        Spliceosomal C complex [nucleoplasm] (Danio rerio)
        
        Alternative Splicing Factors [nucleoplasm] (Danio rerio)
        
        ptbp1a [nucleoplasm] (Danio rerio)
      - Formation of the Spliceosomal P complex and exon ligation (Danio rerio)
        
        Spliceosomal C* complex [nucleoplasm] (Danio rerio)
        
        Alternative Splicing Factors [nucleoplasm] (Danio rerio)
        
        ptbp1a [nucleoplasm] (Danio rerio)
        
        Spliceosomal P complex [nucleoplasm] (Danio rerio)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Danio rerio)
        
        Alternative Splicing Factors [nucleoplasm] (Danio rerio)
        
        ptbp1a [nucleoplasm] (Danio rerio)

External Reference Information

External Reference

UniProt:Q503D3

Gene Names

ptbp1a

Reference Genes

BioGPS Gene:323490 ptbp1a

CTD Gene:323490 ptbp1a

ENSEMBL:ENSDARG00000019362

KEGG:dre:323490 ptbp1a

Monarch:323490 ptbp1a

NCBI Gene:323490 ptbp1a

UCSC:Q503D3 ptbp1a

Reference Transcript

RefSeq:NM_001020477.1 ptbp1a

Other Identifiers

13081434

13278344

323490

A_15_P110769

A_15_P292461

CUST_2951_PI428451958

DRER02165

DRER40310

Dr.20803.1.S1_at

Dr.5460.1.A1_at

ENSDART00000017668

ENSDART00000017668_1

ENSDART00000017668_2

GO:0003676

GO:0003723

GO:0005634

GO:0006397

GO:0016071

GT_Xhyb_NM_001020477.1_310555

GT_Xhyb_XM_005163380.1_344495

GT_Xhyb_XM_005163381.1_344485

LOLS13364

LOLS15486

MADDr01011287

NM_001020477

XM_696770

ZV700S00003428

ZV700S00005621

Participates

as a member of

Alternative Splicing Factors [nucleoplasm] (Danio rerio)

as an input of

PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Danio rerio)

as a component of

FGFR2 IIIc-specific splicing complex [nucleoplasm] (Danio rerio)

Inferred From

PTBP1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001018313.1

ENSEMBL

ENSDARG00000019362, ENSDART00000017668, ENSDARP00000011705

ZFIN

ZDB-GENE-050522-492

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